SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: Ophthalmology

437

Myopia is a common cause of vision loss, with uncorrected myopia the leading cause of distance vision impairment globally. Individual studies show variations in the prevalence of myopia and high myopia between regions and ethnic groups, and there continues to be uncertainty regarding increasing prevalence of myopia.

Concepts: Ophthalmology, Myopia, Visual impairment, Anarchism

271

To determine the heritability of nuclear cataract progression and to explore prospectively the effect of dietary micronutrients on the progression of nuclear cataract.

Concepts: Genetics, Nutrition, Cataract

169

Improving adherence to manage elevated intraocular pressure (IOP) remains an unmet need. A topical bimatoprost ocular insert was compared with twice-daily timolol eye drops in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) treated for 6 months.

Concepts: Randomized controlled trial, Intraocular pressure, Glaucoma, Ophthalmology, Trabecular meshwork, Ocular hypertension, Dorzolamide

162

To analyze the effect of baseline presence and height of pigment epithelial detachments (PEDs) on visual and anatomic outcomes at 24 months in patients with neovascular age-related macular degeneration (AMD) treated with ranibizumab.

Concepts: Melanin, Macular degeneration, Ranibizumab

157

To provide an initial assessment of the safety of a recombinant adeno-associated virus vector expressing RPE65 (rAAV2-CB-hRPE65) in adults and children with retinal degeneration caused by RPE65 mutations.

Concepts: DNA, Ophthalmology, Adeno-associated virus, Gene therapy, Blindness, Leber's congenital amaurosis, Amaurosis, RPE65

141

Lifitegrast is an integrin antagonist that decreases T-cell-mediated inflammation associated with dry eye disease (DED). We report the results of OPUS-2, a phase III study evaluating the efficacy and safety of lifitegrast compared with placebo for the treatment of DED.

Concepts: Rheumatoid arthritis, Eye, Ophthalmology, Keratoconjunctivitis sicca, Eye disease

57

Acquired nystagmus, a highly symptomatic consequence of damage to the substrates of oculomotor control, often is resistant to pharmacotherapy. Although heterogeneous in its neural cause, its expression is unified at the effector-the eye muscles themselves-where physical damping of the oscillation offers an alternative approach. Because direct surgical fixation would immobilize the globe, action at a distance is required to damp the oscillation at the point of fixation, allowing unhindered gaze shifts at other times. Implementing this idea magnetically, herein we describe the successful implantation of a novel magnetic oculomotor prosthesis in a patient.

Concepts: Eye, Amputation, Harmonic oscillator, Pupil, Simple harmonic motion

51

The Argus II Retinal Prosthesis System (Second Sight Medical Products, Inc, Sylmar, CA) was developed to restore some vision to patients blind as a result of retinitis pigmentosa (RP) or outer retinal degeneration. A clinical trial was initiated in 2006 to study the long-term safety and efficacy of the Argus II System in patients with bare or no light perception resulting from end-stage RP.

Concepts: Health care, Medicine, Avicenna, Physician, Retina, Ophthalmology, Retinitis pigmentosa, Blindness

45

42

To describe the ocular findings of 3 cases of suspected congenital Zika viral infection with microcephaly and maculopathy.

Concepts: Infection