SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: The Korean journal of internal medicine

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Inhibition of tumor necrosis factor (TNF) is an effective treatment for rheumatoid arthritis (RA), but safety concerns about malignancy remain. The aim of this study was to evaluate cancer risk in RA patients treated with TNF inhibitors (TNFi), based on Korean Nationwide Health Insurance claims data.

Concepts: Inflammation, Health economics, Healthcare reform, Cancer, Oncology, Rheumatoid arthritis, Rheumatology, Tumor necrosis factor-alpha

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Few studies have addressed whether there are differences in clinical efficacy between intravenous methylprednisolone (methyl-Pd) and intravenous immunoglobulin (IVIg) use.

Concepts: Immune system, Antibody, Glycoproteins, Humoral immunity, Immunity, Intravenous immunoglobulin, X-linked agammaglobulinemia, Idiopathic thrombocytopenic purpura

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We evaluated the effects of a multifaceted intervention for controlling a carbapenem-resistant Acinetobacter baumannii (CRAB) epidemic in an intensive care unit (ICU) with no restrictions on carbapenem use.

Concepts: Pseudomonadales, Acinetobacter baumannii, Acinetobacter

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Olmesartan, a widely used angiotensin II receptor blocker (ARB), has been linked to sprue-like enteropathy. No cases of olmesartan-associated enteropathy have been reported in Northeast Asia. We investigated the associations between olmesartan and other ARBs and the incidence of enteropathy in Korea.

Concepts: Cohort study, Endocrinology, Angiotensin, Renin-angiotensin system, Angiotensin II receptor antagonist, East Asia, South Korea, Angiotensin receptor

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To evaluate and select microRNAs relevant to acute myeloid leukemia (AML) pathogenesis, we analyzed differential microRNA expression by quantitative small RNA next-generation sequencing using duplicate marrow samples from individual AML patients.

Concepts: Gene, RNA, Acute myeloid leukemia

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The purpose of the study is to investigate the associations between sarcopenia and health-related quality of life in elderly men and women in Korea.

Concepts: Death, Geriatrics, Personal life

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Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC).

Concepts: Medicine, Epidemiology, Cancer, Oncology, Evolution, Histology, Colorectal cancer

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Fibromyalgia (FM) is a common rheumatologic disease characterized by chronic widespread pain, along with various clinical manifestations including atypical autoimmune characteristics. Despite its high prevalence, there remain no approved laboratory tests to identify specific manifestations of FM, or to rule out FM from other rheumatic diseases. Anti-dense fine speckled 70 (anti-DFS70) antibodies were initially identified as a form of anti-nuclear antibodies in a patient with interstitial cystitis. Anti-DFS70 antibodies are found in ≤ 10% of healthy individuals, but have suggestive negative association with autoimmune diseases; however, the clinical significance of these autoantibodies in FM patients remains poorly understood.

Concepts: Immune system, Medicine, Epidemiology, Disease, Medical terms, Rheumatoid arthritis, Rheumatology, Autoimmune diseases

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Magnetic resonance imaging (MRI) is a sensitive and useful method for the detection of synovitis and joint destruction in rheumatoid arthritis (RA) patients. However, the patterns of MRI-detected bone erosion, bone marrow edema (BME), synovitis, and tenosynovitis have received insufficient attention. Therefore, this study evaluated the patterns of bone erosion, BME, synovitis, and tenosynovitis, and calculated the RA-MRI score (RAMRIS) of patients with RA at the carpal and metacarpophalangeal (MCP) joints using MRI.

Concepts: Bone, Bone marrow, Rheumatoid arthritis, Nuclear magnetic resonance, Osteoarthritis, Magnetic resonance imaging, Wrist, Synovitis

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Elderly patients (≥ 80 years) with colorectal cancer (CRC) tend to avoid active treatment at the time of diagnosis despite of recent advances in treatment. The aim of this study was to determine treatment propensity of elderly patients aged ≥ 80 years with CRC in clinical practice and the impact of anticancer treatment on overall survival (OS).

Concepts: Clinical trial, Cancer, Death, Colorectal cancer, Gerontology, Ageing