Discover the most talked about and latest scientific content & concepts.

Journal: Arthritis care & research


To determine the dose response to weight loss on clinical and mechanistic outcomes in overweight and obese adults with knee osteoarthritis.


Regular physical activity, including running, is recommended based on known cardiovascular and mortality benefits. However, controversy exists regarding whether running can be harmful to knees. The purpose of this study is to evaluate the relationship of running with knee pain, radiographic osteoarthritis, and symptomatic osteoarthritis.

Concepts: Knee


The objective of this study was to explore the experiences, coping styles and support preferences of male RA patients.

Concepts: Rheumatoid arthritis, Rheumatology, Qualitative research, Arthritis


To determine whether lower thigh muscle specific strength increases risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between thigh muscle specific strength and BMI.

Concepts: Obesity, Mass, Body mass index, Strength of materials, Solid mechanics, Specific strength


To investigate the association between (i) smoking status and (ii) smoking cessation and mortality in patients with rheumatoid arthritis (RA).

Concepts: Cohort study, Epidemiology, Clinical trial, Rheumatoid arthritis, Rheumatology, Smoking cessation


Describe the character and composition of the 2015 U.S. adult rheumatology workforce; evaluate workforce trends; and project supply and demand for clinical rheumatology care 2015-2030.

Concepts: Supply and demand, Photography


Objective Moderate to severe chronic pain affects one in five adults. Pain may increase the risk of mortality but the relationship is unclear. This study investigated whether mortality risk was influenced by pain phenotype, characterised by pain extent or pain impact on daily life. Methods The study population was drawn from two large population cohorts of adults aged ≥50 years; the English Longitudinal Study of Ageing (ELSA) (n=6324) and the North Staffordshire Osteoarthritis Project (NorStOP) (n=10985). Survival analyses (Cox’s proportional hazard models) estimated the risk of mortality in participants reporting “any pain” and then separately according to the extent of pain (total number of pain sites; widespread pain according to American College of Rheumatology (ACR) criteria; widespread pain according to Manchester criteria) and pain impact on daily life (pain interference; and often troubled with pain). Models were cumulatively adjusted for age, sex, education and wealth/adequacy of income. Results After adjustments, the report of any pain (MRR 1.06, 95% CI (0.95, 1.19)) or having widespread pain (ACR 1.07 (0.92, 1.23) or Manchester 1.16 (0.99, 1.36)) was not associated with an increased risk of mortality. Participants who were often troubled with pain (1.29 (1.12, 1.49)) and those that reported “quite a bit” (1.38 (1.20,1.59)) and “extreme” (1.88 (1.54, 2.29)) pain interference had an increased risk of all-cause mortality. Conclusion Pain that interferes with daily life, rather than pain per se was associated with an increased risk of mortality. Future studies should investigate the mechanisms through which pain increases mortality risk. This article is protected by copyright. All rights reserved.

Concepts: Death, Proportional hazards models, Sociology, Gerontology, Ageing, All rights reserved, Chronic pain, Copyright


To investigate the contribution of symptoms of depression to future episodes of low back pain (LBP).

Concepts: Low back pain, Back pain, Symptoms


Studies have demonstrated a link between COPD and inflammation, raising the question whether chronic inflammatory conditions, such as RA, predispose to COPD. Our objective was to evaluate the risk of incident COPD hospitalization in RA compared to the general population.

Concepts: Inflammation, Osteoporosis, Asthma, Pneumonia, Rheumatoid arthritis, Chronic obstructive pulmonary disease


To compare persistence and adherence to triple therapy with nonbiologic disease-modifying antirheumatic drugs (DMARDs) methotrexate (MTX), hydroxychloroquine, and sulfasalazine, versus a tumor necrosis factor inhibitor plus MTX (TNFi+MTX) in patients with rheumatoid arthritis (RA).

Concepts: Rheumatoid arthritis, Methotrexate, Arthritis, Tumor necrosis factor-alpha, Ankylosing spondylitis, Disease-modifying antirheumatic drug, Hydroxychloroquine, Sulfasalazine