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Concept: X-Force


The Late Pleistocene Shanidar 1 older adult male Neandertal is known for the crushing fracture of his left orbit with a probable reduction in vision, the loss of his right forearm and hand, and evidence of an abnormal gait, as well as probable diffuse idiopathic skeletal hyperostosis. He also exhibits advanced external auditory exostoses in his left auditory meatus and larger ones with complete bridging across the porus in the right meatus (both Grade 3). These growths indicate at least unilateral conductive hearing (CHL) loss, a serious sensory deprivation for a Pleistocene hunter-gatherer. This condition joins the meatal atresia of the Middle Pleistocene Atapuerca-SH Cr.4 in providing evidence of survival with conductive hearing loss (and hence serious sensory deprivation) among these Pleistocene humans. The presence of CHL in these fossils thereby reinforces the paleobiological and archeological evidence for supporting social matrices among these Pleistocene foraging peoples.

Concepts: Human, Left-wing politics, Auditory system, Right-wing politics, Unilateral hearing loss, Pleistocene, French Revolution, X-Force


We report a case with a very rare complication of transcatheter aortic valve implantation. Rupture of the NovaFlex balloon (Edwards transfemoral balloon catheter) occurred during the inflation of the Edwards SAPIEN valve, resulting in dissection of the right common and external iliac arteries during withdrawal of the balloon catheter. The NovaFlex balloon is a part of the Edwards NovaFlex XT transfemoral delivery system.

Concepts: Right-wing politics, External iliac artery, Aortic valve, Internal iliac artery, Arteries, Iliac artery, Iliac vein, X-Force


We report a rare case of complete rupture of the right femoral nerve at the pelvic level, which was caused by a self-inflicted stab wound. The nerve was surgically reconstructed with use of an autologous sural nerve cable graft. Postoperatively, the patient’s sensorimotor function returned to near normal.

Concepts: Nerves of the lower limb and lower torso, Christian right, X-Force


As of date the two temperature sensitive mutations isolated in pheST operon include pheS5 (G293 →A293 ) and pheT354. Recently, we reported that G673 of pheS defines a hot spot for intragenic suppressors of pheS5. In this investigation, in 13 independent experiments, a collection of temperature sensitive mutants were isolated by localized mutagenesis. Complementation using clones bearing pheS+ , pheT+ , and pheS+ T+ indicated that 34 mutants could harbor lesion(s) in pheS and four could be in pheT and one mutant might be a double mutant. Surprisingly, all the 34 pheS mutants harbored the very same (G293 →A293 ) transition mutation as present in the classical pheS5 mutant. Most unexpectedly, the four pheT mutants isolated harbored the same G1711 →A1711 transition, a mutation which is hitherto unreported. Since all the four pheT mutants were defined by the same G1711 →A1711 base change, we believe that getting other mutations could be hard hitting and therefore it is proposed that G1711 itself could be a “hot spot” for emergence of Ts mutations in pheT and similarly G293 itself could be a “hot spot” for Ts lesions in pheS. These results clearly imply a vital role for Glutamic acid571 (Glu571 ) of PheT and reinforce criticality of Glycine98 (Gly98 ) of PheS in the thermal stability of PheRS enzyme.

Concepts: Mutation, Escherichia coli, Mutant, Site-directed mutagenesis, Mutagenesis, Transition, X-Force, Transversion


A 39-year-old woman with a history of chronic back pain due to spinal haemangiomas, multiple malignancies and depression was brought by Emergency medical servicesS to the emergency centre (EC) after being found unresponsive on the bathroom floor. The patient had an exacerbation of her back pain the previous day for which she admitted to taking double her usual dose of oxycodone, in addition to alprazolam, lorazepam, diphenhydramine and a glass of wine. She reported that she lost consciousness and was down for over 8 hours. In the EC, she complained of right forearm pain which was accompanied by mild diffuse soft-tissue swelling and decreased sensation in the right hand. Radial pulse was intact. Creatine kinase was found to be at 4663 U/L. The patient was found to have acute compartment syndrome and underwent emergent forearm fasciotomy. She eventually regained full function of the right arm.

Concepts: Medicine, Back pain, Pulse, Opioid, Radial artery, Compartment syndrome, Anxiolytic, X-Force


The right ventricular (RV) contractile reserve is a measure of the dynamic function of the RV and is a sensitive indicator of volume load. This can be measured noninvasively using the tricuspid annular plane systolic excursion (TAPSE) during exercise. We studied the RV contractile reserve of patients after tetralogy of Fallot (TOF) repair with varying degree of RV dilation and pulmonary regurgitation (PR), and compared them to a control group.

Concepts: Scientific control, Heart, Measurement, Tricuspid valve, Measure, Tetralogy of Fallot, Regurgitation, X-Force


As emergency physicians, we’re used to asking patients about sensitive topics. We overcame discomfort by practicing questions like “Do you have sex with men, women or both?” until the words flowed smoothly. In lectures, I urge providers to counsel suicidal patients about firearm access, given that reducing lethal means access can save lives.(1,2) But early on, I didn’t know how to talk about firearms without offending my patients. This article is protected by copyright. All rights reserved.

Concepts: Hospital, Law, English-language films, Sentence, All rights reserved, Copyright, Firearm, X-Force


An I-MIBG scan was obtained to evaluate a right adrenal mass in a 10-year-old boy, which showed no elevated activity in the lesion. However, diffuse increased activity was noted in the right forearm with typical manifestation of an “arterial injection.” Different from a prior case report, no symptoms or signs related to arterial injection were observed in our patient.

Concepts: Medical terms, Right-wing politics, X-Force


The aim of this study was to analyze the operator radiation exposure (ORE) and the image quality in a coronary angiography (CA) of the standard left lateral view (LLV) and compare it with an alternative right lateral view (RLV).

Concepts: Atherosclerosis, Cardiology, Left-wing politics, Atheroma, Angiography, Touch and Go Records, X-Force


Objective measures of recovery from football match-play could be useful for assessing athletes' readiness to train, if sensitive to preceding match load.

Concepts: American football, Golf, X-Force, Play from scrimmage, Brazilian football match-fixing scandal