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Journal: Circulation. Cardiovascular quality and outcomes


Multiple studies have attempted to identify the association between multivitamin/mineral (MVM) supplementation and cardiovascular disease (CVD) outcomes, but the benefits remain controversial. We performed a systematic review and meta-analysis of the associations between MVM supplementation and various CVD outcomes, including coronary heart disease (CHD) and stroke.


Extreme temperatures are associated with cardiovascular disease (CVD) deaths. Previous studies have investigated the relative CVD mortality risk of temperature, but this risk is heavily influenced by deaths in frail elderly people. To better estimate the burden of extreme temperatures, we estimated their effects on years of life lost due to CVD.

Concepts: Disease, Statistics, Death, Life, Gerontology, Old age, Ageing, Entropy


The American Heart Association Committee recently developed definitions of “ideal,” “intermediate,” and “poor” cardiovascular health based on 7 cardiovascular disease (CVD) risk factors or health behaviors. This study evaluated the prevalence of “ideal” American Heart Association cardiovascular health metrics from June 2006 to October 2007 in the Kailuan cohort (n=101 510; age 18-98 years) in northern China and its relationship with the 4-year CVD incidence.

Concepts: Epidemiology, Disease, Medical statistics, Blood vessel, Cardiovascular disease, China, Prevalence, Chinese language


Mean blood glucose (BG) during acute myocardial infarction (AMI) is an important predictor of inpatient mortality but does not capture glucose variability (GV), which has been shown to be independently associated with mortality in critically ill patients. Whether GV is associated with in-hospital mortality during AMI, after accounting for mean BG, is unknown.

Concepts: Myocardial infarction, Atherosclerosis, Diabetes mellitus, Blood sugar, Artery, Infarction, Troponin, Necrosis



BACKGROUND: =0.003). Patients with preserved EF had significantly improved 6-month and 8-year survival compared with their reduced EF counterparts.Conclusions-Survival after AVR or AVR+coronary artery bypass grafting was most favorable among patients with preoperative preserved EF. However, patients with mild to moderately depressed EF experienced a substantial survival benefit compared with the natural history of medically treated patients. Furthermore, minor reductions of EF carried equivalent increased risk to those with more compromised function suggesting patients are best served when an AVR is performed before even minor reductions in myocardial function.

Concepts: Myocardial infarction, Cardiology, Heart failure, Ejection fraction, Heart, Aortic valve, Aortic valve replacement, Aortic insufficiency


<0.001) for over 5 years. The result remained significant after Bonferroni adjustment for multiple subgroups (99.4% CI, 0.39-0.88; adjusted P=0.002). All-cause mortality was reduced by EDTA chelation (10% versus 16%; hazard ratio, 0.57; 95% CI, 0.36-0.88; P=0.011), as was the secondary end point (cardiovascular death, reinfarction, or stroke; 11% versus 17%; hazard ratio, 0.60; 95% CI, 0.39-0.91; P=0.017). However, after adjusting for multiple subgroups, those results were no longer significant. The number needed to treat to reduce 1 primary end point over 5 years was 6.5 (95% CI, 4.4-12.7). There was no reduction in events in non-diabetes mellitus (n=1075; P=0.877), resulting in a treatment by diabetes mellitus interaction (P=0.004).

Concepts: Myocardial infarction, Atherosclerosis, Hypertension, Diabetes mellitus, Obesity, Stroke, Hypercholesterolemia, Chelation therapy


BACKGROUND: =0.025). The TM group also showed a 24% risk reduction in the secondary end point (hazard ratio, 0.76; 95% confidence interval, 0.51-0.1.13; P=0.17). There were reductions of 4.9 mm Hg in systolic blood pressure (95% confidence interval -8.3 to -1.5 mm Hg; P=0.01) and anger expression (P<0.05 for all scales). Adherence was associated with survival.Conclusions-A selected mind-body intervention, the TM program, significantly reduced risk for mortality, myocardial infarction, and stroke in coronary heart disease patients. These changes were associated with lower blood pressure and psychosocial stress factors. Therefore, this practice may be clinically useful in the secondary prevention of cardiovascular disease.

Concepts: Blood, Myocardial infarction, Atherosclerosis, Hypertension, Heart, Stroke, Blood pressure, Artery


Poor medication adherence is a pervasive problem in patients with hypertension. Despite research documenting an association between patient-provider communication and medication adherence, there are no empirical data on how the informational and relational aspects of communication affect patient’s actual medication-taking behaviors. The aim of this study was to evaluate the impact of patient-provider communication on medication adherence among a sample of primary care providers and their black and white hypertensive patients.

Concepts: Scientific method, Psychology, Hypertension, Patient, Sociology, Science, Research, Information


We conducted a systematic review to examine the efficacy of the Atkins, South Beach, Weight Watchers (WW), and Zone diets, with a particular focus on sustained weight loss at ≥12 months.

Concepts: Epidemiology, The Canon of Medicine, Cardiovascular disease, Systematic review, Randomized controlled trial, Effectiveness, Efficacy, Dieting