SciCombinator

Discover the most talked about and latest scientific content & concepts.

Concept: Systematic review

673

 To examine the traditional diet-heart hypothesis through recovery and analysis of previously unpublished data from the Minnesota Coronary Experiment (MCE) and to put findings in the context of existing diet-heart randomized controlled trials through a systematic review and meta-analysis.

Concepts: Experimental design, Epidemiology, Evidence-based medicine, Systematic review, Randomized controlled trial, Evaluation methods, Hypothesis, Meta-analysis

486

422

To reanalyse SmithKline Beecham’s Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The reanalysis under the restoring invisible and abandoned trials (RIAT) initiative was done to see whether access to and reanalysis of a full dataset from a randomised controlled trial would have clinically relevant implications for evidence based medicine.

Concepts: The Canon of Medicine, Systematic review, Randomized controlled trial, Avicenna, Major depressive disorder, Paroxetine, GlaxoSmithKline, Beecham

414

The effects of probiotic supplementation on fecal microbiota composition in healthy adults have not been well established. We aimed to provide a systematic review of the potential evidence for an effect of probiotic supplementation on the composition of human fecal microbiota as assessed by high-throughput molecular approaches in randomized controlled trials (RCTs) of healthy adults.

Concepts: Epidemiology, Gut flora, Evidence-based medicine, Systematic review, Randomized controlled trial, Effectiveness, Pharmaceutical industry, Meta-analysis

406

Dietary guidelines recommend avoiding foods high in saturated fat. Yet, emerging evidence suggests cardiometabolic benefits of dairy products and dairy fat. Evidence on the role of butter, with high saturated dairy fat content, for total mortality, cardiovascular disease, and type 2 diabetes remains unclear. We aimed to systematically review and meta-analyze the association of butter consumption with all-cause mortality, cardiovascular disease, and diabetes in general populations.

Concepts: Nutrition, Diabetes mellitus type 2, Systematic review, Milk, Fat, Butter, Saturated fat, Dairy product

366

Whether light-to-moderate alcohol consumption is protective against stroke, and whether any association differs by stroke type, is controversial. We conducted a meta-analysis to summarize the evidence from prospective studies on alcohol drinking and stroke types.

Concepts: Evidence-based medicine, Systematic review, Meta-analysis, Drinking culture, Type, Seventh-day Adventist Church

349

248

Despite growing recognition of neglectful, abusive, and disrespectful treatment of women during childbirth in health facilities, there is no consensus at a global level on how these occurrences are defined and measured. This mixed-methods systematic review aims to synthesize qualitative and quantitative evidence on the mistreatment of women during childbirth in health facilities to inform the development of an evidence-based typology of the phenomenon.

Concepts: Evidence-based medicine, Systematic review, Randomized controlled trial, Qualitative research, Neglect

246

Previous meta-analyses comparing the efficacy of psychotherapeutic interventions for depression were clouded by a limited number of within-study treatment comparisons. This study used network meta-analysis, a novel methodological approach that integrates direct and indirect evidence from randomised controlled studies, to re-examine the comparative efficacy of seven psychotherapeutic interventions for adult depression.

Concepts: Comparison, Evidence-based medicine, Systematic review, Randomized controlled trial, Meta-analysis, Publication bias, Cultural studies, Direct examination

242

To review the evidence for the short term association between air pollution and stroke.

Concepts: Evidence-based medicine, Systematic review, Meta-analysis, Term, Finance