SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: Journal of the American College of Cardiology

163

Left atrial appendage closure (LAAC) using the Watchman device was FDA-approved as a stroke prevention alternative to warfarin for patients with non-valvular atrial fibrillation. However, clinical decision-making is confounded by the fact that while LAAC avoids the anticoagulant-related lifetime risk of bleeding, implantation is associated with up-front complications. Thus, enthusiasm for LAAC as a treatment option has been appropriately tempered, particularly as the therapy is introduced beyond the clinical trial sites into general clinical practice.

Concepts: Clinical trial, Stroke, Atrial fibrillation, Warfarin, Atrial flutter, Clinical trial protocol, Left atrial appendage occlusion, Left atrial appendage

161

Ischemic heart disease is a complex disease process caused by the development of coronary atherosclerosis, with downstream effects on the left ventricular myocardium. It is characterized by a long preclinical phase, abrupt development of myocardial infarction, and more chronic disease states such as stable angina and ischemic cardiomyopathy. Recent advances in computed tomography (CT) and cardiac magnetic resonance (CMR) now allow detailed imaging of each of these different phases of the disease, potentially allowing ischemic heart disease to be tracked during a patient’s lifetime. In particular, CT has emerged as the noninvasive modality of choice for imaging the coronary arteries, whereas CMR offers detailed assessments of myocardial perfusion, viability, and function. The clinical utility of these techniques is increasingly being supported by robust randomized controlled trial data, although the widespread adoption of cardiac CT and CMR will require further evidence of clinical efficacy and cost effectiveness.

Concepts: Myocardial infarction, Atherosclerosis, Angina pectoris, Cardiology, Heart, Atheroma, Artery, Coronary circulation

155

Patients with heart failure (HF) are at high risk for hospital readmission in the first 30 days following HF hospitalization.

Concepts: Patient, Hospital, Cardiology, Physician

148

The optimal duration of dual antiplatelet therapy (DAPT) after implantation of newer-generation drug-eluting stents (DES) remains uncertain. Similarly, questions remain about the role of DAPT in long-term therapy of stable post-myocardial infarction (MI) patients.

Concepts: Medicine

136

There is no nonparenteral medication for the rapid termination of paroxysmal supraventricular tachycardia.

121

Absence of cardiovascular risk factors (CVRFs) is traditionally considered low risk for atherosclerosis; however, individuals without CVRFs, as currently defined, still have events.

Concepts: Myocardial infarction, Atherosclerosis, Blood vessel, Cardiovascular disease, Low-density lipoprotein, In the Absence of Truth

121

The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world.

116

Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D. Low vitamin D levels are associated with a worse prognosis.

Concepts: Vitamin D, Blood, Cardiology, Heart, Ventricle, Mitral valve, Left ventricle, Beriberi

104

People who are physically active have at least a 30% lower risk of death during follow-up compared with those who are inactive. However, the ideal dose of exercise for improving longevity is uncertain.

Concepts: Physics, Demography, Risk, Muscle, Physical exercise, Exercise, Uncertainty, Copenhagen

96

The ideal cardiovascular health score (ICHS) is recommended for use in primary prevention. Simpler tools not requiring laboratory tests, such as the Fuster-BEWAT (blood pressure [B], exercise [E], weight [W], alimentation [A], and tobacco [T]) score (FBS), are also available.

Concepts: Public health, Blood, Blood vessel, Cardiovascular disease, Artery, Experiment, Prevention, Primary ideal