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Journal: Cancer research and treatment : official journal of Korean Cancer Association


The response to haloperidol as a first-line neuroleptic and the pattern of neuroleptic rotation after haloperidol failure have not been well defined in palliative care. The purpose of this study was to determine the efficacy of haloperidol as a first-line neuroleptic and the predictors associated with the need to rotate to a second neuroleptic.

Concepts: Cancer, Oncology, Chemotherapy, Palliative care, Frequency, Rotation, Haloperidol, Equator


Homeobox (HOX) genes are essential developmental regulators that should normally be in the silenced state in an adult brain. The aberrant expression of HOX genes has been associated with the prognosis of many cancer types, including glioblastoma (GBM). This study examined the identity and role of HOX genes affecting GBM prognosis and treatment resistance.

Concepts: Gene expression, Developmental biology, Homeobox, Brain tumor, Glioblastoma multiforme, Genes, Hox gene, HOXA11


The purpose of this study is to report real life experiences of sorafenib therapy for hepatocellular carcinoma (HCC) in Korea, using a subset of data from GIDEON (Global Investigation of therapeutic Decisions in HCC and Of its treatment with sorafeNib); a large, prospective, observational study.

Concepts: Empiricism, Philosophy of science, Knowledge, Reality


To determine whether light alcohol drinking increases the risk of cancer by using a meta-analysis of cohort studies because the newly revised 2015 European Code against Cancer 4th edition on alcohol and cancer was based on critical flaws in the interpretation and citation of the previous meta-analyses.

Concepts: Epidemiology


Uveal melanoma has a very poor prognosis despite successful local primary tumor treatment. In this study, we investigated prognostic factors that more accurately reflected the likelihood of recurrence and survival and delineated a prognostic model that could effectively identify different risk groups based on initial clinical parameters.

Concepts: Melanoma, Nocebo, Prognosis, Uveal melanoma, Recurrence relation, Uvea



The purpose of this study was to compare the clinical and functional outcomes in patients with primary base of tongue (BOT) cancer who received definitive radiotherapy (RT) or surgery followed by radiotherapy (SRT).

Concepts: Medicine, Chemotherapy, Radiation therapy


This study aimed to explore the functions and mechanisms of C-C motif chemokine receptor 6 (CCR6), a gene associated with progression and metastasis of colorectal cancer (CRC), in radiosensitivity of rectal cancer (RC).

Concepts: Cancer, Oncology, Signal transduction, Colorectal cancer, Hereditary nonpolyposis colorectal cancer, Colon, Sigmoidoscopy


The use of prostate-specific antigen as a biomarker for prostate cancer (PC) has been controversial and is, therefore, not used by many countries in their national health screening programs. The biological characteristics of PC in East Asians including Koreans and Japanese are different from those in the Western populations. Potential lifestyle risk factors for PC were evaluated with the aim of developing a risk prediction model.

Concepts: Epidemiology, Cancer, Biology, Prostate cancer, Screening, Korea, Prostate-specific antigen, Korean language