Discover the most talked about and latest scientific content & concepts.

Journal: Clinical case reports


Diabetes insipidus without perception of thirst, as may follow an anterior communicating artery aneurysm, requires prescription of fluid intake as well as desmopressin. The management goal of maintaining a normal serum sodium is rendered more challenging in a humid subtropical environment, where insensible losses are higher.

Concepts: Polydipsia, Durban, Management, Aneurysm, Earth, Diabetes insipidus, Anterior communicating artery, Climate


Tea interferes with iron absorption and can lead to iron deficiency anemia when consumed in large quantities. The rechallenge effect of green tea on anemia in a middle-aged man emphasizes the potential causal role of this beverage. Lifestyle and dietary habits are important diagnostic considerations in diseases of this type.

Concepts: Iron, Death, Human iron metabolism, Transferrin, Hemoglobin, Iron deficiency anemia


Despite a shift in clinical practice favouring cesarean section for breech presentation, adequate skills are still needed for a safe vaginal breech birth. This case report illustrates the physiological mechanism of vaginal breech birth. The accompanying pictures are a testimony to the “hands-off” approach and could be used for educational purposes.

Concepts: Obstetrics, Caesarean section, Breech birth, Childbirth


Bleeding is a rare complication of direct oral anticoagulant potentially associated with high mortality rates. Biological monitoring is necessary for more than 24 h after idarucizumab antidote therapy in case of bleeding with dabigatran therapy.

Concepts: Warfarin, Dabigatran, Anticoagulant, Mortality rate, Case


Repeated experimental reinfection of two subjects indicates that Helicobacter pylori infection does not promote an immune response protective against future reinfection. Our results highlight the importance of preventing reinfection after eradication, through public health initiatives, and possibly treatment of family members. They indicate difficulties for vaccine development, especially therapeutic vaccines.

Concepts: Immunology, Public health, Bacteria, Vaccine, Smallpox, Helicobacter pylori, Vaccination, Immune system


Ehlers-Danlos syndrome hypermobility type (EDS-HT) is an underdiagnosed genetic connective tissue disorder that causes joint hypermobility and widespread pain. We present a patient with the chief complaint of shoulder pain, a long history of widespread joint pain, and associated comorbidities. EDS-HT provided a unifying diagnosis and direction for management.

Concepts: Arthralgia, Medical terms, Syndromes, Collagen, Connective tissue, Hypermobility, Marfan syndrome, Ehlers-Danlos syndrome


Mutations in the SCN5A gene are linked to both the long QT syndrome 3 and Brugada syndrome with few reports describing an overlapping phenotype. We present a unique case and discuss clinical considerations of a patient concurrently exhibiting such conditions with genetic analysis confirming an SCN5A mutation.

Concepts: Cardiac electrophysiology, DNA, Sudden cardiac death, Long QT syndrome, Channelopathy, Evolution, Sodium channel, Syndromes


Timely diagnosis and prompt initiation of treatment is essential in Lyme carditis to achieve favorable prognosis. Externalized permanent pacemaker with an active fixation lead as supportive pacing modality is a feasible option till complete resolution of conduction block with continued antibiotic therapy.

Concepts: Cardiac electrophysiology, Sinoatrial node


Recently, BAPGM enrichment culture has documented Bartonella bacteremia in previously healthy, “nonimmunocompromised” patients following arthropod exposures. Neurobartonellosis should be among the differential diagnoses for patients with persistent or recurrent neurological symptoms of undetermined etiology. Microbiological and immunological testing should be concurrently pursued to determine whether defective immune function accompanies Bartonella bacteremia.

Concepts: Microbiology, Immunity, Greek loanwords, Bartonella henselae, Immune system, Medical terms, Immunology, Medicine


Nontuberculous mycobacteria infrequently cause disseminated infections in immunocompetent hosts. However, they are increasingly being recognized in immunocompromised patients. We present the case of a 40-year-old HIV-positive male presenting with lymphadenopathies and pancytopenia in whom disseminated infection, with bone marrow involvement by Mycobacterium genavense (M. genavense) was diagnosed.

Concepts: Acid fast bacilli, Corynebacterineae, Mycobacterium genavense, Tuberculosis, Nontuberculous mycobacteria, Bone marrow, Mycobacterium, Immune system