Concept: Futures contract
Many choice situations require imagining potential outcomes, a capacity that was shown to involve memory brain regions such as the hippocampus. We reasoned that the quality of hippocampus-mediated simulation might therefore condition the subjective value assigned to imagined outcomes. We developed a novel paradigm to assess the impact of hippocampus structure and function on the propensity to favor imagined outcomes in the context of intertemporal choices. The ecological condition opposed immediate options presented as pictures (hence directly observable) to delayed options presented as texts (hence requiring mental stimulation). To avoid confounding simulation process with delay discounting, we compared this ecological condition to control conditions using the same temporal labels while keeping constant the presentation mode. Behavioral data showed that participants who imagined future options with greater details rated them as more likeable. Functional MRI data confirmed that hippocampus activity could account for subjects assigning higher values to simulated options. Structural MRI data suggested that grey matter density was a significant predictor of hippocampus activation, and therefore of the propensity to favor simulated options. Conversely, patients with hippocampus atrophy due to Alzheimer’s disease, but not patients with Fronto-Temporal Dementia, were less inclined to favor options that required mental simulation. We conclude that hippocampus-mediated simulation plays a critical role in providing the motivation to pursue goals that are not present to our senses.
The aim of this article is to revisit Ferenczi’s Clinical Diary (1932) to investigate the influence he had on Melanie Klein’s work. It starts from the position that insufficient recognition has been given to Ferenczi’s contribution to Klein’s body of work and her professional development. Her analysis with Ferenczi lasted 5 years, a relatively long analysis for the period. It explores his influence in three specific areas: the importance of raw and early emotion in the maternal bond, the importance of freedom and authenticity in the analytic relationship, and finally the use of transference and countertransference feelings. Ferenczi’s ill-fated experiment with mutual analysis will be discussed as it opened up a route to explore the analytic relationship, with important consequences for the future development of psychoanalysis.
The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse range of underlying dominant disease processes and pathways despite apparent similarities in clinical expression. Here, we present the current understanding of asthma pathogenesis. We discuss airway inflammation (both T2(HIGH) and T2(LOW)), airway hyperresponsiveness (AHR) and airways remodelling as four key factors in asthma pathogenesis, and also outline other contributory factors such as genetics and co-morbidities. Response to current asthma therapies also varies greatly, which is probably related to the inter-patient differences in pathogenesis. Here, we also summarize how our developing understanding of detailed pathological processes potentially translates into the targeted treatment options we require for optimal asthma management in the future.
- Canadian journal of experimental psychology = Revue canadienne de psychologie experimentale
- Published over 1 year ago
Though much research has been conducted on the causes and processes underlying mind wandering, relatively little has addressed what happens after an episode of mind wandering. We explore this issue in the context of reading. Specifically, by examining re-reading behaviours following mind wandering episodes. Results from 2 studies reveal that after mind wandering, participants re-read nearly half the time. This re-reading occurs whether mind wandering is self-caught or probe-caught, and it typically involves retracing a line or 2 of text. Based on subjective reports, it appears that individuals re-read when they feel that clarification of the text is needed, suggesting that a key concept of the text is missed during a mind wandering episode. Future work aimed at understanding how individuals refocus their attention following mind wandering in different settings should provide additional insights into the fluctuation of attentional focus and the immediate impact of a mind wandering episode. (PsycINFO Database Record
Interleukin-22 (IL-22) is involved in the development of lymphocytes and serves as a rapid and early source of the effector cytokines that are released in response to pathogen-induced changes in the microenvironment. Recent research has implicated IL-22 as a potential contributing factor to the spectrum of inflammation-related pancreatic diseases, particularly pancreatitis, fibrosis, carcinoma and diabetes. In this review, we summarize the current knowledge on the roles of IL-22 in the various pancreatic pathogenesis, providing insights into the underlying cellular and signaling mechanisms that will help guide future research into promising interventional targets with therapeutic potential.
Clear empirical demonstrations of the theoretical principles underlying assortative mating remain elusive. This article examines a moderator of assortative mating-how well couple members knew each other before dating-suggested by recent findings related to market-based (i.e., competition) theories. Specifically, competition is pervasive to the extent that people achieve consensus about who possesses desirable qualities (e.g., attractiveness) and who does not. Because consensus is stronger earlier in the acquaintance process, assortative mating based on attractiveness should be stronger among couples who formed a relationship after a short period rather than a long period of acquaintance. A study of 167 couples included measures of how long partners had known each other before dating and whether they had been friends before dating, as well as coders' ratings of physical attractiveness. As predicted, couples revealed stronger evidence of assortative mating to the extent that they knew each other for a short time and were not friends before initiating a romantic relationship.
Many young adult female cancer survivors (YAFCS) are at risk of experiencing premature menopause. The current study characterized the posttreatment fertility information needs, reproductive concerns, and decisional conflict regarding future options for posttreatment fertility preservation (FP) among YAFCS.
Systematic reviews are important for decision makers. They offer many potential benefits but are often written in technical language, are too long, and do not contain contextual details which make them hard to use for decision-making. There are many organizations that develop and disseminate derivative products, such as evidence summaries, from systematic reviews for different populations or subsets of decision makers. This systematic review aimed to (1) assess the effectiveness of evidence summaries on policymakers' use of the evidence and (2) identify the most effective summary components for increasing policymakers' use of the evidence. We present an overview of the available evidence on systematic review derivative products.
Acute kidney injury (AKI) is common and is associated with serious short- and long-term complications. Early diagnosis and identification of the underlying aetiology are essential to guide management. In this review, we outline the current definition of AKI and the potential pitfalls, and summarise the existing and future tools to investigate AKI in critically ill patients.
To investigate the role of eccentric knee flexor strength, between-limb imbalance and biceps femoris long head (BFlh) fascicle length on the risk of future hamstring strain injury (HSI).