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Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]


Mastitis is defined as inflammation of the mammary gland in domestic dairy animals and humans. Salidroside, a major component isolated from Rhodiola rosea L., has potent anti-inflammatory properties, but whether it can be used in mastitis treatment has not yet been investigated. The aim of this study was to assess the protective effects of salidroside against lipopolysaccharide (LPS)-induced mastitis in mice and the mechanism of action.

Concepts: Rhodiola, Mammal, Signal transduction, Anti-inflammatory, Inflammation, Rhodiola rosea


This study compares the expression levels of tumor necrosis factor ligand superfamily member 4 (TNFSF4) and TNF-R-associated factor 2 (TRAF2) mRNAs in peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE) against healthy controls. The association of SLE disease activity index (SLEDAI) and clinical features of SLE with altered expression levels of TNFSF4 and TRAF2 mRNAs were also evaluated.

Concepts: Cyclophosphamide, Lupus erythematosus, Cell nucleus, Glomerulonephritis, Rheumatology, Lupus nephritis, Antiphospholipid syndrome, Systemic lupus erythematosus


Inflammation is believed to be a contributing factor to many chronic diseases. The influence of vitamin D deficiency on inflammation is being explored but studies have not demonstrated a causative effect.

Concepts: Asthma, Vitamin D


Molecular mechanisms underlying the interactions between Pseudomonas aeruginosa, the common opportunistic pathogen in cystic fibrosis individuals, and host induce a number of marked inflammatory responses and associate with complex therapeutic problems due to bacterial resistance to antibiotics in chronic stage of infection.

Concepts: Medicine, Inflammation, Opportunistic infection, Cystic fibrosis, Antibiotic resistance, Immune system, Bacteria, Pseudomonas aeruginosa


In the original publication, author missed to include the financial support from CAPES/PROCAD-2013. The complete funding text should read as follows.

Concepts: Finance


Colorectal cancer (CRC) still represents the third most commonly diagnosed type of cancer in men and women worldwide. CRC is acknowledged as a heterogeneous disease that develops through a multi-step sequence of events driven by clonal selections; this observation is sustained by the fact that histologically similar tumors may have completely different outcomes, including a varied response to therapy.

Concepts: Gregorian chant, Mutation, Infectious disease, Oncology, Colorectal cancer, Immune system, Medicine, Cancer


This study aimed to investigate the anti-inflammatory effects of a novel spirocyclopiperazinium salt compound LXM-15, and explore the underlying mechanisms.

Concepts: Effects unit, Effect


Pro-inflammatory cytokines, such as interleukin (IL)-6, tumour necrosis factor (TNF)α, and monocyte chemoattractant protein (MCP)-1, are often elevated in individuals after acute pancreatitis but what determines their levels is poorly understood. Gut hormones have emerged as possible modulators of inflammatory response. The aim was to investigate the associations between pro-inflammatory cytokines and a comprehensive panel of gut hormones after an episode of acute pancreatitis.

Concepts: Metabolism, Interleukin, Apoptosis, Hormone, Signal transduction, Immune system, Cytokine, Inflammation


Amelotin (AMTN) is an enamel protein that is localized in the basal lamina of ameloblasts in their maturation stage and the internal basal lamina of junctional epithelium (JE) and it is suggested that AMTN could be involved in the dentogingival attachment. To elucidate the transcriptional regulation of human AMTN gene in inflamed gingiva, we have analyzed the effect of tumor necrosis factor-α (TNF-α) on the expression of AMTN gene in Ca9-22 and Sa3 human gingival epithelial cells.

Concepts: Epithelium, RNA, Molecular biology, Protein, Transcription, Gene, DNA, Gene expression


We investigated whether: (1) P2 × 7 receptor activation by its agonist (BzATP) induces articular hyperalgesia in the rat’s knee joint via inflammatory mechanisms and (2) activation of P2 × 7 receptors by endogenous ATP contributes to the articular hyperalgesia induced by bradykinin, TNF-α, IL-1β, CINC-1, PGE2, and dopamine.

Concepts: Second messenger system, Rat, Serotonin