SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: The Korean journal of internal medicine

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Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a rat model of chronic tacrolimus (TAC) nephropathy.

Concepts: Tang Dynasty, Ming Dynasty, Chinese character, Traditional Chinese medicine, Herbalism, Alternative medicine, Traditional Chinese characters, Chinese herbology

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Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals, and has recently emerged in the community. The impact of methicillin-resistance on mortality and medical costs for patients with S. aureus bacteremia (SAB) requires reevaluation.

Concepts: Pneumonia, Methicillin-resistant Staphylococcus aureus, Staphylococcus aureus

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Fecal calprotectin (FC) is known to correlate with disease activity and can be used as a predictor for relapse or treatment response in inflammatory bowel disease (IBD). We evaluated the usefulness of FC as a biomarker for disease activity in patients with IBD using both enzyme-linked immunosorbent assay (ELISA) and a quantitative point-of-care test (QPOCT).

Concepts: Multiplex, Inflammatory bowel disease, Immunoassay, Assay, ELISPOT, ELISA

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To investigate the efficacy and safety of tocilizumab (TCZ) humanized anti-interleukin-6 receptor monoclonal antibody, in Korean patients with active rheumatoid arthritis (RA) refractory to conventional disease modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX).

Concepts: Hydroxychloroquine, Disease-modifying antirheumatic drug, Immunology, Psoriatic arthritis, Rheumatology, Methotrexate, Monoclonal antibodies, Rheumatoid arthritis

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The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) or European Organization for Research and Treatment of Cancer (EORTC) criteria are used to assess metabolic tumor responses. However, tumor responses have shown considerable discrepancies between the morphologic criteria (Response Evaluation Criteria in Solid Tumors [RECIST]) and metabolic criteria. We performed this pooled study to compare the RECIST and metabolic criteria in the assessment of tumor responses.

Concepts: Neoplasm, Educational evaluation, Tumor, Evaluation, Cancer, Positron emission tomography, Assessment, Oncology

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The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical studies of asthma therapies routinely use the change of airway responsiveness as an objective outcome. The aim of this study was to assess the relationship between serial MBPT and clinical profiles in patients with asthma.

Concepts: Bronchodilator, Cultural studies, Test method, Clinical trial, Evaluation methods, Psychometrics, Asthma

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E-health technologies have been implemented for the management of Crohn’s disease (CD). We aimed to identify differences between patient activities at home and at routine clinic visits using a web-based self-reporting CD symptom diary (CDSD) and to determine the impact of this disparity on clinical outcomes.

Concepts: Compact Disc, Types of healthcare facilities, Activity, Crohn's disease, Gastroenterology, Clinic, Hospital

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Pyomyositis is an infective condition with primary involvement of the skeletal muscles. There is sparse recent literature on patients with pyomyositis.

Concepts: United Kingdom, India

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Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE and is the most critical predictor of morbidity and mortality. The immunopathogenesis of SLE is complex and most clinical trials of biologics targeting immune cells or their mediators have failed to show efficacy in SLE patients. It has therefore become increasingly clear that additional, local factors give rise to the inflammation and organ damage. In this review, we describe recent advances in the role of renal resident cells, including podocytes, mesangial cells, and epithelial cells, in the pathogenesis of lupus nephritis.

Concepts: Cyclophosphamide, Rheumatology, Lupus nephritis, Lupus erythematosus, Rheumatoid arthritis, Glomerulonephritis, Immune system, Systemic lupus erythematosus

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Data on dexamethasone, cytarabine, and cisplatin (DHAP) as a mobilization regimen, compared to high-dose cyclophosphamide (HDC), for up-front autologous stem cell transplantation (ASCT) in non-Hodgkin’s lymphoma (NHL) is limited.

Concepts: Antineoplastic drugs, Organ transplant, Chemotherapy