Discover the most talked about and latest scientific content & concepts.

Journal: The journal of allergy and clinical immunology. In practice


Peanut oral immunotherapy, using a variety of approaches, has been previously shown to induce desensitization in peanut-allergic subjects, but no products have been approved for clinical use by regulatory agencies.

Concepts: Clinical trial, Randomized controlled trial, Effectiveness,, Allergy, Placebo


The COVID-19 pandemic caused dramatic changes in daily routines and healthcare utilization and delivery patterns in the United States. Understanding the influence of these changes and associated public health interventions on asthma care is important to determine effects on patient outcomes and identify measures that will ensure optimal future healthcare delivery.


Bronchial asthma has not been adequately assessed in the coronavirus disease 2019 (COVID-19). Respiratory allergy is associated with significant reductions in ACE2 receptors expression, which is the entry receptor for COVID-19.


The recent Food and Drug Administration (FDA) approval of two highly effective COVID-19 vaccines from Pfizer-BioNtech and Moderna has brought hope to millions of American in the midst of an ongoing global pandemic. The FDA Emergency Use Authorization guidance for both vaccines is to not administer the vaccine to individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of the COVID-19 vaccine. The Centers for Diseases Control and Prevention (CDC) advises that all patients should be observed for 15 minutes after COVID-19 vaccination and staff must be able to identify and manage anaphylaxis. Post-FDA approval, despite very strong safety signals in both phase 3 trials, reports of possible allergic reactions have raised public concern. To provide reassurance and support during widespread vaccination across America, allergists must offer clear guidance to patients based on the best information available, but also in accordance with the broader recommendations of our US regulatory agencies. This review summarizes vaccine allergy epidemiology and proposes risk stratification schema: (1) for individuals with different allergy histories to safely receive their first COVID-19 vaccine and (2) for individuals who develop a reaction to their first dose of COVID-19 vaccine.


Underuse of controller medicines among children with asthma remains widespread despite national guidelines.

Concepts: Pharmacology, Corticosteroid, Pharmaceutical drug


There is a paucity of data that describe the clinical course of hereditary angioedema (HAE) in children.

Concepts: Angioedema, Hereditary angioedema


Anaphylaxis is a potentially life-threatening systemic allergic reaction. Studies suggest that the incidence of anaphylaxis is increasing; however, recent trends in emergency department (ED) visits for anaphylaxis in the United States have not been studied.

Concepts: Asthma, United States, Allergy


Allergen immunotherapy is the only disease-modifying treatment for allergic diseases. Sublingual immunotherapy (SLIT) in liquid and tablet form has been used by clinicians in Europe for years, but has only recently gained popularity and approval in the United States. In 2014, the US Food and Drug Administration approved 3 SLIT tablets for the treatment of allergic rhinitis, with or without allergic conjunctivitis. Immunotherapy treatment strategies for the polysensitized patient vary between the United States and Europe. This variation hinges upon whether the polysensitized patient is truly polyallergic. Polysensitization is the positive response to 2 or more allergens on skin prick testing or in vitro specific-IgE testing. Polyallergy is the symptomatic clinical response to 2 or more allergens. In this review, we discuss the use of SLIT in the United States with a focus on treating the polyallergic patient with SLIT.

Concepts: Asthma, United States, Immunology, Allergy, Allergology, Allergen immunotherapy, Tablet PC, Allergic conjunctivitis


Recurrent sinopulmonary infections are common in children with CHARGE (Coloboma, Heart disease, choanal Atresia, growth/mental Retardation, Genitourinary malformations, Ear abnormalities) syndrome, but no prospective studies on immune function have been conducted.

Concepts: Immune system, Infectious disease, Infection, Coloboma, Choanal atresia, CHARGE syndrome


The high levels of eicosanoid production and the clinical efficacy of leukotriene-modifying pharmacotherapies for patients with aspirin-exacerbated respiratory disease (AERD) suggest that other interventions targeting arachidonic acid dysregulation may also improve disease control.

Concepts: Fatty acid, Fatty acids, Essential fatty acid, Omega-6 fatty acid, Eicosanoid, Prostaglandin, Linoleic acid, Arachidonic acid