Discover the most talked about and latest scientific content & concepts.

Journal: Circulation


Rates of myocardial infarction in firefighters are increased during fire suppression duties, and are likely to reflect a combination of factors including extreme physical exertion and heat exposure. We assessed the effects of simulated fire suppression on measures of cardiovascular health in healthy firefighters.

Concepts: Cardiovascular disease, Myocardial infarction


Previous studies have yielded inconsistent results for the effects of periconceptional multivitamins containing folic acid and of folic acid food fortification on congenital heart defects (CHDs).

Concepts: Food fortification, Folic acid, Congenital heart disease, Congenital heart defect


-The association between consumption of caffeinated and decaffeinated coffee and risk of mortality remains inconclusive.

Concepts: Decaffeination, Caffeine, Coffee


Survivors of teenage and young adult cancer are acknowledged as understudied. Little is known about their long-term adverse health risks, particularly of cardiac disease that is increased in other cancer populations where cardiotoxic treatments have been used.

Concepts: Actuarial science, Population, Death, Genetic disorder, Senescence, Demography, Cancer, Epidemiology


Poor lifestyle behaviors are leading causes of preventable diseases globally. Added sugars contribute to a diet that is energy dense but nutrient poor and increase risk of developing obesity, cardiovascular disease, hypertension, obesity-related cancers, and dental caries.

Concepts: Dental caries, Stroke, Genetic disorder, Sucrose, Nutrition, Disease, Cancer, Obesity


-A continuous relationship between reductions in low-density lipoprotein cholesterol (LDL-C) and major adverse cardiovascular events (MACE) has been observed in statin and ezetimibe outcomes trials, down to achieved levels of 54 mg/dL. However, it is uncertain whether this relationship extends to LDL-C levels <50 mg/dL. We assessed the relationship between additional LDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), and apolipoprotein B100 (apoB) reductions and MACE among patients within the ODYSSEY trials that compared alirocumab versus controls (placebo/ezetimibe), mainly as add on to maximally tolerated statin.

Concepts: Statin, Cholesterol, Myocardial infarction, Atheroma, Apolipoprotein B, Atherosclerosis, Cardiovascular disease, Low-density lipoprotein


-Human or recombinant apolipoprotein A-I (apoA-I) has been shown to increase high-density lipoprotein-mediated cholesterol efflux capacity and to regress atherosclerotic disease in animal and clinical studies. CSL112 is an infusible, plasma-derived apoA-I that has been studied in normal subjects or those with stable coronary artery disease. This study aimed to characterize the safety, tolerability, pharmacokinetics, and pharmacodynamics of CSL112 in patients with a recent acute myocardial infarction.

Concepts: Stroke, Coronary artery bypass surgery, Coronary artery disease, Artery, Angina pectoris, Atheroma, Myocardial infarction, Atherosclerosis


Physical exertion, anger, and emotional upset are reported to trigger acute myocardial infarction (AMI). In the INTERHEART study, we explored the triggering association of acute physical activity and anger or emotional upset with AMI to quantify the importance of these potential triggers in a large, international population.

Concepts: Obesity, Necrosis, Infarction, Troponin, Atherosclerosis, Myocardial infarction


Among adults, skipping meals is associated with excess body weight, hypertension, insulin resistance, and elevated fasting lipid concentrations. However, it remains unknown whether specific eating habits regardless of dietary composition influence coronary heart disease (CHD) risk. The objective of this study was to prospectively examine eating habits and risk of CHD.

Concepts: Death, Metabolic syndrome, Genetic disorder, Diabetes mellitus, Heart, Nutrition, Obesity, Heart disease


Omega-3 fatty acids from fish oil have been associated with beneficial cardiovascular effects, but their role in modifying cardiac structures and tissue characteristics in patients who have had an acute myocardial infarction while receiving current guideline-based therapy remains unknown.

Concepts: Triglyceride, Blood, Clinical trial, Heart, Eicosapentaenoic acid, Fatty acid, Omega-3 fatty acid, Myocardial infarction