SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: Data in brief

155

Here we present data to evaluate potential absorption of Bisphenol A through non-metabolizing tissues of the upper digestive tract. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24 h period in 10 adult male volunteers following ingestion of 30 μg d6-BPA/kg body weight in soup. The pharmacokinetic behavior of BPA and its metabolites in this cohort (rapid absorption, complete elimination, evidence against sublingual absorption) was reported. This Data in Brief article contains the corresponding individual pharmacokinetic data, reports the demographics of the cohort and provides additional details related to the analytical methods employed and is related to [4].

149

In this data article we provide topologies and force field parameters files for molecular dynamics simulations of lipids in the OPLS-aa force field using the GROMACS package. This is the first systematic parameterization of lipid molecules in this force field. Topologies are provided for four phosphatidylcholines: saturated DPPC, mono-cis unsaturated POPC and DOPC, and mono-trans unsaturated PEPC. Parameterization of the phosphatidylcholines was achieved in two steps: first, we supplemented the OPLS force field parameters for DPPC with new parameters for torsion angles and van der Waals parameters for the carbon and hydrogen atoms in the acyl chains, as well as new partial atomic charges and parameters for torsion angles in the phosphatidylcholine and glycerol moieties [1]. Next, we derived parameters for the cis and trans double bonds and the neighboring them single bonds [2]. Additionally, we provide GROMACS input files with parameters describing simulation conditions (md.mdp), which are strongly recommended to be used with these lipids models. The data are associated with the research article “Cis and trans unsaturated phosphatidylcholine bilayers: a molecular dynamics simulation study” [2] and provided as supporting materials.

Concepts: Molecular dynamics, Atom, Chemical bond, Lipid, Lipid bilayer, Lecithin, GROMACS, OPLS

145

This article describes the various chemical components as obtained from the oils in the leaves of Cymbopogon citratus using hydrodistillation and solvent-free microwave extraction methods. Furthermore, extractions of the oils were also carried out with a slight in pH variation and compared, “GC-MS evaluation of C. citratus (DC) Stapf oil obtained using modified hydrodistillation and microwave extraction methods” (Ajayi et al., 2016 [1]). The current article contains one table exhibiting a list of compounds in the four different methods of extraction. Comparative studies amongst the various methods of extraction are highlighted in the table.

Concepts: Chemical compound, Essential oil, Oil, Oils, Cymbopogon, Cymbopogon citratus

143

This article includes data from three prospective longitudinal human cohorts of prenatal marijuana exposure (PME) and offspring outcomes from the fetal period through young adulthood. The table herein contains an overview of the major adverse effects associated with PME from the following human cohorts: (1) The Ottawa Prenatal Prospective Study (OPPS); (2) The Maternal Health Practices and Child Development Study (MHPCD); and (3) The Generation R Study (Gen R). In the OPPS, fetal gestational age was measured and age-appropriate standardized neuropsychological instruments were used to assess neonatal responses, and infant-child and adolescent-young adult cognitive and behavioral skills. In the MHPCD, birth length and weight, neonatal body length, and infant-child sleep, cognition, and behavioral parameters were measured. In the Gen R, birth weight and growth were measured, as were infant-child attention and aggression. The data in this article are in support of our report entitled “Prenatal Cannabis Exposure - The "First Hit” to the Endocannabinoid System" (K.A. Richardson, A.K. Hester, G.L. McLemore, 2016) [13].

Concepts: Psychology, Pregnancy, Infant, Embryo, Prenatal development, Fetus, Obstetrics, Gestational age

142

Data in this article depict patterns of methylation in lung tissues obtained from the offspring of B6129SF1/J dams and 129S1/SvImJ sires exposed in utero to benzo[a]pyrene (BaP) or dibenzo[def,p]chrysene (DBC) as compared to non-exposed offspring. Genome-wide methylation of lung tumors in adult offspring was determined using methylated DNA immunoprecipitation (MeDIP) with the NimbleGen mouse DNA methylation CpG island array. This data article refers to the research article “DNA methylation in lung tissues of mouse offspring exposed in utero to polycyclic aromatic hydrocarbons," [1] in which comprehensive data interpretation and analysis are provided.

Concepts: DNA, Epigenetics, Polycyclic aromatic hydrocarbon, DNA methylation, Methylation, DNA methyltransferase, Bisulfite sequencing, Methylated DNA immunoprecipitation

141

Cell extracts from A549, H460, and U2OS human cancer cell lines treated with cisplatin and docetaxel were analyzed by mass spectrometry (MS) proteomic analysis. The extracts were enriched for cellular signaling proteins using a mix of three different immobilized kinase inhibitors (Purvalanol B, Bisindolylmaleimide X, and ®-3-(4-((1-Phenylethyl)amino)thieno[2,3-d]pyrimidin-6-yl)benzoic acid (SB6-060-05)) on sepharose bead columns. Raw data is deposited in the PRIDE database [1], project number PXD005286. Data presented () shows changes relative to untreated control for each biological replicate for the three cell lines.

Concepts: DNA, Protein, Gene, Cell nucleus, Enzyme, Cell biology, Chemotherapy, Cell culture

136

The data presented in this article are related to the research article entitled “CuO photocathode-embedded semitransparent photoelectrochemical cell” (Patel et al., 2016) [1]. This article describes the growth of Cu oxides films using reactive sputtering and application of CuO photocathode in semitransparent photoelectrochemical cell (PEC). In this data article, physical, optical and electrical properties, and PEC performances data set of the reactively sputtered semitransparent CuO samples are made publicly available to enable extended analyses.

Concepts: Data, Research, Copper, Oxide, Photoelectrochemical cell

134

We studied morphometric features of the spiral structure of the narwhal tusk and show that angular parameters of the arcs of the cementum layer determine the pattern of the spiral structure of the tusk. Given the straight shape of the tusk and the inclined pattern of the arcs of the cementum layer, the angular characteristics of the spiral were determined through the ratio of the legs of a right triangle, which was a basis for calculating the tangent of the angle of inclination. We found the angle of inclination through the arctangent. The tangent of the angle of inclination of the arcs of the spiral of the narwhal tusk is 2.39 ± 0.07, while the angle of inclination is 66.88 ± 0.61°. The indicators reflect the spiral morphology of the narwhal tusk. Researchers can use the data obtained in morphology practices, as well as in modeling the natural spiral structure in biomimetics.

130

We present the bathymetric dataset of a single beam sounding. Surveys were conducted in 25 expeditions of the Atlantic branch of Shirshov Institute of Oceanology RAS in the Russian EEZ area of the southeastern part of the Baltic Sea in the period from 2004 to 2018. Acoustic data were acquired by echo sounders Simrad EA-400SP and Furuno FS-700. The raw sounding data were filtered and corrected by sound velocity values. The dataset is presented as spreadsheets (*.xslx) and GIS point-class shapes (*.shp). The digital elevation model (DEM) of 1: 500 000 scale has been constructed for the entire Russian EEZ on base of the original array of sounding profiles and an open sources bathymetry [1]. DEM is presented by XYZ-grid (*.txt) and GeoTIFF raster (*.tif).

129

In this work we present three-dimensional (3D) measurements of Brillouin scattering spectra of the in-vivo zebrafish larvae eye. This dataset was obtained by Brillouin microscopy, an emerging all-optical and non-contact technique that gives access to material properties through the process of Brillouin scattering. Herein, we share a representative 3D dataset of spectral properties of 48-52 h post-fertilization (hpf) zebrafish embryos. These spectral properties can be related to a complex longitudinal modulus and thus elastic and viscous properties given knowledge of refractive index and material density. The dataset encompasses the crystalline lens as well as several different retinal layers. This data provides a valuable resource as well as a starting point for researchers interested in the mechanobiology of vertebrate eye development.