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Concept: University of Colorado Denver


Hispanics are underrepresented in medical research. At the National Lung Screening Trial’s University of Colorado Denver screening center, traditional recruitment methods resulted in enrollment of few Hispanics. In response, the center adopted culturally sensitive recruitment techniques, including use of carefully-crafted bilingual materials. Bilingual interviewers were hired, and persons familiar with culture and language of groups of different Hispanic origin were consulted. Representation of Hispanics among participants enrolled at the Colorado center increased nearly threefold, from 3.3 to 9.4 %, after adoption of these methods. In this manuscript, we report on the specialized recruitment methods that were developed and how they were used to address known barriers to Hispanic recruitment.

Concepts: Culture, California, Arizona, Colorado, New Mexico, Hispanic, University of Colorado Denver, Denver


Handling a rodent disease outbreak in a facility can be a challenge. After the University of Colorado Denver Office of Laboratory Animal Resources enhanced its sentinel monitoring program, > 90% of the animal colonies housed in a vivarium at the Anschutz Medical Campus (with an area of 50,000 net ft(2)), serving the labs of > 250 principal investigators, tested positive for multiple infective agents including mouse parvovirus, fur mites, pinworms and epizootic diarrhea of infant mice. The authors detail the process by which they planned and executed a shutdown and a decontamination of the facility, which involved the rederivation or cryopreservation of > 400 unique genetically modified mouse lines. The authors discuss the aspects of the project that were successful as well as those that could have been improved.

Concepts: Epidemiology, Rat, Rodent, Mouse, Colorado, University of Colorado Denver, Denver, Anschutz Medical Campus


Since 2004, the Clinical Faculty Scholars Program (CFSP) at the University of Colorado Anschutz Medical Campus has provided intensive interdisciplinary mentoring and structured training for early-career clinical faculty from multiple disciplines conducting patient-oriented clinical and outcomes research. This study evaluated the two-year program’s effects by comparing grant outcomes for CFSP participants and a matched comparison cohort of other junior faculty.

Concepts: Comparison, University, Academia, Programming language, Colorado, Imperative programming, University of Colorado Denver, Anschutz Medical Campus


This is a brief report regarding the topics about osteoclasts and bone-resorption presented in ASBMR 2017 held in Colorado convention center in Denver, Colorado, in September 8-11, 2017.

Concepts: University of Colorado Denver, Denver, Colorado Convention Center, Denver Nuggets


This is a brief report summarizing topics in ASBMR 2017 held at Colorado Convention Center in Denver on September 8-11th. In this paper, I report some topics from presentation of basic research(especially osteoclast and bone resorption)in ASBMR 2017.

Concepts: Bone, Osteoclast, Convention, University of Colorado Denver, Denver, Colorado Convention Center, Denver Nuggets


Dr. Robert H. Friesen, (1946-) Professor of Anesthesiology, Children’s Hospital Colorado, University of Colorado, Anschutz Medical Campus, has played a pivotal and pioneering role in the development of pediatric and congenital cardiac anesthesiology. His transformative research included the study of the hemodynamic effects of inhalational and intravenous anesthetic agents in the newborn and the effects of anesthetic agents on pulmonary vascular resistance in patients with pulmonary hypertension. As a model clinician-scientist, educator, and administrator, he changed the practice of pediatric anesthesia and shaped the careers of hundreds of physicians-in-training, imbuing them with his core values of honesty, integrity, and responsibility. Based on a series of interviews with Dr. Friesen, this article reviews a career that advanced pediatric and congenital cardiac anesthesia during the formative years of the specialties.

Concepts: Hospital, Anesthesia, Pulmonary artery, Nitric oxide, Pediatrics, Local anesthetic, University of Colorado Denver, Anschutz Medical Campus


At the University of Colorado, Dr. Gordon Meiklejohn pursed the study of influenza and other respiratory pathogens for an unbroken period of 40 years, under the auspices of the Commission on Influenza of the Armed Forces Epidemiological Board through a series of contracts with the U.S. Army Medical Research and Development Command. Sera, throat washings, and other specimens for diagnosis were sent to Dr. Meiklejohn’s laboratory. After serologic and virologic studies were carried out, aliquots of sera and virus samples were logged in and frozen. Sera were stored at -20°C and virus specimens at -70°C. These specimens became known as the Denver Serum Bank. The Bank supported military research programs and other researchers nationally and internationally until the 1990s when lacking of funding and considerations of administration, space, and cost resulted in the destruction of all specimens.

Concepts: Research, United States Army, Military, Armed forces, Research and development, Colorado, University of Colorado Denver, Military organization


OBJECTIVES:We report the results of a randomized clinical trial of a 3-hour, web-based, tobacco cessation education program, the Web-Based Respiratory Education About Tobacco and Health (WeBREATHe) program, for practicing pediatric respiratory therapists (RTs), registered nurses (RNs), and nurse practitioners (NPs).METHODS:Two hundred fifteen RTs (n = 40), RNs (n = 163), and NPs (n = 12) employed at the Children’s Hospital of Philadelphia and the Children’s Hospital, University of Colorado at Denver, participated in this study. All study activities were completed online. After consenting, participants were randomly assigned to either the training (intervention) or delayed training (control) condition. The training condition consisted of a 3-hour continuing education unit course plus ongoing online resources. Participants were assessed at baseline, 1 week, and 3 months after enrollment.RESULTS:Participants in the training condition were more likely to increase their tobacco cessation intervention behaviors than their delayed training counterparts (F[1, 213] = 32.03, P < .001). Training participants showed significantly greater levels of advise (F[1, 213] = 7.22, P < .001); assess (F[1, 213] = 19.56, P < .001); and particularly assist/arrange (F[1213] = 35.52, P < .001). In addition, training condition participants rated the program highly on measures of consumer satisfaction.CONCLUSIONS:The WeBREATHe program is the first evidence-based education program in tobacco cessation designed specifically for pediatric RTs, RNs, and NPs. Engagement in WeBREATHe increased participants' tobacco cessation-related behaviors.

Concepts: Clinical trial, Informed consent, Randomized controlled trial, Tobacco, Nursing, Continuing education, Children's Hospital of Philadelphia, University of Colorado Denver