SciCombinator

Discover the most talked about and latest scientific content & concepts.

Concept: Number names

158

Scientific literature can contain errors. Discrepancies, defined as two or more statements or results that cannot both be true, may be a signal of problems with a trial report. In this study, we report how many discrepancies are detected by a large panel of readers examining a trial report containing a large number of discrepancies.

Concepts: Clinical trial, ClinicalTrials.gov, Evaluation methods, Science, Number names

157

The differentiation of oncocytoma from renal cell carcinoma (RCC) remains a challenge with currently available cross-sectional imaging techniques. As a result, a large number of patients harboring a benign oncocytoma undergo unnecessary surgical resection. In this study, we explored the utility of Tc-MIBI SPECT/CT for the differentiation of these tumors based on the hypothesis that the large number of mitochondria in oncocytomas would lead to increased Tc-MIBI uptake.

Concepts: DNA, Types of cancer, Renal cell carcinoma, Number names

150

Methods for the integrative analysis of multi-omics data are required to draw a more complete and accurate picture of the dynamics of molecular systems. The complexity of biological systems, the technological limits, the large number of biological variables and the relatively low number of biological samples make the analysis of multi-omics datasets a non-trivial problem.

Concepts: Molecular biology, Mathematics, Calculus, Set theory, Logic, Computational complexity theory, Systems biology, Number names

43

New developments in genetics, anthropology, and neurobiology predict that a very large number of genes underlie our intellectual and emotional abilities, making these abilities genetically surprisingly fragile.

Concepts: DNA, Gene, Genetics, Biology, Horizontal gene transfer, Number names, Names of large numbers, Googolplex

29

To evaluate the diagnostic value of a novel fully automated immunohistochemistry (IHC) assay for detection of anaplastic lymphoma kinase (ALK) fusion in a large number of ALK-positive lung adenocarcinoma (ADC) patients.

Concepts: Adenocarcinoma, Anaplastic large cell lymphoma, Number names, Anaplastic lymphoma kinase

26

It has been proposed that the ability of humans to quickly perceive numerosity involves a visual sense of number. Different paradigms of enumeration and numerosity comparison have produced a gamut of behavioral and neuroimaging data, but there has been no unified conceptual framework that can explain results across the entire range of numerosity. The current work tries to address the ongoing debate concerning whether the same mechanism operates for enumeration of small and large numbers, through a computational approach. We describe the workings of a single-layered, fully connected network characterized by self-excitation and recurrent inhibition that operates at both subitizing and estimation ranges. We show that such a network can account for classic numerical cognition effects (the distance effect, Fechner’s law, Weber fraction for numerosity comparison) through the network steady state activation response across different recurrent inhibition values. The model also accounts for fMRI data previously reported for different enumeration related tasks. The model also allows us to generate an estimate of the pattern of reaction times in enumeration tasks. Overall, these findings suggest that a single network architecture can account for both small and large number processing.

Concepts: Mathematics, Neuroscience, Cognitive science, Perception, Number, Number names, Weber–Fechner law, Gustav Fechner

25

Rather than being polygenic, complex disorders probably represent umbrella terms for collections of conditions caused by rare, recent mutations in any of a large number of different genes.

Concepts: Gene, Genetics, Number names

24

Warts and molluscum contagiosum are very common viral skin infections, usually presenting in childhood. Despite the large number of people affected by them, high-quality trials of treatment are few and treatment is often chosen on the basis of cost, convenience and tradition.

Concepts: Infectious disease, Molluscum contagiosum, Number names, Wart, Virus-related cutaneous conditions, Cantharidin

22

Traffic noise affects a large number of people especially in urbanized areas. Noise causes stress and annoyance, but less is known about the relationship between noise and depression.

Concepts: Number names

21

Heart failure is a common, costly, and debilitating syndrome that is associated with a highly complex drug regimen, a large number of comorbidities, and a large and often disparate number of healthcare providers. All of these factors conspire to increase the risk of heart failure exacerbation by direct myocardial toxicity, drug-drug interactions, or both. This scientific statement is designed to serve as a comprehensive and accessible source of drugs that may cause or exacerbate heart failure to assist healthcare providers in improving the quality of care for these patients.

Concepts: Health care provider, Pharmacology, Mathematics, Drug, Illness, Irritation, Number names, American Heart Association