- Proceedings of the National Academy of Sciences of the United States of America
- Published over 1 year ago
Evidence suggests that light and circadian rhythms profoundly influence the physiologic capacity with which an organism responds to stress. However, the ramifications of light spectrum on the course of critical illness remain to be determined. Here, we show that acute exposure to bright blue spectrum light reduces organ injury by comparison with bright red spectrum or ambient white fluorescent light in two murine models of sterile insult: warm liver ischemia/reperfusion (I/R) and unilateral renal I/R. Exposure to bright blue light before I/R reduced hepatocellular injury and necrosis and reduced acute kidney injury and necrosis. In both models, blue light reduced neutrophil influx, as evidenced by reduced myeloperoxidase (MPO) within each organ, and reduced the release of high-mobility group box 1 (HMGB1), a neutrophil chemotactant and key mediator in the pathogenesis of I/R injury. The protective mechanism appeared to involve an optic pathway and was mediated, in part, by a sympathetic (β3 adrenergic) pathway that functioned independent of significant alterations in melatonin or corticosterone concentrations to regulate neutrophil recruitment. These data suggest that modifying the spectrum of light may offer therapeutic utility in sterile forms of cellular injury.
A basic premise of the recently proffered color-in-context model is that the influence of color on psychological functioning varies as a function of the psychological context in which color is perceived. Some research has examined the appetitive and aversive implications of viewing the color red in romance- and achievement-relevant contexts, respectively, but in all existing empirical work approach and avoidance behavior has been studied in separate tasks and separate experiments. Research is needed to directly test whether red influences the same behavior differently depending entirely on psychological context.
Migraine headache is uniquely exacerbated by light. Using psychophysical assessments in patients with normal eyesight we found that green light exacerbates migraine headache significantly less than white, blue, amber or red lights. To delineate mechanisms, we used electroretinography and visual evoked potential recording in patients, and multi-unit recording of dura- and light-sensitive thalamic neurons in rats to show that green activates cone-driven retinal pathways to a lesser extent than white, blue and red; that thalamic neurons are most responsive to blue and least responsive to green; and that cortical responses to green are significantly smaller than those generated by blue, amber and red lights. These findings suggest that patients' experience with colour and migraine photophobia could originate in cone-driven retinal pathways, fine-tuned in relay thalamic neurons outside the main visual pathway, and preserved by the cortex. Additionally, the findings provide substrate for the soothing effects of green light.
Based on 2,2':6',2'‘-terpyridine ligands (), five terpyridine derivatives, namely 4’-carbazol-9-yl-2,2':6',2'‘-terpyridine (), 4’-diphenylamino-2,2':6',2'‘-terpyridine (), 4’-bis(4-tert-butylphenyl)amino-2,2':6',2'‘-terpyridine (), 4’-[naphthalen-1-yl-(phenyl)amino]-2,2':6',2'‘-terpyridine (), 4’-[naphthalen-2-yl(phenyl)amino]-2,2':6',2'‘-terpyridine () and their corresponding Re(i) complexes (n = 1-6) have been synthesized and characterized by elemental analysis and (1)H NMR spectroscopy. The X-ray crystal structure of has also been obtained. The luminescence spectra of , obtained in CH(2)Cl(2) solution at room temperature, show strong dπ (Re) → π* (diimine) MLCT character (λ(max) ∼ 600 nm) and a small red shift relative to . This, confirmed by the study of the triplet energy levels of the ligands at low temperature (77 K rigid matrix), indicates that the introduction of electron-donating moieties on the terpyridine unit decreases the triplet levels of the ligands, leading to a reduction of the energy gap between d and π* orbitals. In the solid state, upon MLCT excitation, all the complexes show an even stronger emission and a blue spectral shift (λ(max) ∼ 550 nm) compared to those obtained in solution.
ETHNOPHARMACOLOGICAL RELEVANCE: Red edible bird’s nests are regarded as of higher beneficial value for health and hence fetch a higher price than the white ones. Their red colour remains a myth. AIM OF THE STUDY: To determine if white edible bird’s nests can turn red by vapours generated from sodium nitrite in acidic conditions and by vapours from ‘bird soil’. MATERIALS AND METHODS: White edible bird’s nests were exposed to vapours from sodium nitrite dissolved in 2% HCl or from ‘bird soil’ in hot and humid conditions. CONCLUSIONS: Vapours from sodium nitrite dissolved in 2% HCl or from ‘bird soil’ containing guano droppings from swiftlet houses were able to turn white edible bird’s nests red. The reddening agent in ‘bird soil’ was water-soluble and heat-stable. The red colour of edible bird’s nests is likely caused by the environmental factors in cave interiors and swiftlet houses.
To fold or not to fold? It is shown that attached sugars play a defining role in the conformations adopted by a pair of novel SAA-derived foldamers in water and that these differences are reflected in the contrasting interactions of these glycofoldamers with various biological targets. C green, O red, N blue, H gray; green oval=mannose.
- Nursing standard (Royal College of Nursing (Great Britain) : 1987)
- Published about 3 years ago
No one knew how the tradition started, but on Christmas Day it was my job as charge nurse to come in early and make bacon butties for the staff. White sliced bread, oodles of butter and Daddies sauce - all the things you are not supposed to have, which taste all the more enjoyable for it. And tea strong enough to stand up a spoon in.
The present investigation focuses on the textural properties, sensory attributes and color changes of beef frankfurter, beef ham and meat-free sausage produced by different levels of bleached tomato pomace. The texture and color profile were performed using an instrumental texture analyzer and colorimeter. The findings indicated that tomato pomace-added sausages had higher water holding capacity (WHC) compared to that of commercial samples. The frankfurters containing 5 and 7% (w/w) tomato pomace had the highest redness (a*), chroma (C*) and color differences (ΔE) values, while the meat-free sausages containing 7% (w/w) tomato pomace had significant (p<0.05) values for lightness (L*) and yellowness (b*). Furthermore, there were no significant (p>0.05) color differences between beef ham samples (with and without tomato pomace). A significant progression in the textural hardness and chewiness of systems containing tomato pomace was observed as well as higher sensory scores by panelists. According to sensorial evaluations, bleached tomato pomace improved the consumer acceptability and preference.
Oil-soluble rosemary extract (OR) and butylated hydroxytoluene (BHT) were added individually and in mixture (MIX) to raw turkey meatballs. After cooking and chilling, samples were air- and vacuum-packaged and frozen stored for 90 days. The synthetic antioxidant, the natural antioxidant and their mixture significantly decreased TBA values. Lipid oxidation was most effectively inhibited by a mixture of BHT and OR during storage in the air, and by BHT in vacuum-packaged samples. A lower rate of the hydrolytic process was observed in BHT samples. All additives stabilized the red colour of turkey meatballs, but samples with a mixture of natural and synthetic antioxidants showed higher a(∗) values than OR samples. Vacuum-packaged turkey meatballs were darker in colour, and the contribution of redness in these samples continued to increase until day 80. OR added alone or in combination with BHT maintained the quality of turkey meatballs during frozen storage, but samples with the synthetic antioxidant were characterized by a non-typical flavour after a longer time of storage.
- Journal of physics. Condensed matter : an Institute of Physics journal
- Published about 4 years ago
The hybrid material copper (II) tetrachloro-bis(phenyl ethyl ammonium) (C6H5CH2CH2NH3)2CuCl4, or PEACuCl, has been investigated by temperature-dependent spectroscopic absorption experiments. The absorption bands observed in the near-infrared region (1.3-1.9 eV) generally exhibit redshifts with increasing temperature. The temperature-induced energy shifts of the spectral components are shown to be consistently related to temperature-induced Cu-Cl bond length changes. Additionally, the thermochromic color change is caused by a charge transfer band edge redshifting (in the visible region 2.0-2.8 eV) with increasing temperature. By comparison with similar Cu-based systems, it is suggested that this shift is caused by broadening and strengthening of the band.