Discover the most talked about and latest scientific content & concepts.

Journal: Minerva cardioangiologica


The effects of beta–blockers in pediatric and congenital heart disease (CHD) patients suffering from heart failure are controversial. We performed a meta–analysis to determine whether beta–blockers are effective for heart failure in pediatric and CHD patients.

Concepts: Medicine, Myocardial infarction, Hypertension, Cardiology, Heart failure


Transradial access has nowadays become a standard of care for percutaneous coronary angiography and intervention. This approach has demonstrated significant reduction in bleeding rate, length of hospital stay, and improvement in clinical outcomes when compared to the traditional transfemoral approach. Due to its advantages this new access is also increasingly being used in non-coronary visceral or peripheral interventions. However, this novel approach may lead to severe catheter kinking and twisting and further manipulation may be required to unravel the catheter and avoid complication. Purpose of this technical review is to present the current techniques and trends in preventing and resolving issues related to radial access catheter kinks.

Concepts: Present, Time, Atherosclerosis, Cardiology, Atheroma, Angiography, Intervention, The Current


Palliative care is an alternate therapeutic approach that involves specialized medical care of a patient diagnosed with serious life threatening illness like heart failure. The prime aim of the palliative care is to provide patient with relief from the symptoms, pain, physical stress, and mental stress of the diagnosed disease. The palliative care helps in improving the quality of life for both the patient and the family. Advanced heart failure (HF) is a disease process that carries a high burden of symptoms, suffering, and death. Palliative care can complement traditional care to improve symptom amelioration, patient–caregiver communication, emotional support, and medical decision making. The present review summarized all the available on alternative palliative approaches provided to heart patient by a team of physicians , nurses and other healthcare professionals.

Concepts: Health care, Medicine, Disease, Medical terms, Patient, Illness, Symptomatic treatment, Suffering


The efficacy of RADPAD ® (a sterile, lead–free drape) has been demonstrated to reduce the scatter radiation to the primary operator during fluoroscopic procedures. However, the use of the RADPAD ® during TAVI procedures has not been studied. Transcatheter Aortic Valve Implantation (TAVI) is now an established treatment for patients with symptomatic severe aortic stenosis who are deemed inoperable or at high risk for conventional surgical aortic valve replacement (AVR). Consequently the radiation exposure to the patient and the interventional team from this procedure has become a matter of interest and importance. Methods to reduce radiation exposure to the interventional team during this procedure should be actively investigated.

Concepts: Radiology, Aortic valve stenosis


Chronic increase in left ventricular filling pressure represents one of the most important mechanism underlying the structural, as well as the electrical, atrial chamber remodeling leading to atrial fibrillation. The present pilot pathophysiological study sought to investigate possible relationship between short–period cross–spectral coherence of P–Q, R–R and P–P intervals and echocardiographic indices of left ventricular and atrial function.

Concepts: Blood, Cardiology, Ejection fraction, Heart, Atrial fibrillation, Ventricle, Semitone, Jugular venous pressure


Rivaroxaban is the first novel oral anticoagulant to receive regulatory approval for non-valvular atrial fibrillation (NVAF) patients who require cardioversion. The MonaldiVert real life experience showed positive benefit-risk profile of short term rivaroxaban administration for transesophageal echocardiogram guided cardioversion in patients who had not achieved adequate pre-procedural vitamin k antagonist (VKA) anticoagulation.

Concepts: Atrial fibrillation, Warfarin, Economics, Anticoagulant, Heparin, Dabigatran, Anticoagulants, Vitamin K


Chronic kidney disease (CKD) is associated with increased risk of mortality. We examined the impact of moderate and severe CKD at presentation on short- and long-term mortality among unselected patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI).

Concepts: Chronic kidney disease, Myocardial infarction, Atherosclerosis, Medical terms, Cardiology, Heart failure, Percutaneous coronary intervention, Atheroma


Despite the availability of anti-hypertensive medications with proven efficacy and good tolerability, many hypertensive patients have blood pressure levels(BP) not at the goals set by international societies. Some of these patients are either non-adherent to the prescribed drugs or not optimally treated. However, a proportion, despite adequate treatment, has resistant hypertension(RH) defined as office BP above goal despite the use of ≥3 antihypertensive medications at maximally tolerated doses (one ideally being a diuretic). Diagnosis of RH based upon office measurements, however, needs confirmation through 24-h BP monitoring to exclude “white coat” RH since cardiovascular events and mortality rates follow mean ambulatory BPs. Although several studies have approached the issue of the prevalence of RH in the hypertensive population, its prevalence is by and large based upon reasonable but approximate estimates for reasons detailed in the text. Standardized combination therapy based upon angiotensin converting enzyme inhibitors or angiotensin receptor blockers, amlodipine or other dihydropiridine calcium channel blockers and a diuretic (thiazide and thiazide-like compounds as cholrthalidone or indapamide) has been advocated to treat RH with spironolactone as fourth add-on drug. Interventional procedures such as renal denervation have been devised to treat RH and implemented in some patients with RH not responding to medical treatment. However, the results of this interventional procedure have insofar not been positive. It is unclear whether RH constitutes a specific phenotype of EH or should rather be considered a more serious form of uncontrolled hypertension. Whatever the case, its presence associates with and increased cardio- and cerebrovascular risk and deserves, therefore, particular care.

Concepts: Hypertension, Blood pressure, Angiotensin, Renin-angiotensin system, Angiotensin II receptor antagonist, Diuretic, Thiazide, Calcium channel blocker


Because of the impressive increase in the risk of cardiovascular complications associated with levels of BP previously considered to be normal, the JNC 7 report has introduced a new classification that includes the term “prehypertension” for those with BPs ranging from 120-139 mmHg systolic and/or 80-89 mmHg diastolic. In the framework of a salt reduction as recommended by health authorities, this trial evaluates if the use of Symbiosal® reduces more prehypertension than standard table marine salt (NaCl).

Concepts: Epidemiology, Clinical trial, Blood, Hypertension, Blood pressure, Ventricle, Orthostatic hypotension, Prehypertension


Cardiac Resynchronization Therapies (CRTs) have been demonstrated to improve the clinical management and prognosis of selected patients with heart failure.

Concepts: Medicine, Cardiology, Heart, Avicenna, Heart disease, Cardiac tamponade, Sinoatrial node