Discover the most talked about and latest scientific content & concepts.

Journal: Journal of affective disorders


Several studies have supported the antidepressant effects of curcumin (from the spice turmeric) and saffron for people with major depressive disorder. However, these studies have been hampered by poor designs, small sample sizes, short treatment duration, and similar intervention dosages. Furthermore, the antidepressant effects of combined curcumin and saffron administration are unknown.

Concepts: Selective serotonin reuptake inhibitor, Bipolar disorder, Major depressive disorder, Dysthymia, Sertraline


Various psychological interventions are effective for reducing symptoms of anxiety when used alone, or as an adjunct to anti-anxiety medications. Recent studies have further indicated that smartphone-supported psychological interventions may also reduce anxiety, although the role of mobile devices in the treatment and management of anxiety disorders has yet to be established.

Concepts: Anxiety, Psychology, Epidemiology, Randomized controlled trial, Mental disorder, Anxiety disorder, Anxiolytic


In the past decade, a large body of research has demonstrated that internet-based interventions can have beneficial effects on depression. However, only a few clinical trials have compared internet-based depression therapy with an equivalent face-to-face treatment. The primary aim of this study was to compare treatment outcomes of an internet-based intervention with a face-to-face intervention for depression in a randomized non-inferiority trial.

Concepts: Clinical trial, Effectiveness,, The Trial, Clinical psychology, Cognitive behavioral therapy, Intervention


There have been conflicting findings on temporal variation in suicide risk and few have examined the phenomenon in clinical populations. The study investigated seasonal and other temporal patterns using national data.

Concepts: Population, Sociology


Vegetarian diets are associate with cardiovascular and other health benefits, but little is known about mental health benefits or risks.

Concepts: Health economics, Health insurance


We examined whether seasonal variations in depressive symptoms occurred independently of demographic and lifestyle factors, and were related to change in day length and/or outdoor temperature.

Concepts: Epidemiology, Cross-sectional study, United Kingdom, Anarchy in the U.K., Biobank, UK Biobank


Fatigue is not only a core symptom of major depressive disorder (MDD), but also a common residual symptom. We determined the sociodemographic, clinical, and pharmacologic factors that were associated with fatigue in patients with remission or partial remission of MDD.

Concepts: Pharmacology, Cognitive behavioral therapy, Major depressive disorder, Dysthymia, Depression


Depression and alcohol misuse are among the most prevalent diagnoses in suicide fatalities. The risk posed by these disorders is exacerbated when they co-occur. Limited research has evaluated the effectiveness of common depression and alcohol treatments for the reduction of suicide vulnerability in individuals experiencing comorbidity.

Concepts: Effect, Alcoholism, Mental disorder, Schizophrenia, Bipolar disorder, Major depressive disorder, Suicide


BACKGROUND: The burden of rising health care expenditures has created a demand for information regarding the clinical and economic outcomes associated with Complementary and Alternative Medicines. Clinical controlled trials have found St. John’s wort to be as effective as antidepressants in the treatment of mild to moderate depression. The objective of this study was to develop a model to assess the cost-effectiveness of St. John’s wort based on this evidence. METHODS: A Markov model was constructed to estimate health and economic impacts of St. John’s wort versus antidepressants. Outcomes were treatment costs, quality-adjusted life years (QALYs) and Net Monetary Benefits (NMB). Probabilistic analyses were conducted on key model parameters. RESULTS: The average NMB across 5000 simulations identified St. John’s wort as the strategy with the highest net benefit. The total cost savings for SJW were $359.66 and $202.56 per individual for venlafaxine and sertraline respectively, with a gain of 0.08 to 0.12 QALYs over the 72 weeks of the model. LIMITATIONS: A lack of direct comparative clinical trial data comparing SJW to venlafaxine and limited data with sertraline as a comparator was a major limitation. CONCLUSIONS: In this model, St. John’s wort was shown to be a cost-effective alternative to generic antidepressants. Patients are more likely to receive treatment for a duration consistent with professional guidelines for treatment of major depression due to reduced incidence of adverse effects, improving outcomes. This represents an important option in the treatment of Major Depressive Disorder.

Concepts: Clinical trial, Selective serotonin reuptake inhibitor, Major depressive disorder, Bupropion, Sertraline, Fluoxetine, Venlafaxine, St John's wort


Bipolar disorder (BD) is a highly incapacitating disease typically associated with high rates of familial dysfunction. Despite recent literature suggesting that maternal care is an important environmental factor in the development of behavioral disorders, it is unclear how much maternal care is dysfunctional in BD subjects.

Concepts: Family, Family planning, Bipolar disorder, Mother, Nuclear family, Family therapy, Cinderella effect, Dysfunctional family