Discover the most talked about and latest scientific content & concepts.

Concept: Ming Dynasty


Cold Syndrome and Hot Syndrome are thousand-year-old key therapeutic concepts in traditional Chinese medicine (TCM), which depict the loss of body homeostasis. However, the scientific basis of TCM Syndrome remains unclear due to limitations of current reductionist approaches. Here, we established a network balance model to evaluate the imbalanced network underlying TCM Syndrome and find potential biomarkers. By implementing this approach and investigating a group of chronic superficial gastritis (CSG) and chronic atrophic gastritis (CAG) patients, we found that with leptin as a biomarker, Cold Syndrome patients experience low levels of energy metabolism, while the CCL2/MCP1 biomarker indicated that immune regulation is intensified in Hot Syndrome patients. Such a metabolism-immune imbalanced network is consistent during the course from CSG to CAG. This work provides a new way to understand TCM Syndrome scientifically, which in turn benefits the personalized medicine in terms of the ancient medicine and complex biological systems.

Concepts: Medicine, Metabolism, Acupuncture, Ming Dynasty, Traditional Chinese characters, Qi, Pernicious anemia, Atrophic gastritis


The rhizome of Polygonum cuspidatum SIEB. et ZUCC. (Polygonaceae, PC), a widely used Chinese medicine, is commonly prescribed for the treatments of amenorrhea, arthralgia, jaundice, abscess, scald and bruises.

Concepts: Pharmacology, Resveratrol, Ming Dynasty, Fallopia, Polygonaceae, Tang Dynasty


To observe the influence of therapy with Chinese medicine Lirukang Granule (, LRKG) combined with psychological intervention on anxiety states and sex hormones in patients with cyclomastopathy and menoxenia.

Concepts: Evolution, Randomized controlled trial, Human sexuality, Han Dynasty, Ming Dynasty, Tang Dynasty, Song Dynasty, Yellow Emperor


Rhubarb is a well-known traditional Chinese medicine and has been used in China for thousands of years. Anthraquinone derivatives including rhein, emodin, aloe-emodin, chrysophanol and physcion are the important components in rhubarb.

Concepts: Acupuncture, Han Dynasty, Anthraquinone, Ming Dynasty, Rhubarb, Anthraquinones, Tang Dynasty, Song Dynasty



Traditional Chinese medicine Yifei Tongluo Granules has been employed clinically with the combination of chemotherapy agents to treat patients with multidrug-resistant tuberculosis. However, the mechanisms underlying the therapeutic potential have not been well elucidated. The present study was employed to verify immunomodulatory effect and to investigate the underlying mechanisms which have not been explored.

Concepts: Chemotherapy, Han Dynasty, Traditional Chinese medicine, Ming Dynasty, Traditional Chinese characters, Tang Dynasty, Song Dynasty, Yellow Emperor


Leaf of Alstonia scholaris (L.) R. Br. (Apocynaceae), a wide used ethic-medicine in many Asia and Africa counties, has also been recorded as the common traditional Chinese medicine for treatment of illnesses in respiratory system by Dai people.

Concepts: Han Dynasty, Overseas Chinese, Ming Dynasty, Traditional Chinese characters, Tang Dynasty, Yellow Emperor, Alstonia, Alstonia scholaris


Treatment of diabetes mellitus with Traditional Chinese Medicine has a long history. The aim of this study is to establish the safety and efficacy of traditional Chinese medicine combined with glibenclamide to treat type 2 diabetes mellitus.

Concepts: Diabetes mellitus type 2, Diabetes mellitus, The Canon of Medicine, Randomized controlled trial, Sulfonylurea, Ming Dynasty, Traditional Chinese characters, Tang Dynasty


Neck pain (NP) and low back pain (LBP) are common symptoms bothering people in daily life. Traditional Chinese medicine (TCM) has been used to treat various symptoms and diseases in China and has been demonstrated to be effective. The objective of the present study was to review and analyze the existing data about pain and disability in TCM treatments for NP and LBP.

Concepts: Symptoms, Acupuncture, Han Dynasty, Overseas Chinese, Ming Dynasty, Traditional Chinese characters, Tang Dynasty, Song Dynasty


Current pain management is limited, in particular, with regard to chronic pain. In an attempt to discover novel analgesics, we combined the approach developed to characterize traditional Chinese medicine (TCM), as part of the “herbalome” project, with the reverse pharmacology approach aimed at discovering new endogenous transmitters and hormones.

Concepts: Medicine, Pain, Acupuncture, Han Dynasty, Ming Dynasty, Traditional Chinese characters, Tang Dynasty, Yellow Emperor