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Journal: Pain practice : the official journal of World Institute of Pain


Chronic non-malignant pain perceived in the pelvic region commonly presents as a diagnostic challenge and is often difficult to manage. Treatment options are delayed as well as limited. The prevalence in the United States and the United Kingdom has been estimated to range from 14.7 % to 24% respectively (1, 2). Common chronic pelvic pain syndromes include interstitial cystitis, chronic prostatitis, coccygodynia, vulvodynia, chronic proctalgia, and pudendal neuralgia. This article is protected by copyright. All rights reserved.

Concepts: United States, United Kingdom, Pain, English language, Radio, Interstitial cystitis, Copyright, Chronic pain syndromes


Results from a phase-3, prospective, randomized, double-blind, placebo-controlled trial evaluating sufentanil sublingual tablet 30 mcg (SST) for the management of pain after ambulatory abdominal surgery are presented.

Concepts: Opioid


Several studies have documented increased cardiovascular risk factors, particularly hypercholesterolemia, in the migraine population with respect to controls. However, no studies have investigated the possible relationship between headache severity parameters and lipid serum levels.

Concepts: Cholesterol, Myocardial infarction, Atherosclerosis, Cardiovascular disease, Intracranial pressure, Paracetamol


Impaired pain inhibitory and enhanced pain facilitatory mechanisms are repeatedly reported in patients with central sensitization pain. However, the exact effects of frequently prescribed opioids on central pain modulation are still unknown.

Concepts: Rheumatoid arthritis, Rheumatology, Opioid, Pain, Morphine, Heroin, Naloxone, Arthritis


Pain is still a burden for many patients with cancer. A recent trial showed superiority of methadone over fentanyl in neuropathic pain, and we expect that this could increase the amount of patients treated with methadone.

Concepts: Head and neck anatomy, Head and neck, Pain, Head and neck cancer, Fentanyl


Temporomandibular disorder (TMD) is a very wide term which includes a variety of clinical issues related to the masticatory muscles, the temporomandibular joint (TMJ), and their associated structures (1) . For TMD patients the main concern is pain, and it is the most common reason for medical consultation; but pain makes also a great challenge for clinicians (2) . In fact, dysfunction of the central nervous system when processing nociceptive input has been stated as a factor involved in the onset and maintenance of pain in patients with chronic TMD (3) This article is protected by copyright. All rights reserved.

Concepts: Central nervous system, Nervous system, Medicine, Brain, Skull, Joint, Temporomandibular joint, Temporomandibular joint disorder


To examine medication adherence and healthcare costs for combination prescription initiators (duloxetine/milnacipran/venlafaxine with pregabalin) versus monotherapy initiators (duloxetine, milnacipran, venlafaxine, and pregabalin) among patients with fibromyalgia syndrome (FMS).

Concepts: Pharmacology, Prescription drug, Syndromes, Fibromyalgia, Generalized anxiety disorder, Pregabalin, Gabapentin, Duloxetine


Patient satisfaction is used to measure physician performance in hospital and governmental practice settings. There is limited understanding about factors affecting satisfaction in a chronic pain management setting for patients prescribed chronic opioids.

Concepts: Patient, Hospital, Physician, Doctor-patient relationship, Pain, Setting, Chronic pain


Lumbopelvic stabilization training (LPST) may provide therapeutic benefits on pain modulation in chronic nonspecific low back pain conditions. This study aimed to examine the effects of LPST on pain threshold and pain intensity in comparison to the passive automated cycling intervention and control intervention among patients with chronic nonspecific low back pain.

Concepts: Low back pain, Back pain


Chronic postsurgical pain (CPSP) is a debilitating and costly condition. Risk factors for CPSP after autologous breast reconstruction have not been clearly established. Previously, we demonstrated that transversus abdominis plane (TAP) catheters delivering intermittent local anesthetic reduced postoperative morphine consumption. This prospective follow-up study aims to (1) compare the incidence of CPSP after autologous breast reconstruction between patients who received postoperative intermittent TAP catheters with bupivacaine or saline boluses and (2) assess the factors that contribute to the development and maintenance of CPSP in this study cohort.

Concepts: Cohort study, Epidemiology, Anesthesia, Transversus abdominis muscle, Epidural, Local anesthetic, Breast reconstruction, Anesthetic