SciCombinator

Discover the most talked about and latest scientific content & concepts.

Concept: The Association

448

The US Preventive Services Task Force recently recommended the use of aspirin to prevent colorectal cancer and cardiovascular disease among many US adults. However, the association of aspirin use with the risk for other cancer types and the potential population-wide effect of aspirin use on cancer, particularly within the context of screening, remain uncertain.

Concepts: Cancer, Disease, Cardiovascular disease, Colorectal cancer, The Association, Aspirin

373

Industry sponsors' financial interests might bias the conclusions of scientific research. We examined whether financial industry funding or the disclosure of potential conflicts of interest influenced the results of published systematic reviews (SRs) conducted in the field of sugar-sweetened beverages (SSBs) and weight gain or obesity.

Concepts: Scientific method, Mathematics, Science, Research, The Association, Peer review, Review, Finance

308

To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73-76 years).

Concepts: Magnetic resonance imaging, Cerebral cortex, The Association, Sunshine pop

253

Over the past ten years, unconventional gas and oil drilling (UGOD) has markedly expanded in the United States. Despite substantial increases in well drilling, the health consequences of UGOD toxicant exposure remain unclear. This study examines an association between wells and healthcare use by zip code from 2007 to 2011 in Pennsylvania. Inpatient discharge databases from the Pennsylvania Healthcare Cost Containment Council were correlated with active wells by zip code in three counties in Pennsylvania. For overall inpatient prevalence rates and 25 specific medical categories, the association of inpatient prevalence rates with number of wells per zip code and, separately, with wells per km2 (separated into quantiles and defined as well density) were estimated using fixed-effects Poisson models. To account for multiple comparisons, a Bonferroni correction with associations of p<0.00096 was considered statistically significant. Cardiology inpatient prevalence rates were significantly associated with number of wells per zip code (p<0.00096) and wells per km2 (p<0.00096) while neurology inpatient prevalence rates were significantly associated with wells per km2 (p<0.00096). Furthermore, evidence also supported an association between well density and inpatient prevalence rates for the medical categories of dermatology, neurology, oncology, and urology. These data suggest that UGOD wells, which dramatically increased in the past decade, were associated with increased inpatient prevalence rates within specific medical categories in Pennsylvania. Further studies are necessary to address healthcare costs of UGOD and determine whether specific toxicants or combinations are associated with organ-specific responses.

Concepts: Medicine, Statistics, Petroleum, Statistical significance, The Association, Multiple comparisons, Natural gas, Bonferroni correction

242

 To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial’s outcomes after accounting for source of research funding.

Concepts: Pharmacology, Epidemiology, Randomized controlled trial, The Association, Finance

238

To investigate the association between breast feeding and intergenerational social mobility and the possible mediating role of neurological and stress mechanisms.

Concepts: The Association, Mediation, Sunshine pop, Social mobility

222

 To measure the association between a surgeon’s degree of specialization in a specific procedure and patient mortality.

Concepts: United States, Physician, The Association, Sunshine pop

222

In recent years there has been an exponential increase in tungsten demand, potentially increasing human exposure to the metal. Currently, the toxicology of tungsten is poorly understood, but mounting evidence suggests that both the elemental metal and its alloys have cytotoxic effects. Here, we investigate the association between tungsten and cardiovascular disease (CVD) or stroke using six waves of the National Health and Nutrition Examination Survey (NHANES).

Concepts: Medicine, Health, Disease, Iron, Chemical element, Carbon, The Association, Exponential growth

175

Genetic polymorphism is suggested to be associated with human physical performance. The angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and the α-actinin-3 gene (ACTN3) R577X polymorphism have been most widely studied for such association analysis. However, the findings are frequently heterogeneous. We aim to summarize the associations of ACE I/D and ACTN3 R577X with sport performance by means of meta-analysis.

Concepts: Genetics, Allele, Chromosome, The Association, Polymorphism, Adaptation, Genetic polymorphism, Julian Huxley

173

To examine whether there is a difference in the association between high pulse pressure and proteinuria, independent of other blood pressure (BP) indices, such as systolic or diastolic BP, among subjects with diabetes, prediabetes, or normal glucose tolerance.

Concepts: Nutrition, Insulin, Cardiology, Blood pressure, Glucose tolerance test, The Association, Ventricle, Pulse pressure