SciCombinator

Discover the most talked about and latest scientific content & concepts.

 

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A large number of studies have proven the efficacy of ayurveda in the field of health and wellness. Panchakola, an ayurvedic formulation, is a general health tonic primarily used to cure fever, inflammation, pain, indigestion, and so on. We investigated effects of panchakola on oxidative stress in MCF-7 breast cancer and human embryonic kidney 293 (HEK293) cells. This work was performed to assess the antineoplastic and free radical-scavenging potential of aqueous extract of panchakola, a polyherbal formulation, in normal and breast cancer cell lines (i.e., HEK and MCF-7, respectively) using MTT assay. Activities of antioxidant enzyme, nitric oxide scavenger, superoxide dismutase, glutathione S-transferase, and glutathione peroxidase were assessed in cell lines incubated with and without panchakola. The outcome was analyzed by spectrophotometer. The results demonstrated increased cytotoxicity in MCF-7 (IC50 16.446 μg/ml) comparable to the results obtained with standard anticancer control (curcumin) with IC50 10.265 μg/ml in MCF-7 cell line. Further, the results obtained from antioxidant assays suggested increased antioxidant activity in MCF-7 cells as compared to normal HEK cells. The results derived from this study suggested panchakola is a strong contender in the field of phytomedicines to fight cancer and free radical-related diseases.

Concepts: Cancer, Breast cancer, Antioxidant, Cell culture, Cell lines, Glutathione, MCF-7, HEK cell

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To histopathologically compare the effect of different orientations of cryopreserved human amniotic membrane (AM) transplant during extraocular muscle surgery in rabbits.

Concepts: Amniotic sac, Amniotic fluid, Extraocular muscles, Amnion

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- The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types.

Concepts: Cancer, Breast cancer, Metastasis, Biopsy, Chemotherapy, Pleural effusion, Mammography

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- Colorectal cancer (CRC) represents the third most-common cancer in developed countries and is a leading cause of cancer deaths worldwide. Two recognized pathways contribute to CRC development: a more-common chromosomal instability pathway and, in 15% of cases, a deficient mismatch repair or microsatellite instability-high (MSI-H) pathway. The MSI-H CRC can be associated with somatic or germline mutations. Microsatellite status has been recognized as a prognostic and predictive biomarker.

Concepts: Cancer, Germline mutation, Oncology, Death, Colorectal cancer, Hereditary nonpolyposis colorectal cancer, Clinical death, Human Development Index

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- As circulating tumor cell (CTC) assays gain clinical relevance, it is essential to address preanalytic variability and to develop standard operating procedures for sample handling in order to successfully implement genomically informed, precision health care.

Concepts: Health care, Clinical trial, Tumor

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Poor collaboration among professional groups may be a major cause of incoherent patient pathways in hospital settings. For over a decade, interprofessional collaboration (IPC) have been stressed as an effective method to enhance the delivery of patient care. This article presents a theory-based stakeholder evaluation of the implementation of an intervention aiming to implement the concept of IPC in a Danish regional hospital from 2012 to 2015. Involving five departments and eight professions, the intervention aimed at developing coherent practices across health professions by optimising patient pathways with the establishment of interprofessional teams as a core element. The evaluation assessed the professionals' views of the intervention. Data were collected through focus group interviews and document analysis. We found that a strengthened focus on patient pathways, well-trained instructors, and an evidence-based strategy for implementation facilitates the success of interventions with a focus on IPC in hospital settings. We furthermore found that cultural and organisational factors are barriers to the implementation of IPC practices, that interruptions of uni-professional work may hamper coordination across professions, and that the interprofessional teams may form new isolated organisational structures.

Concepts: Patient, Focus group, Hospital, Coherence, Physician, Professional, Policy, Implementation

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Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the diagnosis of adrenal metastasis in a high-risk population Objective: While the left adrenal gland is readily accessible via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), data regarding the utility of EUS-FNA in the diagnosis of adrenal lesions remain limited. We aimed to 1) describe the clinical context, adverse event rate, and diagnostic performance of EUS-FNA and 2) compare the safety profile and diagnostic accuracy of EUS-FNA with percutaneous adrenal biopsy.

Concepts: Clinical trial, Biopsy, Diagnosis, Pathology, Medical tests, Needle aspiration biopsy, Glands, Adrenal gland

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Inorganic iodine is often used to treat patients with Graves' thyrotoxicosis who do not tolerate thionamides due to adverse effects. However, predictors of continued inorganic iodine efficacy have not been fully elucidated yet. This study aimed to investigate the factors affecting the continued efficacy of potassium iodide (KI) in patients with Graves' thyrotoxicosis.

Concepts: Effect, Potassium iodide

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Although loco-regional metastases occur in 5-10% of patients with papillary thyroid cancer (PTC), distant metastases are rare, especially to the pancreas. Here we review the literature regarding metastases to the pancreas from PTC and present an illustrative patient.

Concepts: Cancer, Oncology, Lung cancer, Patient, Types of cancer, Thyroid disease, Medullary thyroid cancer, Thyroid neoplasm

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Background Thyroidectomy impairs parathyroid function, even if it does not necessarily lead to postoperative clinical hypocalcaemia. This study is prospective and evaluates the PTH function in non-clinically symptomatic patients after total thyroidectomy performed by two different techniques. Materials and Methods Prospective randomized clinical trial including 269 patients undergoing classic (group A) or harmonic scalpel (group B) total thyroidectomy. Preoperatively and at 48 hours biochemical analysis was performed. Simultaneously a sodium bicarbonate test (SBT) was performed. Results Calcium and PTH were altered for both groups (p <0.001). During SBT at 3 min after infusion, PTH rose and reached its maximum for both groups (p<0.001). Then it decreased at 5 min (p<0.001 and p=0.004) and at 10 min (p=0.006 and p=0.043) and returned to baseline levels. At the 5(th) and 10(th) minute of SBT, some differences were observed between the groups. The difference in clinically obvious parathyroid dysfunction between groups was not significant, but there was a difference in the peak PTH levels after bicarbonate stimulation. Similarly, total secretion during the test, as well as total secretion for the first 10 min was practically the same for the two groups. Additionally, partial subclinical post-operative hypoparathyroidism was clearly more common in the HSST group (p<0.001) Conclusion SBT demonstrated more impairment in the harmonic scalpel group, parathyroid function was altered after thyroidectomy.

Concepts: Clinical trial, Surgery, Parathyroid hormone, Parathyroid gland, Hypoparathyroidism, Thyroidectomy, Hyperparathyroidism, Sodium bicarbonate