SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: Journal of the American College of Cardiology

118

Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D. Low vitamin D levels are associated with a worse prognosis.

Concepts: Vitamin D, Blood, Cardiology, Heart, Ventricle, Mitral valve, Left ventricle, Beriberi

104

The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world.

99

People who are physically active have at least a 30% lower risk of death during follow-up compared with those who are inactive. However, the ideal dose of exercise for improving longevity is uncertain.

Concepts: Physics, Demography, Risk, Muscle, Physical exercise, Exercise, Uncertainty, Copenhagen

87

Although running is a popular leisure-time physical activity, little is known about the long-term effects of running on mortality. The dose-response relations between running, as well as the change in running behaviors over time, and mortality remain uncertain.

84

GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non-vitamin K antagonist oral anticoagulant (NOAC), became available.

Concepts: Heart, Stroke, Atrial fibrillation, Warfarin, Atrial flutter, Anticoagulant, Dabigatran

83

The potential cardiovascular benefits of several trending foods and dietary patterns are still incompletely understood, and nutritional science continues to evolve. However, in the meantime, a number of controversial dietary patterns, foods, and nutrients have received significant media exposure and are mired by hype. This review addresses some of the more popular foods and dietary patterns that are promoted for cardiovascular health to provide clinicians with accurate information for patient discussions in the clinical setting.

Concepts: Health, Nutrition

73

The diagnosis of heart failure may be challenging because symptoms are rather nonspecific. Elevated left ventricular (LV) filling pressure may be used to confirm the diagnosis, but cardiac catheterization is often not practical. Echocardiographic indexes are therefore used as markers of filling pressure.

Concepts: Blood, Cardiology, Heart, Right ventricle, Ventricle, Aorta, Mitral valve, Left ventricle

64

QT interval-prolonging drug-drug interactions (QT-DDIs) may increase the risk of life-threatening arrhythmia. Despite guidelines for testing from regulatory agencies, these interactions are usually discovered after drugs are marketed and may go undiscovered for years.

Concepts: Pharmacology, Drug, Cardiac electrophysiology, Drugs, Experiment

61

Cardiac troponin is an independent predictor of cardiovascular mortality in individuals without symptoms or signs of cardiovascular disease. The mechanisms for this association are uncertain, and a role for troponin testing in the prevention of coronary heart disease has yet to be established.

Concepts: Disease, Blood, Heart, Blood vessel, Risk, Cardiac muscle, Heart disease, Circulatory system

58

Proprotein convertase subtilisin/kexin type 9 monoclonal antibodies can reduce low-density lipoprotein cholesterol (LDL-C) to very low levels when added to background lipid-lowering therapy.

Concepts: Cholesterol, Atherosclerosis, Cardiovascular disease, Low-density lipoprotein, Atheroma, Niacin, Lipoprotein