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Concept: Justin Timberlake


Objective: To present and evaluate the use of nasal dermoplasty for control of recurrent nasal polyps. Study design: Prospective case series. Method: The mucosa of the fovea ethmoidalis and the lamina papyracea was replaced by a split-thickness skin graft. The follow-up period ranged from 2 to 12 months. Results: Five patients underwent nasal dermoplasty for recurrent nasal polyposis. In three cases, the graft uptake was successful. Post-operatively, four patients reported they were in better condition than at the same interval after their previous operation. Recurrence of polyps was noted in all patients but not in the grafted areas. Conclusion: In this study, there was a high prevalence of successful graft uptake following nasal dermoplasty. This technique may have potential for the control of recurrent nasal polyps. Although it is demanding and time-consuming, it may reduce the need for multiple operations. Further research is justified to establish its efficacy.

Concepts: Scientific method, English-language films, Grafting, Case, Nasal polyp, Recurrence relation, Case series, Justin Timberlake


Initially identified as a cell and organ size controller, Hippo pathway turns into a hotspot for researchers. Within recent years, more and more mechanisms about Hippo pathway were uncovered. Even though Hippo signaling has been revealed to exert controversial roles according to different cell context and microenvironment, which is because of its diversified interplays with a great variety of signaling transduction cascades; mechanisms other than size-limitation, however, remain to be elucidated. Recently, a growing number of studies tend to put Hippo on inflammatory and immunological focus: its antimicrobial role in flies, its pro- or anti-inflammation in mammals, as well as its relevance to cancerous immunity. From inflammation to tumor immunogenicity, Hippo has been gradually justified to play a crucial role. This review summarized the latest findings regarding the involvement of Hippo pathway in immunity, and a more comprehensive understanding of Hippo pathway will shed light on clinical translational potential even precision medicine.

Concepts: Immune system, Medicine, Cancer, Oncology, Immunology, Immunity, Role, Justin Timberlake


This work demonstrates a robust diffusion-weighted single-shot FSE sequence in the presence of significant offresonance, which includes a variable-density acquisition and a self-calibrated reconstruction as improvements. An nCPMG SSFSE acquisition stabilizes both the main and parasitic echo families for each echo. This preserves both the in-phase and quadrature component of the magnetization throughout the echo train. However, nCPMG SS-FSE also promotes aliasing of the quadrature component, which complicates reconstruction. A new acquisition and reconstruction approach is presented here where the FOV is effectively doubled, but a partial k-space and variable density sampling is used to improve scan efficiency. The technique is presented in phantom scans to validate SNR and robustness against rapidly varying object phase. In vivo healthy volunteer examples and clinical cases are demonstrated in abdominal imaging. This new approach provides comparable SNR to previous nCPMG acquisition techniques as well as providing more uniform ADC maps in phantom scans. In vivo scans suggest that this method is more robust against motion than previous approaches. The proposed reconstruction is an improvement to the nCPMG sequence as it is auto-calibrating and is justified to accurately treat the signal model for the nCPMG SS-FSE sequence.

Concepts: Better, Improve, Signal processing, Demonstration, Unified Modeling Language, Object-oriented programming, Failure assessment, Justin Timberlake


Multiple landmarks including the transepicondylar axis (TEA), posterior condylar axis (PCA) and anterior trochlear line (TL) have been used to set up the femoral component rotation, but each is faced with its own practical obstacle that limits its usage. Also a common practice is to set the femoral component rotation at 3° external rotation to PCA and valgus resection angle at 5°-7° to anatomical axis of femur. For the reason that the anatomy of each knee is different, it may not be justified to practice such a set protocol in all cases. The aim of the study was to compare the anatomical landmarks used to set up the femoral component rotation and to study the variability in the different anatomical relationships relevant to total knee replacement.

Concepts: Biology, Femur, Vector space, Orthopedic surgery, Anatomy, Anatomical terms of location, Knee replacement, Justin Timberlake


Transcatheter aortic valve implantation underwent progressive improvements until it became the default therapy for inoperable patients, and a recommended therapy in high-risk operable patients with symptomatic severe aortic stenosis. In the lower-risk patient strata, a currently costly therapy that still has important complications with questionable durability is competing with the established effective and still-improving surgical replacement. This report tries to weigh the clinical evidence, the recent technical improvements, the durability, and the cost-effectiveness claims supporting the adoption of transcatheter aortic valve implantation in intermediate-low risk patients. The importance of appropriate patients' risk stratification and a more comprehensive approach to estimate that risk are also emphasized in the present report.

Concepts: Present, Clinical trial, Patient, Hospital, Physician, Aortic valve, Aortic valve stenosis, Justin Timberlake


Determination of mercury is important in the case of pharmaceuticals for which the European Union regulations have not defined the maximum permissible concentration of this metal. The aim of the study was to determine the levels of mercury in the following groups of drugs (n=119): analgesics, diuretics, cardiacs, antihypertensives, anti-influenza, antibiotics, anti-allergics, tranquilizers, antibacterials and in dietary supplements (n=33) available on the Polish market. Mercury was analyzed using cold vapor atomic fluorescence spectrometry CV-AFS. Its content in the samples varied in the range of 0.9 - 476.1 ng∙g(-1). Higher mercury concentrations were reported for prescription drugs (Rx): 0.9 - 476.1 ng∙g(-1) (median: 7.4 ng∙g(-1)), lower - for non-prescription medicines (OTC): 1.2 - 45.8 ng∙g(-1) (median: 6.0 ng∙g(-1)). In the analyzed dietary supplements the concentrations were: 0.9 - 16.7 ng∙g(-1) (median: 5.9 ng∙g(-1)). On the basis of the information contained in the leaflet accompanying the medicine, a daily dose of mercury taken into the body with an analyzed medicament was estimated and the health risk posed by using such medicines was assessed. The study indicates that it is justified to carry out measurements of mercury in pharmaceuticals due to its high, potentially harmful.

Concepts: Pharmacology, Medicine, European Union, Drug, Pharmaceutical drug, Pharmacy, Food and Drug Administration, Justin Timberlake


This report reviews the existing literature on the emergence and prevalence of speech sound errors in older children and adults. Findings from several different sources suggest that 1 to 2% of the young adult population overall may present with these errors. Up to 75% of these errors may resolve on their own between the end of the developmental period (i.e., age 9 years) and the end of high school, though speech therapy services may still be justified to reduce any negative social consequences of these errors. At least two different sources of these errors are postulated. Residual speech errors (the more common of the two types) appear to arise as a leftovers from a much earlier speech delay and were originally omission or substitution errors but migrated closer to normal to become distortions. Persistent speech errors, on the other hand, appear to be distortions from an early age that reflect long-instantiated habits. Whether this distinction points to different responses to particular interventions, or whether either type is more or less likely to resolve spontaneously is not clear at this time.

Concepts: Time, 2002 albums, Adolescence, High school, Normal distribution, Adult, Type, Justin Timberlake


Current clinical practice is to evaluate children presenting with premature adrenarche (PA) for non-classical congenital adrenal hyperplasia (NC-CAH). Our main objective was to assess the prevalence of NC-CAH among children presented with PA. Additional objectives were to ascertain whether subpopulations were prone to NC-CAH, and therefore justified to be tested, and if obesity is a factor that can exclude the need for CAH testing.

Concepts: Hirsutism, Mineralocorticoid, Congenital adrenal hyperplasia, Congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency, Adrenarche, Adrenal insufficiency, Pubarche, Justin Timberlake


The introduction of transcatheter aortic valve implantation (TAVI) has revolutionised the treatment of patients with symptomatic severe aortic valve stenosis (AS). In extreme and high-risk patients, randomised studies have shown the benefit of this new therapy. However, there are still a lot of unknowns, and the question has arisen whether it is justified to expand the indication of TAVI to other patient groups, especially intermediate-or even low-risk patients.

Concepts: Medical terms, Patient, Hospital, Physician, Introduction, Aortic valve, Aortic valve stenosis, Justin Timberlake


Background: Guidelines encourage early arteriovenous (AV) fistula (AVF) planning for haemodialysis (HD). The aim of this study was to estimate the likelihood of sustained AV access use taking into account age, sex, comorbidity, anatomical site of first AVF and, for pre-dialysis patients, eGFR and proteinuria. Methods: 1,092 patients attending our centre who had AVF as their first AV access procedure between January 1, 2000 and August 23, 2012 were identified from the electronic patient record. The primary end-point was time to first sustained AV access use, defined as use of any AV access for a minimum of 30 consecutive HD sessions. Results: 52.9% (n = 578) of the patients ultimately achieved sustained AV access use. The main reasons for AV access non-use were AVF failure to mature and death. The 3-year Kaplan-Meier probability of sustained AV access use was 68.8% for those not on renal replacement therapy (RRT) (n = 688) and 74.2% for those already on RRT (n = 404) at the time of first AVF. By multivariate analysis in patients not on RRT, male sex (HR 2.22; p < 0.001), uPCR (HR 1.03; p = 0.03) and eGFR (hazard ratio, HR 0.85; p < 0.001) were independent predictors of AV access use. In patients already on RRT, age (HR 0.98; p < 0.001) and peripheral vascular disease (HR 0.48; p = 0.02) were independent predictors of AV access use. Conclusion: Our data suggest that refinement of the current guideline for timing of AV access creation in planning RRT is justified to take into account individual factors that contribute to the likelihood of technical success and clinical need. © 2014 S. Karger AG, Basel.

Concepts: Male, Hemodialysis, Peripheral vascular disease, Multivariate statistics, Justin Timberlake