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Concept: Frequentative


Recent research suggests that frequently switching between various forms of media (i.e. ‘media multitasking’) is associated with diminished attentional abilities, a disconcerting result given the prevalence of media multitasking in today’s society. In the present study, we sought to investigate the extent to which the deficits associated with frequent media multitasking can be temporarily ameliorated via a short-term mindfulness intervention previously shown to produce beneficial effects on the attentional abilities of normally functioning individuals. Consistent with previous work, we found: (1) that heavy media multitaskers showed generally poorer attentional abilities than light media multitaskers and (2) that all participants showed benefits from the short-term mindfulness intervention. Furthermore, we found that the benefits of the short-term mindfulness intervention were not equivalently large across participants. Instead, these benefits were disproportionately large in the heavy media multitaskers. While the positive outcomes were short-lived, this opens the possibility of performing long-term interventions with the goal of realizing lasting gains in this population.

Concepts: Present, Time, Term, Intervention, Frequentative


Early evidence suggests that provisions of the Food and Drug Administration Safety and Innovation Act of 2012 are associated with reductions in the total number of new national drug shortages. However, drugs frequently used in acute unscheduled care such as the care delivered in emergency departments may be increasingly affected by shortages. Our estimates, based on reported national drug shortages from 2001 to 2014 collected by the University of Utah’s Drug Information Service, show that although the number of new annual shortages has decreased since the act’s passage, half of all drug shortages in the study period involved acute care drugs. Shortages affecting acute care drugs became increasingly frequent and prolonged compared with non-acute care drugs (median duration of 242 versus 173 days, respectively). These results suggest that the drug supply for many acutely and critically ill patients in the United States remains vulnerable despite federal efforts.

Concepts: United States, Drug, Illness, Affect, U.S. state, Drugs, Frequentative


Long-term immunosuppressive therapy with severe adverse effects is indispensable to maintain disease remission in frequently relapsing nephrotic syndrome (NS) in children. Hence, development of new therapy with less toxicity for relapses of NS is required. We demonstrated a case of a 2-year-old boy with frequently relapsing NS, whose frequent relapses were successfully treated with azithromycin. Azithromycin treatment prevented the need for long-term immunosuppressive therapy in this case. Azithromycin could be a new treatment option for relapse of NS, with few adverse effects, in selected cases.

Concepts: Immune system, Chemotherapy, Nephrotic syndrome, Syndromes, Relapse, Case, Frequentative, Nephritic syndrome


In this study we examined associations between young adults' drinking patterns and social status within their natural drinking groups (NDGs) and assessed gender differences in these relationships. Same-sex NDGs (n=104) on route to a bar district were recruited and completed a peer-nominated measure of within-NDG status. In a follow-up online survey, participants (n=293; 174 men and 119 women) reported their usual drinking pattern within the past year. Hierarchical Linear Modeling revealed that men who engaged in more frequent heavy episodic drinking (HED) (both for 5+ and 8+ drinks in one sitting) and women who drank more frequently were nominated as occupying higher-status positions within their NDGs compared to their peers who drank less. Further, for both men and women, drinking more than one’s peers during one’s heaviest drinking occasion in the past year was also associated with higher within-NDG status. These findings suggest that higher social status is associated with riskier drinking patterns and have important implications for prevention programming.

Concepts: Gender, Sociology, Gender role, Pattern, Frequentative, Gender identity, Transgender, Social status


Immunogenicity of biopharmaceutical products in multiple sclerosis is a frequent side effect which has a multifactorial etiology. Here we study associations between anti-drug antibody (ADA) occurrence and demographic and clinical factors. Retrospective data from routine ADA test laboratories in Sweden, Denmark, Austria and Germany (Dusseldorf group) and from one research study in Germany (Munich group) were gathered to build a collaborative multi-cohort dataset within the framework of the ABIRISK project. A subset of 5638 interferon-beta (IFNβ)-treated and 3440 natalizumab-treated patients having data on at least the first two years of treatment were eligible for interval-censored time-to-event analysis. In multivariate Cox regression, IFNβ-1a subcutaneous and IFNβ-1b subcutaneous treated patients were at higher risk of ADA occurrence compared to IFNβ-1a intramuscular-treated patients (pooled HR = 6.4, 95% CI 4.9-8.4 and pooled HR = 8.7, 95% CI 6.6-11.4 respectively). Patients older than 50 years at start of IFNβ therapy developed ADA more frequently than adult patients younger than 30 (pooled HR = 1.8, 95% CI 1.4-2.3). Men developed ADA more frequently than women (pooled HR = 1.3, 95% CI 1.1-1.6). Interestingly we observed that in Sweden and Germany, patients who started IFNβ in April were at higher risk of developing ADA (HR = 1.6, 95% CI 1.1-2.4 and HR = 2.4, 95% CI 1.5-3.9 respectively). This result is not confirmed in the other cohorts and warrants further investigations. Concerning natalizumab, patients older than 45 years had a higher ADA rate (pooled HR = 1.4, 95% CI 1.0-1.8) and women developed ADA more frequently than men (pooled HR = 1.4, 95% CI 1.0-2.0). We confirmed previously reported differences in immunogenicity of the different types of IFNβ. Differences in ADA occurrence by sex and age are reported here for the first time. These findings should be further investigated taking into account other exposures and biomarkers.

Concepts: Antibody, Cohort study, Cohort, Multiple sclerosis, Frequentative, Biopharmaceutical, Natalizumab, Finnish language


The proposed research is part of ongoing operations research within World Vision’s Access: Infant and Maternal Health Programme. This study aims to identify key context features and underlying mechanisms through which community health committees build community capacity within the field of maternal and child health. This may help to improve programme implementation by providing contextually informed and explanatory findings for how community health committees work, what works best and for whom do they work for best for. Though frequently used within health programmes, little research is carried out on such committees' contribution to capacity building-a frequent goal or proposed outcome of these groups.

Concepts: Infant, Frequentative, Program, Project management, Building


Numerous studies have examined the connection between pornography viewing and marital quality, with findings most often revealing a negative association. Data limitations, however, have precluded establishing directionality with a representative sample. This study is the first to draw on nationally representative, longitudinal data (2006-2012 Portraits of American Life Study) to test whether more frequent pornography use influences marital quality later on and whether this effect is moderated by gender. In general, married persons who more frequently viewed pornography in 2006 reported significantly lower levels of marital quality in 2012, net of controls for earlier marital quality and relevant correlates. Pornography’s effect was not simply a proxy for dissatisfaction with sex life or marital decision-making in 2006. In terms of substantive influence, frequency of pornography use in 2006 was the second strongest predictor of marital quality in 2012. Interaction effects revealed, however, that the negative effect of porn use on marital quality applied to husbands, but not wives. In fact, post-estimation predicted values indicated that wives who viewed pornography more frequently reported higher marital quality than those who viewed it less frequently or not at all. The implications and limitations of this study are discussed.

Concepts: Marriage, Longitudinal study, Interaction, Sociology, Husband, Negative feedback, Frequentative, Pornography


Advising patients about when they can drive after surgery is common practice after arthroplasty of the knee or hip. In the literature, the preoperative braking performance values of the patients are frequently taken as the “safe” landmark. We hypothesised that osteoarthritis (OA), the most frequent reason for arthroplasty, already compromises the ability to perform an emergency stop. We expected that both Reaction Time (RT) and Movement Time (MT) as components of the Total Brake Response Time (TBRT), would be prolonged in patients with OA of the knee or hip in comparison with healthy subjects. We also expected maximum pressure levels on the brake pedal to be reduced in such cases.

Concepts: Cross-sectional study, Osteoarthritis, Hip replacement, Performance, Frequentative, Automobile, Brake, Breeching


The aim of this paper was to systematically review the evidence for the association between television viewing and diet in children ages 2-6. Data sources included PubMed, PsycINFO, EMBASE, ERIC, SportDISCUS, Sociological Abstracts, Web of Science and hand searches of reference lists of relevant articles. Twelve studies were reviewed in which the relationship between television viewing and diet was assessed in children between the ages of 2 and 6. All but one study reported significant relationship between television viewing time and adverse dietary outcomes. Parent-reported television viewing time was used to assay child television viewing in all included studies. Food frequency survey was the most frequent method of dietary assessment, and parent served as proxies for children in all studies. Lower fruit and/or vegetable intake was the most frequently reported dietary outcome, followed by increased energy intake with increased television viewing. The majority of studies reported adverse dietary outcomes with as little as 1 h of daily television exposure. While these results are consistent with recommendations from child health advocates to limit television viewing in young children, they also suggest that further efforts to limit television viewing in young children may be needed to aid in obesity prevention.

Concepts: Nutrition, Assessment, Child, Childhood, Diet, Frequentative, Diabetic diet, Outcome


We aimed to investigate whether the impact on families of children with Autism Spectrum Disorder (ASD) is associated with the number and/or type of emotional and behavioral co-existing conditions that parents/carers of children with ASD reported as occurring frequently. In addition, we examined whether there was a greater impact on families if their child was male, had lower levels of language, had more severe autism symptomatology, and whether impact was associated with the number and/or type of co-existing conditions. Families were recruited from large UK research databases. 420 parents/carers of children aged 3 years 2 months to 18 years 8 months completed the revised Impact on Family (IoF) Scale and reported on the frequency/rate of their child’s co-existing conditions. Parents/carers reported higher mean IoF scores if their child: had a greater number of frequent co-existing conditions; had sleep problems; was only able to communicate physically; and had more severe autism symptomatology. The development and implementation of targeted treatment and management approaches are needed to reduce the impact of co-existing conditions on family life. Autism Res 2018. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.

Concepts: Family, Autism, Pervasive developmental disorder, Child, Asperger syndrome, Autism spectrum, PDD-NOS, Frequentative