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Concept: Gastrointestinal bleeding


Upper gastrointestinal (GI) bleeding is one of the most common, high risk emergency disorders in the western world. Almost nothing has been reported on longer term prognosis following upper GI bleeding. The aim of this study was to establish mortality up to three years following hospital admission with upper GI bleeding and its relationship with aetiology, co-morbidities and socio-demographic factors.

Concepts: Central Europe, Western Europe, Surgery, Western culture, Gastrointestinal bleeding, Western world, Gastroenterology, Upper gastrointestinal bleeding


To investigate the clinical impact of capsule endoscopy (CE) after an obscure gastrointestinal bleeding (OGIB) episode, focusing on diagnostic work-up, follow-up and predictive factors of rebleeding.

Concepts: Colonoscopy, Gastrointestinal bleeding, Endoscopy, Gastroenterology


Aspirin has been shown to lower the incidence and the mortality of vascular disease and cancer but its wider adoption appears to be seriously impeded by concerns about gastrointestinal (GI) bleeding. Unlike heart attacks, stroke and cancer, GI bleeding is an acute event, usually followed by complete recovery. We propose therefore that a more appropriate evaluation of the risk-benefit balance would be based on fatal adverse events, rather than on the incidence of bleeding. We therefore present a literature search and meta-analysis to ascertain fatal events attributable to low-dose aspirin.

Concepts: Systematic review, Aspirin, Gastroenterology, Gastrointestinal bleeding, Medical statistics, Stroke, Randomized controlled trial, Epidemiology


Patients on antithrombotic therapy (ATT) have the highest risk of ongoing bleeding and mortality. Hemospray (Cook Medical, Winston-Salem, North Carolina, USA) is a novel hemostatic agent for the treatment of upper gastrointestinal bleeding (UGIB). Initial reports on its use appear promising in terms of initial hemostasis and rebleeding rates. It is unknown whether this also pertains to patients on ATT. The aim of the current study therefore was to evaluate the efficacy of Hemospray in the treatment of UGIB in patients taking ATTs. A total of 16 unselected consecutive patients with UGIB who were treated with Hemospray were analyzed (eight taking ATT for various indications and eight not on ATT). Initial hemostasis was achieved after Hemospray application in 5 /8 patients on ATT (63 %) and in all eight patients not on therapy (P = 0.20). Rebleeding rates were similar in both groups. These preliminary data on the use of Hemospray in the management of UGIB are promising in both patients with and without ATT; however, caution should be exercised for its use in patients on ATT with spurting arterial bleeding.

Concepts: North Carolina, Gastrointestinal bleeding, Antihemorrhagic, Bleeding, Medical emergencies, Upper gastrointestinal bleeding, Hemostasis, Gastroenterology


Therapeutic angioembolization is a relatively new “rescue treatment” modality for gastrointestinal hemorrhage (GIH) for unstable patients who fail primary treatment approaches; however, the effectiveness of this treatment and the incidence of ischemic necrosis following embolization for acute GIH are poorly described. The purpose of this study was to evaluate the effectiveness and safety of “rescue” transcatheter superselective angioembolization (SSAE) for the treatment of hemodynamically unstable patients with GIH.

Concepts: Gastroenterology, Gastrointestinal bleeding, Ischemia


To determine the accuracy of the Faecal Occult Blood-Transferrin test (FOB-T; Certest Biotec, San Mateo de Gállego, Spain) for detection of blood in nasogastric aspirate, and its emergency diagnostic value for upper gastrointestinal bleeding (UGIB).

Concepts: Lower gastrointestinal bleeding, Medical emergencies, Gastrointestinal bleeding, Blood, Diagnosis, Upper gastrointestinal bleeding, Gastroenterology


With small diameter endoscopes, transnasal esophagogastroduodenoscopy (t-EGD) is routinely performed. The aim of this prospective observational study was to evaluate the role of t-EGD for upper gastrointestinal bleeding (UGIB).

Concepts: Medical emergencies, Gastrointestinal bleeding, Endoscopy, Colonoscopy, Observational study, Gastroenterology, Upper gastrointestinal bleeding, Esophagogastroduodenoscopy


To examine the effect of supplementation with probiotics on respiratory and gastrointestinal illness in healthy active men and women.

Concepts: Gastrointestinal bleeding, Digestive system, Probiotic


Hemostatic powders have been introduced to improve the management of gastrointestinal (GI) bleeding and to extend the variety of tools available for emergency endoscopy. The aim of the present pilot study was to evaluate the indication profiles and the short-term outcome of EndoClot.

Concepts: Hemostasis, Gastrointestinal bleeding, Present, Time