SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: Journal francais d'ophtalmologie

28

Periorbital dermoid cysts are benign tumors most often seen in young children. Intraorbital location, though rare, should not be overlooked. Good quality imaging plays a major role in the etiological diagnosis, providing a precise analysis of the location of the lesion, its components, and its effects on adjacent and nearby structures, as well as in planning the surgical approach. The authors report a case of a 46-year-old male with an intraorbital dermoid cyst presenting with progressive left proptosis. Appearance on imaging (CT and MRI) was consistent with intraorbital dermoid cyst. The tumor was extirpated. Histopathologic examination confirmed the diagnosis of dermoid cyst. We also present a review of the literature.

Concepts: Oncology, Anatomical pathology, Benign tumor, Tumor, Cyst, Dermoid cyst, Pilonidal cyst, Teratoma

28

PURPOSE: The administration of topical tacrolimus (FK506) eye drops or ointment is effective in treating certain immunologic corneal diseases and in the prevention of rejection of high-risk corneal grafts. The purpose of this study is to determine the optimal formulation of tacrolimus 0.06% eye drops. A procedure for preparation is presented and discussed. METHODS: Tacrolimus monohydrate powder and virgin castor oil are used in this new formulation. The manufacturing process guarantees consistency of product sterility. Measurement by high-performance liquid chromatography allows precise control of the concentration of tacrolimus. RESULTS: The manufacture and packaging of tacrolimus 0.06% eye drops involve numerous controls allowing for guaranteed sterility and stability. The drops remained sterile and stabile for 28 days after opening regardless of storage conditions and can be stored for 3 months after manufacture. Tolerability studies are currently being performed.

Concepts: Eye, Chromatography, High performance liquid chromatography, Analytical chemistry, Cornea, Lens, Iris, Tacrolimus

27

Ophthalmological involvement in mantle cell lymphoma is rare. An 84-year-old man presented with bilateral proptosis. Orbital biopsy established the diagnosis of mantle cell lymphoma. The diagnosis of mantle cell lymphoma is anatomopathological and immuno-histochemical. Orbital involvement is found most often in advanced stages of the disease, but may be the presenting sign as in the case of our patient. Treatment has improved with the use of rituximab, especially in elderly patients not eligible for autologous hematopoietic stem cell transplant.

Concepts: Cell, Cancer, Medical terms, Patient, Physician, Hematopoietic stem cell transplantation, Hematopoietic stem cell, Mantle cell lymphoma

26

To evaluate the efficiency and safety of intravitreal implant of 0.7mg dexamathasone in visual impairment due to diabetic macular edema (DME).

Concepts: Diabetes mellitus, Retina, Ophthalmology, Diabetic retinopathy, Visual impairment, Blindness, Macular edema

26

Pediatric orbital cellulitis is most often caused by ethmoid sinusitis. We present a description of 4 atypical cases of orbital cellulitis without sinusitis.

Concepts: Sinusitis, Ethmoid sinus

25

To assess the effects of preoperative patient characteristics on clinical outcomes of corneal collagen crosslinking (CXL) in patients with progressive keratoconus.

23

Epiretinal membranes (ERM) have been increasingly characterized with the advent of new optical coherence tomographies (OCTs). We intended to perform a systematic review regarding prognostic factors (PF) of ERM after surgery.

Concepts: Optics, Thought experiment, Epiretinal membrane, Advent

22

Transient monocular blindness is an acute episode of ischemic origin in which one eye has profound visual loss, followed by full recovery within one hour. Transient monocular blindness most often occurs in the setting of retinal ischemia secondary to carotid embolism, but other mechanisms have been reported, including thrombosis (most often in the setting of giant cell arteritis), hemodynamic disorders (secondary to severe carotid stenosis), or vasospasm. Transient monocular blindness is considered a transient ischemic attack originating in the carotid arteries, and must be managed the same as transient ischemic attack involving the brain, in order to prevent a subsequent stroke.

Concepts: Medical terms, Blood vessel, Stroke, Thrombosis, Traumatic brain injury, Ischemia, Embolism, Amaurosis fugax

0

Shear wave elastography (SWE) is a non-invasive diagnostic imaging technique that maps the elastic properties of tissues. This modality is being increasingly developed in other areas of medicine, offering a new type of high-quality ultrasound examination, since it increases specificity and thus improves diagnostic accuracy. This method is similar to manual palpation, showing the elastic properties of biological tissues and providing a kind of reconstruction of the internal structure of soft tissues based on measurement of the response to tissue compression. In ophthalmology, it already appears promising for diagnosis and in evaluating changes in extraocular muscles and orbital tissues in patients with endocrine orbitopathy. Shear wave elastography offers three main innovations: the quantitative aspect, dimensional resolution, and real-time imaging ability. Determination of the utilization rate of this method and its inclusion in the diagnosis of endocrine orbitopathy is still a question and the object of clinical studies currently under way.

0

To compare performance on the EyeSi surgical simulator in 3 training modules by users with different levels of experience in ophthalmology.