Discover the most talked about and latest scientific content & concepts.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology


Patients with cancer are more likely to file for bankruptcy than the general population, but the impact of severe financial distress on health outcomes among patients with cancer is not known.

Concepts: Epidemiology, Risk, Actuarial science, Default, Insolvency Act 1986, Bankruptcy, Insolvency, Insolvency law



The objective of this study was to determine whether the 21-gene Recurrence Score (RS) provides clinically meaningful information in patients with de novo stage IV breast cancer enrolled in the Translational Breast Cancer Research Consortium (TBCRC) 013.

Concepts: Cancer, Breast cancer, Metastasis, Cancer staging, Pleural effusion, Cancer support group, Janet Lane-Claypon, National Breast Cancer Coalition


To test the association of androgen deprivation therapy (ADT) in the treatment of prostate cancer with subsequent Alzheimer’s disease risk.

Concepts: Cancer, Metastasis, Estrogen, Prostate cancer, Radiation therapy, Testosterone, Screening, Androgen


Accurate illness understanding enables patients to make informed decisions. Evidence of the influence of prognostic discussions on the accuracy of illness understanding by patients would demonstrate the value of discussions.

Concepts: Critical thinking, Medical terms, Accuracy and precision


American Society of Clinical Oncology (ASCO), the leading medical professional oncology society, is committed to lessening the burden of cancer and as such will promote underused interventions that have the potential to save millions of lives through cancer prevention. As the main providers of cancer care worldwide, our patients, their families, and our communities look to us for guidance regarding all things cancer related, including cancer prevention. Through this statement and accompanying recommendations, ASCO hopes to increase awareness of the tremendous global impact of human papillomavirus (HPV) -caused cancers, refocus the discussion of HPV vaccination on its likely ability to prevent millions of cancer deaths, and increase HPV vaccination uptake via greater involvement of oncology professionals in ensuring accurate public discourse about HPV vaccination and calling for the implementation of concrete strategies to address barriers to vaccine access and acceptance.

Concepts: Immune system, Medicine, Cancer, Oncology, Human papillomavirus, HPV vaccine, Anal cancer


The WHO guidelines on cancer pain management recommend a sequential three-step analgesic ladder. However, conclusive data are lacking as to whether moderate pain should be treated with either step II weak opioids or low-dose step III strong opioids.

Concepts: Opioid, Pain, Morphine, Heroin, Buprenorphine, Hydrocodone, Methadone, Codeine



Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates.

Concepts: Vitamin D, Cancer, Metastasis, Oncology, Hereditary nonpolyposis colorectal cancer, United Kingdom, BRCA2, Welsh language


SIRFLOX was a randomized, multicenter trial designed to assess the efficacy and safety of adding selective internal radiation therapy (SIRT) using yttrium-90 resin microspheres to standard fluorouracil, leucovorin, and oxaliplatin (FOLFOX)-based chemotherapy in patients with previously untreated metastatic colorectal cancer.

Concepts: Cancer, Breast cancer, Chemotherapy, Prostate cancer, Radiation therapy, Colorectal cancer, Melanoma, Selective internal radiation therapy