Autism spectrum disorder (ASD) is defined by standardized criteria of qualitative impairments in social interaction, qualitative impairments in communication, and restricted and stereotyped patterns of behavior, interests, and activities. A significant number of children diagnosed with ASD suffer a loss of previously-acquired skills, which is suggestive of neurodegeneration or a type of progressive encephalopathy with an etiological pathogenic basis occurring after birth. To date, the etiology of ASD remains under debate, however, many studies suggest toxicity, especially from mercury (Hg), in individuals diagnosed with an ASD. The present study evaluated concerns about the toxic effects of organic-Hg exposure from Thimerosal (49.55% Hg by weight) in childhood vaccines by conducting a two-phased (hypothesis generating/hypothesis testing) study with documented exposure to varying levels of Thimerosal from vaccinations.
Public trust in immunization is an increasingly important global health issue. Losses in confidence in vaccines and immunization programmes can lead to vaccine reluctance and refusal, risking disease outbreaks and challenging immunization goals in high- and low-income settings. National and international immunization stakeholders have called for better monitoring of vaccine confidence to identify emerging concerns before they evolve into vaccine confidence crises.
- Journal of preventive medicine and public health = Yebang Ŭihakhoe chi
- Published about 5 years ago
Mercury is a toxic and non-essential metal in the human body. Mercury is ubiquitously distributed in the environment, present in natural products, and exists extensively in items encountered in daily life. There are three forms of mercury, i.e., elemental (or metallic) mercury, inorganic mercury compounds, and organic mercury compounds. This review examines the toxicity of elemental mercury and inorganic mercury compounds. Inorganic mercury compounds are water soluble with a bioavailability of 7% to 15% after ingestion; they are also irritants and cause gastrointestinal symptoms. Upon entering the body, inorganic mercury compounds are accumulated mainly in the kidneys and produce kidney damage. In contrast, human exposure to elemental mercury is mainly by inhalation, followed by rapid absorption and distribution in all major organs. Elemental mercury from ingestion is poorly absorbed with a bioavailability of less than 0.01%. The primary target organs of elemental mercury are the brain and kidney. Elemental mercury is lipid soluble and can cross the blood-brain barrier, while inorganic mercury compounds are not lipid soluble, rendering them unable to cross the blood-brain barrier. Elemental mercury may also enter the brain from the nasal cavity through the olfactory pathway. The blood mercury is a useful biomarker after short-term and high-level exposure, whereas the urine mercury is the ideal biomarker for long-term exposure to both elemental and inorganic mercury, and also as a good indicator of body burden. This review discusses the common sources of mercury exposure, skin lightening products containing mercury and mercury release from dental amalgam filling, two issues that happen in daily life, bear significant public health importance, and yet undergo extensive debate on their safety.
One aim of modern astronomy is to detect temperate, Earth-like exoplanets that are well suited for atmospheric characterization. Recently, three Earth-sized planets were detected that transit (that is, pass in front of) a star with a mass just eight per cent that of the Sun, located 12 parsecs away. The transiting configuration of these planets, combined with the Jupiter-like size of their host star-named TRAPPIST-1-makes possible in-depth studies of their atmospheric properties with present-day and future astronomical facilities. Here we report the results of a photometric monitoring campaign of that star from the ground and space. Our observations reveal that at least seven planets with sizes and masses similar to those of Earth revolve around TRAPPIST-1. The six inner planets form a near-resonant chain, such that their orbital periods (1.51, 2.42, 4.04, 6.06, 9.1 and 12.35 days) are near-ratios of small integers. This architecture suggests that the planets formed farther from the star and migrated inwards. Moreover, the seven planets have equilibrium temperatures low enough to make possible the presence of liquid water on their surfaces.
- International journal of occupational medicine and environmental health
- Published 11 months ago
To investigate 4 loci of 3 HSP70 genes in caustic soda production plant former workers, who have been exposed to metallic mercury vapors for a long time, and including numerous cases of chronic mercury intoxication (CMI).
The quest for Earth-like planets is a major focus of current exoplanet research. Although planets that are Earth-sized and smaller have been detected, these planets reside in orbits that are too close to their host star to allow liquid water on their surfaces. We present the detection of Kepler-186f, a 1.11 ± 0.14 Earth-radius planet that is the outermost of five planets, all roughly Earth-sized, that transit a 0.47 ± 0.05 solar-radius star. The intensity and spectrum of the star’s radiation place Kepler-186f in the stellar habitable zone, implying that if Kepler-186f has an Earth-like atmosphere and water at its surface, then some of this water is likely to be in liquid form.
As lower-mass stars often host multiple rocky planets, gravitational interactions among planets can have significant effects on climate and habitability over long timescales. Here we explore a specific case, Kepler-62f (Borucki et al., 2013 ), a potentially habitable planet in a five-planet system with a K2V host star. N-body integrations reveal the stable range of initial eccentricities for Kepler-62f is 0.00 ≤ e ≤ 0.32, absent the effect of additional, undetected planets. We simulate the tidal evolution of Kepler-62f in this range and find that, for certain assumptions, the planet can be locked in a synchronous rotation state. Simulations using the 3-D Laboratoire de Météorologie Dynamique (LMD) Generic global climate model (GCM) indicate that the surface habitability of this planet is sensitive to orbital configuration. With 3 bar of CO2 in its atmosphere, we find that Kepler-62f would only be warm enough for surface liquid water at the upper limit of this eccentricity range, providing it has a high planetary obliquity (between 60° and 90°). A climate similar to that of modern-day Earth is possible for the entire range of stable eccentricities if atmospheric CO2 is increased to 5 bar levels. In a low-CO2 case (Earth-like levels), simulations with version 4 of the Community Climate System Model (CCSM4) GCM and LMD Generic GCM indicate that increases in planetary obliquity and orbital eccentricity coupled with an orbital configuration that places the summer solstice at or near pericenter permit regions of the planet with above-freezing surface temperatures. This may melt ice sheets formed during colder seasons. If Kepler-62f is synchronously rotating and has an ocean, CO2 levels above 3 bar would be required to distribute enough heat to the nightside of the planet to avoid atmospheric freeze-out and permit a large enough region of open water at the planet’s substellar point to remain stable. Overall, we find multiple plausible combinations of orbital and atmospheric properties that permit surface liquid water on Kepler-62f. Key Words: Extrasolar planets-Habitability-Planetary environments. Astrobiology 16, xxx-xxx.
The provenance of water and organic compounds on the Earth and other terrestrial planets has been discussed for a long time without reaching a consensus. One of the best means to distinguish between different scenarios is by determining the D/H ratios in the reservoirs for comets and the Earth’s oceans. Here we report the direct in situ measurement of the D/H ratio in the Jupiter family comet 67P/Churyumov-Gerasimenko by the ROSINA mass spectrometer aboard ESA’s Rosetta spacecraft, which is found to be (5.3 ± 0.7) × 10(-4), that is, ~3 times the terrestrial value. Previous cometary measurements and our new finding suggest a wide range of D/H ratios in the water within Jupiter family objects and preclude the idea that this reservoir is solely composed of Earth ocean-like water.
None of the approximately 750,000 known asteroids and comets is thought to have originated outside our Solar System, but formation models suggest that orbital migration of the giant planets ejected a large fraction of the original planetesimals into interstellar space(1). The predicted interstellar number density(2) of icy interstellar objects of 2.4 × 10(-4) au(-3) suggested that these should have been detected by surveys, yet hitherto none had been seen. Many decades of asteroid and comet characterization have yielded formation models that explain the mass distribution, chemical abundances and planetary configuration of today’s Solar System, but until now there has been no way to tell if our Solar System is typical. Here we report observations and subsequent analysis of 1I/2017 U1 (‘Oumuamua) that demonstrate the extrasolar trajectory of 'Oumuamua. Our observations reveal the object to be asteroidal, with no hint of cometary activity despite an approach within 0.25 au of the Sun. Spectroscopic measurements show that the object’s surface is consistent with comets or organic-rich asteroid surfaces found in our own Solar System. Light-curve observations indicate that the object has an extreme oblong shape, with a 10:1 axis ratio and a mean radius of 102±4 m, assuming an albedo of 0.04. Very few objects in our Solar System have such an extreme light curve. The presence of 'Oumuamua suggests that previous estimates of the density of interstellar objects were pessimistically low. Imminent upgrades to contemporary asteroid survey instruments and improved data processing techniques are likely to produce more interstellar objects in the upcoming years.
M dwarf stars, which have masses less than 60 per cent that of the Sun, make up 75 per cent of the population of the stars in the Galaxy. The atmospheres of orbiting Earth-sized planets are observationally accessible via transmission spectroscopy when the planets pass in front of these stars. Statistical results suggest that the nearest transiting Earth-sized planet in the liquid-water, habitable zone of an M dwarf star is probably around 10.5 parsecs away. A temperate planet has been discovered orbiting Proxima Centauri, the closest M dwarf, but it probably does not transit and its true mass is unknown. Seven Earth-sized planets transit the very low-mass star TRAPPIST-1, which is 12 parsecs away, but their masses and, particularly, their densities are poorly constrained. Here we report observations of LHS 1140b, a planet with a radius of 1.4 Earth radii transiting a small, cool star (LHS 1140) 12 parsecs away. We measure the mass of the planet to be 6.6 times that of Earth, consistent with a rocky bulk composition. LHS 1140b receives an insolation of 0.46 times that of Earth, placing it within the liquid-water, habitable zone. With 90 per cent confidence, we place an upper limit on the orbital eccentricity of 0.29. The circular orbit is unlikely to be the result of tides and therefore was probably present at formation. Given its large surface gravity and cool insolation, the planet may have retained its atmosphere despite the greater luminosity (compared to the present-day) of its host star in its youth. Because LHS 1140 is nearby, telescopes currently under construction might be able to search for specific atmospheric gases in the future.