Journal: Human reproduction (Oxford, England)
Are parity and the timing of menarche associated with premature and early natural menopause?
Does the European Society of Human Reproduction and Embryology-European Society for Gynaecological Endoscopy (ESHRE-ESGE) classification of female genital tract malformations significantly increase the frequency of septate uterus diagnosis relative to the American Society for Reproductive Medicine (ASRM) classification?
What is the impact of cancer in females aged ≤39 years on subsequent chance of pregnancy?
Is preconception dietary intake associated with reduced fecundity as measured by a longer time to pregnancy (TTP)?
Is adherence to the Mediterranean diet (MedDiet) associated with better IVF performance in women attempting fertility?
Is self-reported type of underwear worn associated with markers of testicular function among men at a fertility center?
What is the semen quality of young adult men who were conceived 18-22 years ago by ICSI for male infertility?
Do women with BRCA1 or BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-Müllerian hormone (AMH) concentration?
Is consumption of fruits and vegetables with high levels of pesticide residues associated with lower semen quality?
Ovarian insufficiency is a major long-term adverse event, following the administration of a myeloablative conditioning regimen, and occurring in >80% of children and adolescents receiving such treatment for malignant or non-malignant disease. Cryopreservation of ovarian tissue is currently offered to preserve the fertility of these young patients. At least 35 live births have been reported after transplantation of cryopreserved ovarian tissue in adult patients, but the procedure remains unproven for ovarian tissue harvested at a prepubertal or pubertal age. We report here the first live birth after autograft of cryopreserved ovarian tissue in a woman with primary ovarian failure after a myeloablative conditioning regimen as part of a hematopoietic stem cell transplantation performed for homozygous sickle-cell anemia at age 14 years. This first report of successful fertility restoration after the graft of ovarian tissue cryopreserved before menarche offers reassuring evidence for the feasibility of the procedure when performed during childhood.