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Concept: World Economic Forum


A meeting on Contemporary Topics in Zebrafish Husbandry and Care was held in the United Kingdom in 2014, with the aim of providing a discussion forum for researchers, animal technologists, and veterinarians from academia and industry to share good practice and exchange ideas. Presentation topics included protocols for optimal larval rearing, implementing the 3Rs (replacement, reduction, and refinement) in large-scale colony management, and environmental enrichment. The audience also participated in a survey of current practice relating to practical husbandry, cryopreservation, and the provision of enrichment.

Concepts: Decolonization, England, Internet forum, Fish, Audience, World Economic Forum, Internet, United Kingdom


According to the World Economic Forum, the diffusion of unsubstantiated rumors on online social media is one of the main threats for our society. The disintermediated paradigm of content production and consumption on online social media might foster the formation of homogeneous communities (echo-chambers) around specific worldviews. Such a scenario has been shown to be a vivid environment for the diffusion of false claim. Not rarely, viral phenomena trigger naive (and funny) social responses-e.g., the recent case of Jade Helm 15 where a simple military exercise turned out to be perceived as the beginning of the civil war in the US. In this work, we address the emotional dynamics of collective debates around distinct kinds of information-i.e., science and conspiracy news-and inside and across their respective polarized communities. We find that for both kinds of content the longer the discussion the more the negativity of the sentiment. We show that comments on conspiracy posts tend to be more negative than on science posts. However, the more the engagement of users, the more they tend to negative commenting (both on science and conspiracy). Finally, zooming in at the interaction among polarized communities, we find a general negative pattern. As the number of comments increases-i.e., the discussion becomes longer-the sentiment of the post is more and more negative.

Concepts: Comment, ZOOM, Civil war, Debut albums, Epistemology, American Civil War, World Economic Forum, Military


In 2006 the Shaw Trust charity found high levels of ignorance and poor preparedness to deal with mental health problems among 480 senior employers in the UK. The UK government, non-governmental organisations and Time to Change (TTC) have since provided relevant assistance to employers.

Concepts: Monarchy of the United Kingdom, Northern Ireland, England, Mental disorder, Philanthropy, World Economic Forum, United Kingdom, House of Commons of the United Kingdom


The UK government committed to undertaking impact assessments of its policies on the health of populations in low and middle-income countries in its cross-government strategy “Health is Global”. To facilitate this process, the Department of Health, in collaboration with the National Heart Forum, initiated a project to pilot the use of a global health impact assessments guidance framework and toolkit for policy-makers. This paper aims to stimulate debate about the desirability and feasibility of global health impact assessments by describing and drawing lessons from the first stage of the project.

Concepts: World Economic Forum, Wales, United Kingdom, Internet, European Union, Evaluation, Government, England


We aimed to develop a predictive model for non-satisfaction following primary total knee replacement (TKR) and to assess its transportability to another health care system. Data for model development were obtained from two UK tertiary hospitals. Model transportation data were collected from Geneva University Hospitals in Switzerland. Participants were individuals undergoing primary TKR with non-satisfaction with surgery after one year the outcome of interest. Multiple imputation and logistic regression modelling with bootstrap backward selection were used to identify predictors of outcome. Model performance was assessed by discrimination and calibration. 64 (14.2%) patients in the UK and 157 (19.9%) in Geneva were non-satisfied with their TKR. Predictors in the UK cohort were worse pre-operative pain and function, current smoking, treatment for anxiety and not having been treated with injected corticosteroids (corrected AUC = 0.65). Transportation to the Geneva cohort showed an AUC of 0.55. Importantly, two UK predictors (treated for anxiety, injected corticosteroids) were not predictive in Geneva. A better model fit was obtained when coefficients were re-estimated in the Geneva sample (AUC = 0.64). The model did not perform well when transported to a different country, but improved when it was re-estimated. This emphasises the need to re-validate the model for each setting/country.

Concepts: Medicine, World Economic Forum, Transport, Imputation, United Kingdom, Knee replacement, Prediction, Regression analysis


Most risk analysis models systematically underestimate the probability and impact of catastrophic events (e.g., economic crises, natural disasters, and terrorism) by not taking into account interconnectivity and interdependence of risks. To address this weakness, we propose the Cascading Alternating Renewal Process (CARP) to forecast interconnected global risks. However, assessments of the model’s prediction precision are limited by lack of sufficient ground truth data. Here, we establish prediction precision as a function of input data size by using alternative long ground truth data generated by simulations of the CARP model with known parameters. We illustrate the approach on a model of fires in artificial cities assembled from basic city blocks with diverse housing. The results confirm that parameter recovery variance exhibits power law decay as a function of the length of available ground truth data. Using CARP, we also demonstrate estimation using a disparate dataset that also has dependencies: real-world prediction precision for the global risk model based on the World Economic Forum Global Risk Report. We conclude that the CARP model is an efficient method for predicting catastrophic cascading events with potential applications to emerging local and global interconnected risks.

Concepts: Hazard, Futurology, Risk management, Risk, Prediction, World Economic Forum, Probability theory, Probability


The 11th UK Stroke Forum Conference, hosted by the Stroke Association, is the largest stroke conference in the UK. It aims to provide nurses and other healthcare professionals with opportunities to share learning and best practice in stroke care and rehabilitation.

Concepts: Nursing, World Economic Forum, United Kingdom, The Stroke Association, Stroke, Health care


Diabetes UK has launched a network of information and support for commissioning and improvement in diabetes care. The network is free to join and offers monthly updates on good practice from around the UK, a forum for sharing ideas and learning, and access to Diabetes UK resources.

Concepts: Microsoft, Decolonization, Ship commissioning, Free-to-air, The Network, World Economic Forum, United Kingdom


Gill Harris reports from this year’s National Equine Forum where a key theme was the importance of collaboration and effective communication in achieving the best outcomes for the health and welfare of the horse and the future of equestrianism in the UK.

Concepts: Future, Outer Hebrides, Nursing, World Economic Forum, Jennifer Warnes, United Kingdom, Internet, Horse


Central nervous system (CNS) diseases and, in particular, mental health disorders, are becoming recognised as the health challenge of the 21(st) century. Currently, at least 10% of the global population is affected by a mental health disorder, a figure that is set to increase year on year. Meanwhile, the rate of development of new CNS drugs has not increased for many years, despite unprecedented levels of investment. In response to this state of affairs, the Collegium Internationale Neuro-Psychopharmacologicum (CINP) convened a Summit to discuss ways to reverse this disturbing trend through new partnerships to accelerate CNS drug discovery. The objectives of the Summit were to explore the issues affecting the value chain (i.e. the chain of activities or stakeholders that a company engages in/with to deliver a product to market) in brain research, thereby gaining insights from key stakeholders and developing actions to address unmet needs; to identify achievable objectives to address the issues; to develop action plans to bring about measurable improvements across the value chain and accelerate CNS drug discovery; and finally, to communicate recommendations to governments, research and development community and other relevant stakeholders. Summit outputs include the following action plans aligned to the pressure points within the brain research-drug development value chain. 1. Code of conduct dealing with conflict of interest issues 2. Prevention, early diagnosis and treatment 3. Linking science and regulation 4. Patient involvement in trial design, definition of endpoints etc 5. Novel trial design 6. Reproduction and confirmation of data 7. Update of intellectual property (IP) laws to facilitate repurposing and combination therapy (low priority) 8. Large-scale, global patient registries 9. Editorials on nomenclature, biomarkers and diagnostic tools 10. Public awareness - brain disease advocates to attend G8 meetings and World Economic Forum (WEF) Annual meetings in Davos, Switzerland. Full details of the discussions that formed the bases for these actions are presented in the main body of this document.

Concepts: Human brain, Mental disorder, Meninges, Psychology, World Economic Forum, Brain, Nervous system, Central nervous system