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Concept: Second Intifada

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Coeliac disease is an important clinical disorder affecting the human gastrointestinal tract leading to multiple signs and symptoms in different body organs. This disease was the subject of a cross sectional descriptive-analytic study conducted in the Gaza Strip during 2010. Objectives were oriented to identify and verify several variables and attributes affecting the prognosis of coeliac disease in the patients. Ninety five children out of 113 patients were arranged into two groups according to age from 2 to 11 years and from 12 to 18 years old. Results showed the poor interest of health professionals regarding coeliac disease in the Gaza Strip. The mean age of study population was 5.47 years for males and 8.93 years for females. The lifestyle of coeliac patients was directly proportional with better nutritional indictors. Poor recognition of the emblem illustrating gluten in foods implicates effective health awareness or promotion. The more knowledgeable patients or mothers (P = 0.036) were the more compliant. The compliance to giving gluten free foods outside home was statistically significant (P = 0.037). Similarly, cautious approach when buying foods or detergents (P = 0.011). According to BMI 74.4%, 23.4% and 3.2% of all patients were normal, underweight and overweight respectively. Albumin blood level was normal in 32.6% and low in 67.4%. Meanwhile, blood calcium level was normal in 76.8%, low in 21.1% and high in 2.1% of all patients. Conclusion: The study showed that recreation and social activities for coeliac patients are substantially missing in the Gaza Strip. Moreover, the study proved that AEI is a reliable centre for care of coeliac disease patients and conducting relevant studies. Recommendation: There is a need for thorough and continuous community and institutional mobilization regarding coeliac disease in the Gaza Strip and in Palestine.

Concepts: Hamas, Coeliac disease, Second Intifada, Gaza, Palestinian National Authority, Palestinian territories, Gaza Strip, Gluten-free diet

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BACKGROUND: β-Thalassemia is a disorder caused by mutations at the hemoglobin β-gene (HBB) locus. Its most important manifestation, the major form, is characterized by severe hypochromic and hemolytic anemia and is inherited in an autosomal recessive mode. In Gaza Strip, Palestine 0.02% of the population has been identified as β-thalassemia major. DESIGN AND METHODS: An assessment of mutations was performed in 49 transfusion dependent patients with β-thalassemia major and in 176 β-thalassemia carriers diagnosed with a mean erythrocyte cell volume (MCV) <80fl and a proportion of HbA(2)>3.5%. In addition 39 individuals suspicious for β-thalassemia carrier status due to a reduced MCV (<80fl) but a normal HBA(2) were screened. RESULTS: By screening with three hybridization assays a proportion of 80% of the thalassemic chromosomes from patients and carriers was identified to carry five different mutations of the hemoglobin (Hb) β-gene. Subsequent DNA sequencing confirmed these and revealed further 9% of the chromosomes to be affected by other mutations. In addition six chromosomes from suspicious carriers were detected to carry β-thalassemia mutations. Of the 15 different HBB mutations identified the variant IVS-I-110 G>A was the most frequent mutation identified in 34% of the thalassemic chromosomes, followed by IVS-I-1 G>A, IVS-I-6 T>C, Codon 39 C>T, and Codon 37 G>A. Three novel HBB variants were discovered by direct sequencing of the gene: 5' UTR-50 (-/G), 5' UTR-43 C>T, and IVS-II-26 T>G. CONCLUSIONS: The spectrum of HBB mutations described is of the Mediterranean type whereby the allele frequencies of the most common mutations differ from those, which were previously described for the population of the Gaza Strip and other Palestinian populations. The data presented may promote the introduction of molecular testing to the Palestinian premarital screening program for β-thalassemia in Gaza Strip, which will improve the screening protocol and genetic counseling in the future.

Concepts: Second Intifada, Hamas, Gaza, Palestinian National Authority, Palestinian territories, Israel, DNA, Gaza Strip

20

In societies involved in an intractable conflict, there are strong socio-psychological barriers that contribute to the continuation and intractability of the conflict. Based on a unique field study conducted in the context of the Israeli-Palestinian conflict, we offer a new avenue to overcome these barriers by exposing participants to a long-term paradoxical intervention campaign expressing extreme ideas that are congruent with the shared ethos of conflict. Results show that the intervention, although counterintuitive, led participants to express more conciliatory attitudes regarding the conflict, particularly among participants with center and right political orientation. Most importantly, the intervention even influenced participants' actual voting patterns in the 2013 Israeli general elections: Participants who were exposed to the paradoxical intervention, which took place in proximity to the general elections, reported that they tended to vote more for dovish parties, which advocate a peaceful resolution to the conflict. These effects were long lasting, as the participants in the intervention condition expressed more conciliatory attitudes when they were reassessed 1 y after the intervention. Based on these results, we propose a new layer to the general theory of persuasion based on the concept of paradoxical thinking.

Concepts: Gaza War, Proposals for a Palestinian state, Second Intifada, Idea, Peace, Elections, Voting, Election

14

The United Nations Relief and Works Agency for Palestine refugees in the Near East (UNRWA) has periodically estimated infant mortality rates among Palestine refugees in Gaza. These surveys have recorded a decline from 127 per 1000 live births in 1960 to 20.2 in 2008.

Concepts: Demography, Yasser Arafat, United Nations Relief and Works Agency for Palestine Refugees in the Near East, Second Intifada, Gaza, Infant mortality, Hamas, Gaza Strip

12

The late president of the Palestinian Authority, Yasser Arafat, died in November 2004 in Percy Hospital, one month after having experienced a sudden onset of symptoms that included severe nausea, vomiting, diarrhoea and abdominal pain and which were followed by multiple organ failure. In spite of numerous investigations performed in France, the pathophysiological mechanisms at the origin of the symptoms could not be identified. In 2011, we found abnormal levels of polonium-210 ((210)Po) in some of Arafat’s belongings that were worn during his final hospital stay and which were stained with biological fluids. This finding led to the exhumation of Arafat’s remains in 2012. Significantly higher (up to 20 times) activities of (210)Po and lead-210 ((210)Pb) were found in the ribs, iliac crest and sternum specimens compared to reference samples from the literature (p-value <1%). In all specimens from the tomb, (210)Po activity was supported by a similar activity of (210)Pb. Biokinetic calculations demonstrated that a (210)Pb impurity, as identified in a commercial source of 3MBq of (210)Po, may be responsible for the activities measured in Arafat's belongings and remains 8 years after his death. The absence of myelosuppression and hair loss in Mr Arafat's case compared to Mr Litvinenko's, the only known case of malicious poisoning with (210)Po, could be explained by differences in the time delivery-scheme of intake. In conclusion, statistical Bayesian analysis combining all the evidence gathered in our forensic expert report moderately supports the proposition that Mr Arafat was poisoned by (210)Po.

Concepts: Fatah, Hamas, Mahmoud Abbas, Gaza Strip, Palestinian people, Second Intifada, Palestinian National Authority, Yasser Arafat

11

Metal contamination of humans in war areas has rarely been investigated. Weaponry’s heavy metals become environmentally stable war remnants and accumulate in living things. They also pose health risks in terms of prenatal intake, with potential long term risks for reproductive and children’s health. We studied the contribution of military attacks to the load of 23 metals in the hair of Palestinian women in the Gaza Strip, who were pregnant at the time of the military attacks in 2014, and their newborns. We compared the metal load in the mothers with values for adult hair from outside the war area (RHS) as the reference. We investigated heavy metals trans-passing in utero, and assessed if the heavy metal intake could derive from sources unrelated to the war.

Concepts: Second Intifada, Gaza, Palestinian territories, Israel, Palestinian National Authority, Childbirth, Heavy metal music, Gaza Strip

5

Humanity is facing a biodiversity crisis. To solve environmental problems, we bring people from Israel, Jordan, and the Palestinian Authority to the same table. Conservation efforts are beneficial for all communities and facilitate constructive dialog across divides in conflict zones. This pleads for the integration of nature conservation into peacebuilding interventions.

Concepts: Gaza Strip, Jerusalem, Palestinian National Authority, Second Intifada, Palestinian territories, Yasser Arafat, Palestinian people, Israel

2

Fostering perceptions of group malleability (teaching people that groups are capable of change and improvement) has been shown to lead to short-term improvements in intergroup attitudes and willingness to make concessions in intractable conflicts. The present study, a field intervention involving 508 Israelis from three locations in Israel, replicated and substantially extended those findings by testing the durability of a group malleability intervention during a 6-month period of frequent violence. Three different 5-hour-long interventions were administered as leadership workshops. The group malleability intervention was compared with a neutral coping intervention and, importantly, with a state-of-the-art perspective-taking intervention. The group malleability intervention proved superior to the coping intervention in improving attitudes, hope, and willingness to make concessions, and maintained this advantage during a 6-month period of intense intergroup conflict. Moreover, it was as good as, and in some respects superior to, the perspective-taking intervention. These findings provide a naturalistic examination of the potential of group malleability interventions to increase openness to conflict resolution.

Concepts: Heidelberg Institute for International Conflict Research, Zionism, Second Intifada, Dispute resolution, Time, Better, Organizational conflict, Improve

2

We hypothesized that an adaptive form of emotion regulation-cognitive reappraisal-would decrease negative emotion and increase support for conflict-resolution policies. In Study 1, Israeli participants were invited to a laboratory session in which they were randomly assigned to either a cognitive-reappraisal condition or a control condition; they were then presented with anger-inducing information related to the Israeli-Palestinian conflict. Participants in the reappraisal condition were more supportive of conciliatory policies and less supportive of aggressive policies compared with participants in the control condition. In Study 2, we replicated these findings in responses to a real political event (the recent Palestinian bid for United Nations recognition). When assessed 1 week after training, participants trained in cognitive reappraisal showed greater support for conciliatory policies and less support for aggressive policies toward Palestinians compared with participants in a control condition. These effects persisted when participants were reassessed 5 months after training, and at both time points, negative emotion mediated the effects of reappraisal.

Concepts: Israel, Fatah, Conflict, First Intifada, Proposals for a Palestinian state, Oslo Accords, Second Intifada, 1948 Palestinian exodus

1

The majority of Gazans who were killed or injured in the 2014 Israel-Gaza war were civilians, and one-fourth of the population were internally displaced. As the Gaza Strip is a small territory, the whole population was exposed to the war and its effects on the health care system, supplies and infrastructure. Our aim was to assess the overall, sex and age-group mortality in Gaza for the period July-September 2014 that was not caused by war injuries, and the proportion of non-trauma deaths among adults that occurred outside hospital wards. A comparison was made with the mortality for the same period in 2013.

Concepts: Israel's unilateral disengagement plan, Israel, Palestinian territories, Hamas, Gaza, Second Intifada, Palestinian National Authority, Gaza Strip