Discover the most talked about and latest scientific content & concepts.

Concept: Meta-analysis


 To examine the traditional diet-heart hypothesis through recovery and analysis of previously unpublished data from the Minnesota Coronary Experiment (MCE) and to put findings in the context of existing diet-heart randomized controlled trials through a systematic review and meta-analysis.

Concepts: Experimental design, Epidemiology, Evidence-based medicine, Systematic review, Randomized controlled trial, Evaluation methods, Hypothesis, Meta-analysis


Historically, alcohol use and related harms are more prevalent in men than in women. However, emerging evidence suggests the epidemiology of alcohol use is changing in younger cohorts. The current study aimed to systematically summarise published literature on birth cohort changes in male-to-female ratios in indicators of alcohol use and related harms.

Concepts: Epidemiology, Randomized controlled trial, Gender, Meta-analysis, The Current



A focus on novel, confirmatory, and statistically significant results leads to substantial bias in the scientific literature. One type of bias, known as “p-hacking,” occurs when researchers collect or select data or statistical analyses until nonsignificant results become significant. Here, we use text-mining to demonstrate that p-hacking is widespread throughout science. We then illustrate how one can test for p-hacking when performing a meta-analysis and show that, while p-hacking is probably common, its effect seems to be weak relative to the real effect sizes being measured. This result suggests that p-hacking probably does not drastically alter scientific consensuses drawn from meta-analyses.

Concepts: Scientific method, Statistics, Mathematics, Statistical significance, Science, Effect size, Meta-analysis, Statistical power


The effects of probiotic supplementation on fecal microbiota composition in healthy adults have not been well established. We aimed to provide a systematic review of the potential evidence for an effect of probiotic supplementation on the composition of human fecal microbiota as assessed by high-throughput molecular approaches in randomized controlled trials (RCTs) of healthy adults.

Concepts: Epidemiology, Gut flora, Evidence-based medicine, Systematic review, Randomized controlled trial, Effectiveness, Pharmaceutical industry, Meta-analysis


Whether light-to-moderate alcohol consumption is protective against stroke, and whether any association differs by stroke type, is controversial. We conducted a meta-analysis to summarize the evidence from prospective studies on alcohol drinking and stroke types.

Concepts: Evidence-based medicine, Systematic review, Meta-analysis, Drinking culture, Type, Seventh-day Adventist Church



Previous meta-analyses comparing the efficacy of psychotherapeutic interventions for depression were clouded by a limited number of within-study treatment comparisons. This study used network meta-analysis, a novel methodological approach that integrates direct and indirect evidence from randomised controlled studies, to re-examine the comparative efficacy of seven psychotherapeutic interventions for adult depression.

Concepts: Comparison, Evidence-based medicine, Systematic review, Randomized controlled trial, Meta-analysis, Publication bias, Cultural studies, Direct examination


To review the evidence for the short term association between air pollution and stroke.

Concepts: Evidence-based medicine, Systematic review, Meta-analysis, Term, Finance


 To determine whether feeding infants with hydrolysed formula reduces their risk of allergic or autoimmune disease.

Concepts: Systematic review, Autoimmune disease, Meta-analysis