SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: Endocrinologia, diabetes y nutricion

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Acromegaly is a rare disease with many comorbidities that impair quality of life and limit survival. There are discrepancies in various clinical guidelines regarding diagnosis and postoperative control criteria, as well as screening and optimal management of comorbidities. This expert consensus was aimed at establishing specific recommendations for the Spanish healthcare system. The existing recommendations, the scientific evidence on which they are based, and the main controversies are reviewed. Unfortunately, the low prevalence and high clinical variability of acromegaly do not provide strong scientific evidences. To mitigate this disadvantage, a modified Delphi questionnaire, combining the best available scientific evidence with the collective judgment of experts, was used. The questionnaire, generated after a face-to-face debate, was completed by 17 Spanish endocrinologists expert in acromegaly. A high degree of consensus was reached (79.3%), as 65 of the total 82 statements raised were accepted. Some criteria for diagnosis and postoperative control were identified by this procedure. Regarding comorbidities, recommendations have been established or suggested for screening and management of oncological, cardiovascular, respiratory (sleep apnea), metabolic (dyslipidemia and diabetes), musculoskeletal, and hypopituitarism-related disorders. Consensus recommendations may facilitate and homogenize clinical care to patients with acromegaly in the Spanish health system.

Concepts: Scientific method, Medicine, Critical thinking, Sleep apnea, Prevalence, Evidence, Scientific evidence, Anecdotal evidence

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Endocrine changes due to menopause have been associated to oxidative stress and muscle mass loss. The study objective was to determine the relationship between both variables in early postmenopause.

Concepts: Energy, Muscle atrophy, Sarcopenia

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An epidemiological study conducted between 1988 and 1992 showed iodine deficiency and endemic goiter in the schoolchildren of the autonomous community of the Basque Country.

Concepts: Epidemiology, Sodium chloride, Hypothyroidism, Thyroid, Iodine, Goitre, Basque Country

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Nutritional intake during early ages has been associated to disease onset later in life. This study aimed to assess dietary intake in Spanish university students of health sciences as compared to national recommended dietary intakes (DRIs).

Concepts: Medicine, Health, Human, Nutrition, Death, Student, Health sciences, Dietitian

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Incidence of type 1 diabetes mellitus raises a number of controversies. Our study aim was to contribute to answer the following questions: Is incidence of T1DM increasing? Is age at onset of type 1 diabetes mellitus decreasing? Which are the sex differences? Which are the characteristics in adults?

Concepts: Insulin, Diabetes mellitus type 2, Diabetes mellitus, Diabetes mellitus type 1, Diabetes, Order theory

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To provide practical recommendations to assess and treat osteoporosis in males.

Concepts: Malnutrition, Jürgen Habermas

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The negative impact of hypoglycemia on patients with type 1 diabetes mellitus (T1DM) may lead to development of fear of hypoglycemia. In this study, the original Hypoglycemia Fear Survey (HFS) questionnaire was translated into Spanish, adapted and validated, and variables associated to fear of hypoglycemia in T1DM were analyzed.

Concepts: Immune system, Insulin, Diabetes mellitus type 2, Diabetes mellitus, Diabetes mellitus type 1, Diabetes, Hypoglycemia, Sulfonylurea

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Hyperuricemia is associated to cardiovascular disease. However, the contribution of uric acid (UA) to cardiovascular mortality in diabetic patients is controversial.

Concepts: Diabetes mellitus type 2, Diabetes mellitus, Metabolic syndrome, Uric acid

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Early detection of heterozygous familial hypercholesterolemia (HFH) is needed to prevent premature cardiovascular events. Our aim isto describe the course of an HFH screening detection day in the Northern Cadiz Health Area in Spain and to analyze the data recorded.

Concepts: Myocardial infarction, Atherosclerosis, Coronary artery disease, Cardiovascular disease, Familial hypercholesterolemia, Hypercholesterolemia

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The Prader-Willi syndrome (PWS) is a rare genetic disorder caused by absence of expression of the paternal alleles in región 15q11.2-q13. Obesity and hormonal deficiencies, especially of growth hormone (GH), are the most important signs from the therapeutic viewpoint. Recombinant GH (rGH) is effective in children and represents the mainstay in treatment; by contrast, little evidence in available in adult patients.

Concepts: Immune system, Genetics, Gene expression, Growth hormone, Peptide hormone, Ghrelin, Endocrine gland, Prader–Willi syndrome