Discover the most talked about and latest scientific content & concepts.

Journal: Arthritis care & research


Regular physical activity, including running, is recommended based on known cardiovascular and mortality benefits. However, controversy exists regarding whether running can be harmful to knees. The purpose of this study is to evaluate the relationship of running with knee pain, radiographic osteoarthritis, and symptomatic osteoarthritis.

Concepts: Knee


To determine whether lower thigh muscle specific strength increases risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between thigh muscle specific strength and BMI.

Concepts: Obesity, Mass, Body mass index, Strength of materials, Solid mechanics, Specific strength


To investigate the association between (i) smoking status and (ii) smoking cessation and mortality in patients with rheumatoid arthritis (RA).

Concepts: Cohort study, Epidemiology, Clinical trial, Rheumatoid arthritis, Rheumatology, Smoking cessation


Studies have demonstrated a link between COPD and inflammation, raising the question whether chronic inflammatory conditions, such as RA, predispose to COPD. Our objective was to evaluate the risk of incident COPD hospitalization in RA compared to the general population.

Concepts: Inflammation, Osteoporosis, Asthma, Pneumonia, Rheumatoid arthritis, Chronic obstructive pulmonary disease


To compare persistence and adherence to triple therapy with nonbiologic disease-modifying antirheumatic drugs (DMARDs) methotrexate (MTX), hydroxychloroquine, and sulfasalazine, versus a tumor necrosis factor inhibitor plus MTX (TNFi+MTX) in patients with rheumatoid arthritis (RA).

Concepts: Rheumatoid arthritis, Methotrexate, Arthritis, Tumor necrosis factor-alpha, Ankylosing spondylitis, Disease-modifying antirheumatic drug, Hydroxychloroquine, Sulfasalazine


OBJECTIVE: Our objective was to estimate and compare the prevalence of fibromyalgia by two different methods, in Olmsted County, Minnesota. METHODS: The first method was a retrospective review of medical records of potential cases of fibromyalgia in Olmsted County using Rochester Epidemiology Project (from January 1, 2005, to December 31, 2009) to estimate the prevalence of diagnosed fibromyalgia in clinical practice. The second method was a random survey of adults in Olmsted County using the fibromyalgia research survey criteria to estimate the percentage of responders who met fibromyalgia research survey criteria. RESULTS: Of the 3,410 potential patients identified by the first method, 1,115 had a fibromyalgia diagnosis documented in the medical record by a health care provider. The age- and sex-adjusted prevalence of diagnosed fibromyalgia by this method was 1.1%. By the second method, of the 2,994 people who received the survey by mail, 830 (27.6%) responded and 44 (5.3%) met fibromyalgia research survey criteria. The age- and sex-adjusted prevalence of fibromyalgia in the general population of Olmsted County by this method was estimated at 6.4%. CONCLUSION: To the best of our knowledge, this is the first report of the rate at which fibromyalgia is being diagnosed in a community. This is also the first report of prevalence as assessed by the fibromyalgia research survey criteria. Our results suggest that patients, particularly men, who meet the fibromyalgia research survey criteria are unlikely to have been given a diagnosis of fibromyalgia. © 2012 by the American College of Rheumatology.

Concepts: Health care, Health care provider, Medicine, Statistics, Physical examination, Medical history, Rochester, Minnesota, Olmsted County, Minnesota


Knee osteoarthritis (OA) is a commonly undiagnosed condition and care is often not provided. Pharmacists are uniquely placed for launching a multidisciplinary intervention for knee OA.

Concepts: Osteoarthritis


To investigate the contribution of symptoms of depression to future episodes of low back pain (LBP).

Concepts: Low back pain, Back pain, Symptoms



Fibromyalgia is a disabling, chronic pain condition of unknown etiology. Although many factors have been recognized as important contributors to the pain experiences and functional abilities of fibromyalgia patients, the factors that are most impactful (and therefore represent optimal targets for intervention) are still unclear. The aim of the present study was to examine the pathways among depression, self-efficacy, pain, and physical functioning in a large sample of fibromyalgia patients over a 1-year timeframe.

Concepts: Present, Time, Syndromes, Fibromyalgia, Fatigue, Chronic pain, Myofascial pain syndrome