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Concept: Romanian language

203

We describe a new taxon of medium-sized (wing span ca. 3 m) azhdarchid pterosaur from the Upper Cretaceous Transylvanian Basin (Sebeş Formation) of Romania. This specimen is the most complete European azhdarchid yet reported, comprising a partially articulated series of vertebrae and associated forelimb bones. The new taxon is most similar to the Central Asian Azhdarcho lancicollis Nessov but possesses a suite of autapomorphies in its vertebrae that include the relative proportions of cervicals three and four and the presence of elongated prezygapophyseal pedicles. The new taxon is interesting in that it lived contemporaneously with gigantic forms, comparable in size to the famous Romanian Hatzegopteryx thambema. The presence of two distinct azhdarchid size classes in a continental depositional environment further strengthens suggestions that these pterosaurs were strongly linked to terrestrial floodplain and wooded environments. To support this discussion, we outline the geological context and taphonomy of our new specimen and place it in context with other known records for this widespread and important Late Cretaceous pterosaurian lineage.

Concepts: Cretaceous, Pterosaur, Azhdarchidae, Romania, Romanian language, Late Cretaceous, Quetzalcoatlus, Hatzegopteryx

27

A FRAX(®) model for Romania calibrated to the total Romanian population was released June 1, 2011. This article describes the data used to develop the Romanian FRAX model and illustrates its features compared to models for other countries. Age- and sex-stratified hip fracture incidence rates and mortality rates for 2010 were extracted from nationwide databases from the age of 40 years. For other major fractures, Romanian incidence rates were imputed, using Swedish ratios for hip to other major osteoporotic fracture (humerus, forearm, and clinically symptomatic vertebral fractures). Fracture incidence rates increased with increasing age: for hip fracture, incidence rates were higher among younger men than women but with a female preponderance from the age of 65 years. The 10-year probability of hip or major fracture was increased in patients with a clinical risk factor (CRF), lower BMI, female gender, higher age, and decreased BMD T score. Of the CRFs, a parental hip fracture accounted for the greatest increase in 10-year fracture probability. The Romanian FRAX tool is the first country-specific fracture prediction model. It is based on the original FRAX methodology, which has been externally validated in several independent cohorts. Despite some limitations, the strengths make the Romanian FRAX tool a good candidate for implementation into clinical practice.

Concepts: Osteoporosis, Epidemiology, Bone fracture, Romania, Transylvania, Romanian language, Romanians, History of Romania

17

The Ashkenazi Jewish (AJ) population is important in genetics due to its high rate of Mendelian disorders. AJ appeared in Europe in the 10th century, and their ancestry is thought to comprise European (EU) and Middle-Eastern (ME) components. However, both the time and place of admixture are subject to debate. Here, we attempt to characterize the AJ admixture history using a careful application of new and existing methods on a large AJ sample. Our main approach was based on local ancestry inference, in which we first classified each AJ genomic segment as EU or ME, and then compared allele frequencies along the EU segments to those of different EU populations. The contribution of each EU source was also estimated using GLOBETROTTER and haplotype sharing. The time of admixture was inferred based on multiple statistics, including ME segment lengths, the total EU ancestry per chromosome, and the correlation of ancestries along the chromosome. The major source of EU ancestry in AJ was found to be Southern Europe (≈60-80% of EU ancestry), with the rest being likely Eastern European. The inferred admixture time was ≈30 generations ago, but multiple lines of evidence suggest that it represents an average over two or more events, pre- and post-dating the founder event experienced by AJ in late medieval times. The time of the pre-bottleneck admixture event, which was likely Southern European, was estimated to ≈25-50 generations ago.

Concepts: European Union, Madeira, Europe, Italian language, Estonia, Eastern Europe, Western Europe, Romanian language

12

As a major crossroads between Asia and Europe, Romania has experienced continuous migration and invasion episodes. The precise routes may have been shaped by the topology of the territory and had diverse impacts on the genetic structure of mitochondrial DNA (mtDNA) in historical Romanian provinces. We studied 714 Romanians from all historical provinces, Wallachia, Dobrudja, Moldavia, and Transylvania, by analyzing the mtDNA control region and coding markers to encompass the complete landscape of mtDNA haplogroups.

Concepts: DNA, Hungary, Romania, Transylvania, Romanian language, Wallachia, Romanians, Moldavia

4

Moldova has a rich historical and cultural heritage, which may be reflected in the current genetic makeup of its population. To date, no comprehensive studies exist about the population genetic structure of modern Moldavians. To bridge this gap with respect to paternal lineages, we analyzed 37 binary and 17 multiallelic (STRs) polymorphisms on the non-recombining portion of the Y chromosome in 125 Moldavian males. In addition, 53 Ukrainians from eastern Moldova and 54 Romanians from the neighboring eastern Romania were typed using the same set of markers. In Moldavians, 19 Y chromosome haplogroups were identified, the most common being I-M423 (20.8%), R-M17* (17.6%), R-M458 (12.8%), E-v13 (8.8%), R-M269* and R-M412* (both 7.2%). In Romanians, 14 haplogroups were found including I-M423 (40.7%), R-M17* (16.7%), R-M405 (7.4%), E-v13 and R-M412* (both 5.6%). In Ukrainians, 13 haplogroups were identified including R-M17 (34.0%), I-M423 (20.8%), R-M269* (9.4%), N-M178, R-M458 and R-M73 (each 5.7%). Our results show that a significant majority of the Moldavian paternal gene pool belongs to eastern/central European and Balkan/eastern Mediterranean Y lineages. Phylogenetic and AMOVA analyses based on Y-STR loci also revealed that Moldavians are close to both eastern/central European and Balkan-Carpathian populations. The data correlate well with historical accounts and geographical location of the region and thus allow to hypothesize that extant Moldavian paternal genetic lineages arose from extensive recent admixture between genetically autochthonous populations of the Balkan-Carpathian zone and neighboring Slavic groups.

Concepts: DNA, Gene, Biology, Population genetics, Y chromosome, Romania, Romanian language, Moldova

3

This article summarizes the 2012 European Renal Association-European Dialysis and Transplant Association Registry Annual Report (available at www.era-edta-reg.org) with a specific focus on older patients (defined as ≥65 years).

Concepts: Nephrology, French language, Romanian language, Annual report

3

Biosimilar insulins are likely to enter clinical practice in Europe in the near future. It is important that clinicians are familiar with and understand the concept of biosimilarity and how a biosimilar may differ from its reference product. This article provides an overview of biosimilars, the European regulatory requirements for biosimilars and safety issues. It also summarises the current biosimilars approved in Europe and key clinical issues associated with the use of biosimilar insulins.

Concepts: Clinical trial, Europe, Clinical research, Drug development, The Current, The Europeans, Romance languages, Romanian language

2

The WHO Global Code of Practice on the International Recruitment of Health Personnel provides for guidance in health workforce management and cooperation in the international context. This article aims to examine whether the principles of the voluntary WHO Global Code of Practice can be applied to trigger health policy decisions within the EU zone of free movement of persons.

Concepts: European Union, Management, Policy, French language, Business ethics, Governance, 2003 albums, Romanian language

2

To analyze independently in men and women the incidence rate of and risk factors for hip fracture in a southern European population. Illiteracy, dementia, clinically significant depression and disability were factors to receive special emphasis.

Concepts: Osteoporosis, Epidemiology, Medical statistics, Gender, Sociology, Gender role, Gender identity, Romanian language

2

Several countries have set up youth-friendly-health-services. Relatively little is known about approaches to systematically assess their performance against set standards in terms of quality and coverage and define improvement activities based on the findings. The objective of this paper is to fill this gap and to describe the methods and findings of an external review of youth-friendly-health-services in Moldova and the use of the findings to support further planning.

Concepts: Evaluation, Management, Republic, Support, Technical support, Romanian language, Moldova, Transnistria