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Concept: Winston Churchill

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This study examined national trends in 12-month prevalence of major depressive episodes (MDEs) in adolescents and young adults overall and in different sociodemographic groups, as well as trends in depression treatment between 2005 and 2014.

Concepts: Great Depression, Winston Churchill, Treatment for depression, Major depressive episode, Major depressive disorder

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The special relationship between migraine and epilepsy has been recognized for centuries and was formally acknowledged by Gowers in his 1906 lecture “Borderland of Epilepsy.” The term migralepsy was introduced by Lennox and Lennox in 1960, with multiple cases described in the literature since that time. In the ensuing years, the relationship between migraine and epilepsy has proven complex. The 2 conditions have been found to be comorbid with each other, suggesting a common underlying mechanism or genetic tendency. Specific diseases with both phenotypes provide further evidence of a common pathophysiology, and as the mechanism of migraine has been further elucidated, commonalities with seizure have been recognized. The terms “hemicrania epileptica” and “migraine triggered seizure” were defined by the International Headache Society, formalizing the concept that one can lead to the other. However, case reports and case series in the literature reveal that distinguishing between the 2 entities can be challenging. The concept of migralepsy is likely to evolve as greater understanding of both conditions is gained.

Concepts: Lennox International, Tony Blair, NATO, Winston Churchill, United Kingdom – United States relations, Epilepsy, Headaches, Special Relationship

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Despite high prevalence rates of depression in primary care, depressive symptoms are often undetected by physicians. Screening for depression is now recommended as a part of routine primary care; however, recent estimates of rates and patterns of depression screening are lacking in the literature. This study examined national rates and patterns of depression screening among visits to office-based primary care physicians.

Concepts: Winston Churchill, Major depressive disorder, Primary care

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From February 4 to 11, 1945, President Franklin D. Roosevelt of the United States, Soviet Union Premier Joseph Stalin, and British Prime Minister Winston Churchill met near Yalta in Crimea to discuss how post-World War II (WWII) Europe should be organized. Within 2 decades of this conference, all 3 men had died. President Roosevelt died 2 months after the Yalta Conference due to a hemorrhagic stroke. Premier Stalin died 8 years later, also due to a hemorrhagic stroke. Finally, Prime Minister Churchill died 20 years after the conference because of complications due to stroke. At the time of Yalta, these 3 men were the leaders of the most powerful countries in the world. The subsequent deterioration of their health and eventual death had varying degrees of historical significance. Churchill’s illness forced him to resign as British prime minister, and the events that unfolded immediately after his resignation included Britain’s mismanagement of the Egyptian Suez Crisis and also a period of mistrust with the United States. Furthermore, Roosevelt was still president and Stalin was still premier at their times of passing, so their deaths carried huge political ramifications not only for their respective countries but also for international relations. The early death of Roosevelt, in particular, may have exacerbated post-WWII miscommunication between America and the Soviet Union-miscommunication that may have helped precipitate the Cold War.

Concepts: Iron Curtain, United States, Joseph Stalin, Yalta Conference, Winston Churchill, Cold War, World War II, Franklin D. Roosevelt

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The aetiology of depression is multifactorial, with biological, cognitive and environmental factors across the life course influencing risk of a depressive episode. There is inconsistent evidence linking early life development and later depression. The aim of this study was to investigate relationships between low birthweight (LBW), infant neurodevelopment, and acute and chronic stress as components in pathways to depression in adulthood.

Concepts: Life expectancy, Dysthymia, Winston Churchill, Pediatrics, Major depressive disorder, Chronic, Biology

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This study aims to use data from a nationally representative survey to examine the correlates of nicotine dependence among smokers with and without major depressive disorder.

Concepts: Dementia, Nicotine, Winston Churchill, Addiction, Dysthymia, Drug addiction, Major depressive disorder, Alcoholism

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History helps us to become better students, judge wisely, understand change, and most importantly, it tells us who we are. It helps us to understand what happened, why it happened and what its ramifications are. Winston Churchill once said: “Study history, study history. In history lie all the secrets of statecraft.” Here, we take this opportunity to pay our gratitude to our esteemed teachers who worked relentlessly for uplifting of the department of Neurology, PGIMER, Chandigarh; and, narrate chronicles of all those people who made this department reach the heights where it stands today.

Concepts: Anthony Eden, World War II, Clement Attlee, Winston Churchill

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A national survey was designed to better understand factors influencing special interest choices and future aspirations of UK radiology trainees as well astheir perceptions of breast radiology.

Concepts: Winston Churchill, Creative industries, Geometry

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PULSE was a large, observational, multicenter study designed to evaluate the efficacy and safety of agomelatine in the treatment of major depression in patients with cardiovascular disease (CVD).

Concepts: Winston Churchill, Medicine

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