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Journal: Cancer research and treatment : official journal of Korean Cancer Association


The response to haloperidol as a first-line neuroleptic and the pattern of neuroleptic rotation after haloperidol failure have not been well defined in palliative care. The purpose of this study was to determine the efficacy of haloperidol as a first-line neuroleptic and the predictors associated with the need to rotate to a second neuroleptic.

Concepts: Cancer, Oncology, Chemotherapy, Palliative care, Frequency, Rotation, Haloperidol, Equator


To determine whether light alcohol drinking increases the risk of cancer by using a meta-analysis of cohort studies because the newly revised 2015 European Code against Cancer 4th edition on alcohol and cancer was based on critical flaws in the interpretation and citation of the previous meta-analyses.

Concepts: Epidemiology


Homeobox (HOX) genes are essential developmental regulators that should normally be in the silenced state in an adult brain. The aberrant expression of HOX genes has been associated with the prognosis of many cancer types, including glioblastoma (GBM). This study examined the identity and role of HOX genes affecting GBM prognosis and treatment resistance.

Concepts: Gene expression, Developmental biology, Homeobox, Brain tumor, Glioblastoma multiforme, Genes, Hox gene, HOXA11


The purpose of this study is to report real life experiences of sorafenib therapy for hepatocellular carcinoma (HCC) in Korea, using a subset of data from GIDEON (Global Investigation of therapeutic Decisions in HCC and Of its treatment with sorafeNib); a large, prospective, observational study.

Concepts: Empiricism, Philosophy of science, Knowledge, Reality


The prevalence of PIK3CA in Chinese breast cancer patients may be underestimated. Therefore, we investigated the distribution of somatic PIK3CA/AKT1 mutations in Chinese breast cancer patients and explored their roles in tumor phenotypes and disease prognosis.

Concepts: Cancer, Disease, Breast cancer, Metastasis, Oncology, Lung cancer, Medical terms, Pleural effusion


This randomized phase III study was designed to compare the efficacy and safety of irinotecan plus cisplatin (IP) over etoposide plus cisplatin (EP) in Korean patients with extensive-disease small-cell lung cancer (SCLC).

Concepts: Epidemiology, Cancer, Lung cancer, Cancer staging, Types of cancer, Carcinoma, Small cell carcinoma, Paraneoplastic syndrome


The purpose of this study was to develop Korean versions of the National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy (NCCN-FACT) Ovarian Symptom Index-18 (NFOSI-18) and FACT/Gynecologic Oncology Group (FACT-GOG) Neurotoxicity 4-item (NTX-4), evaluating their reliability and reproducibility.

Concepts: Metastasis, Psychometrics, Fallopian tube


T category of the eighth edition of the American Joint Committee on Cancer (AJCC) staging system for distal bile-duct carcinoma (DBDC) was changed to include tumor invasion depth measurement, while the N-category adopted a 3-tier classification system based on the number of metastatic nodes.

Concepts: Cancer, Breast cancer, Carcinoma in situ, Lung cancer, Cancer staging, Lymph node, Testicular cancer, American Joint Committee on Cancer


PTEN hamartoma tumor syndrome is a spectrum of disorders characterized by unique phenotypic features including multiple hamartomas caused by mutations of the tumor suppressor gene PTEN. Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome are representative diseases, and both have several common clinical features and differences. Because PTEN mutations are associated with an increased risk of malignancy including breast, thyroid, endometrial, and renal cancers, cancer surveillance is an important element of disease management. We report a germline mutation of the PTEN (c.723dupT, exon 7) identified in a young woman with a simultaneous occurrence of breast cancer, dermatofibrosarcoma protuberans, and follicular neoplasm. This case suggests that it is critical for clinicians to recognize the phenotypic features associated with these syndromes to accurately diagnose them and provide preventive care.

Concepts: Cancer, Mutation, Oncology, DNA repair, Benign tumor, P53, Cowden syndrome, Hamartoma


Data on the efficacy of olanzapine in patients receiving moderately emetogenic chemotherapy (MEC) are limited. This study aimed to evaluate and compare the efficacy of olanzapine versus placebo in controlling nausea and vomiting in patients receiving MEC.

Concepts: Chemotherapy, Serotonin, Vomiting, Gastroenteritis, Nausea