SciCombinator

Discover the most talked about and latest scientific content & concepts.

Journal: Cancer research and treatment : official journal of Korean Cancer Association

158

The response to haloperidol as a first-line neuroleptic and the pattern of neuroleptic rotation after haloperidol failure have not been well defined in palliative care. The purpose of this study was to determine the efficacy of haloperidol as a first-line neuroleptic and the predictors associated with the need to rotate to a second neuroleptic.

Concepts: Cancer, Oncology, Chemotherapy, Palliative care, Frequency, Rotation, Haloperidol, Equator

2

Homeobox (HOX) genes are essential developmental regulators that should normally be in the silenced state in an adult brain. The aberrant expression of HOX genes has been associated with the prognosis of many cancer types, including glioblastoma (GBM). This study examined the identity and role of HOX genes affecting GBM prognosis and treatment resistance.

Concepts: Gene expression, Developmental biology, Homeobox, Brain tumor, Glioblastoma multiforme, Genes, Hox gene, HOXA11

2

The purpose of this study is to report real life experiences of sorafenib therapy for hepatocellular carcinoma (HCC) in Korea, using a subset of data from GIDEON (Global Investigation of therapeutic Decisions in HCC and Of its treatment with sorafeNib); a large, prospective, observational study.

Concepts: Empiricism, Philosophy of science, Knowledge, Reality

1

To determine whether light alcohol drinking increases the risk of cancer by using a meta-analysis of cohort studies because the newly revised 2015 European Code against Cancer 4th edition on alcohol and cancer was based on critical flaws in the interpretation and citation of the previous meta-analyses.

Concepts: Epidemiology

0

Even though the therapeutic gold standard of hilar cholangiocarcinoma(HCCA) resection is cancer-free resection margin(RM), surgical treatment still remains challenging. This study evaluated the prognostic significance of RM status in resected HCCA patients and identified survival prognostic factors.

Concepts: Gold, Gold standard, Cholangiocarcinoma, Resection, Klatskin tumor

0

Low-dose computed tomography (LDCT) has been reported as an effective screening method for lung cancer in high-risk populations. We aimed to examine willingness to be screened among Korean males using LDCT and to determine factors associated with lung cancer screening intentions (LCS) based on the Health Belief Model (HBM).

Concepts: Epidemiology, Cancer, Metastasis, Lung cancer, Cancer staging, Epistemology, Tobacco smoking, Medical test

0

Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT).

Concepts: Medicine, Cancer, Ionizing radiation, Radiation therapy, Radiobiology, Head and neck cancer

0

As the recent term of “financial toxicity” implies, cancer causes a treatment-related financial harm. Financial Aid Program for Cancer Patient (FAPCP) is a government’s financial support for low-income patients in the Republic of Korea. This study aimed to describe FAPCP applicants' condition and to investigate factors influencing financial burden, which would provide the basis for implementing a strategy for FAPCP administration.

Concepts: Cancer, Oncology, Republic of China, Democracy, Poverty reduction

0

Adenoid cystic carcinoma (ACC) of the trachea and bronchus is a rare tumor. Although MYB-NFIB oncogene fusion and Notch1 mutation have been identified in adenoid cystic carcinoma (ACC), little is known about the expression and clinical significance of Notch1 and its target gene fatty acid binding protein 7 (FABP7) in tracheobronchial ACC.

Concepts: DNA, Protein, Gene, Gene expression, Cell, Cancer, Transcription, Nutrition

0

Glioblastoma (GBM) is classified as one of the most aggressive and lethal brain tumor. Great strides have been made in understanding the genomic and molecular underpinnings of GBM, which translated into development of new therapeutic approaches to combat such deadly disease. However, there are only few therapeutic agents that can effectively inhibit GBM invasion in a clinical framework. In an effort to address such challenges, we have generated anti-SEMA3A monoclonal antibody as a potential therapeutic antibody against GBM progression.

Concepts: Immune system, Medicine, Cancer, Monoclonal antibodies, Brain tumor, Glioblastoma multiforme, Agent