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Concept: Diphtheria


Pertussis in adults and adolescents could be reduced by replacing traditional tetanus and diphtheria (Td) boosters with reduced-antigen-content diphtheria-tetanus-acellular pertussis (dTpa) vaccines. This study evaluated the administration of dTpa-IPV (dTpa-inactivated poliovirus) in adults ten years after they received a booster dose of either dTpa-IPV, dTpa+IPV or Td-IPV in trial NCT01277705.

Concepts: Public health, Vaccine, Vaccination, Polio vaccine, Immunology, Tetanus, Pertussis, Diphtheria


In clinical trials, diphtheria, tetanus and acellular pertussis vaccines have been shown to be less reactogenic than whole-cell combination vaccines.

Concepts: Clinical trial, Vaccine,, Tetanus, Bacterial diseases, Pertussis, DPT vaccine, Diphtheria


In the United States, children receive five doses of diphtheria, tetanus, and acellular pertussis (DTaP) vaccine before 7 years of age. The duration of protection after five doses of DTaP is unknown.

Concepts: Vaccine, United States, Poverty in the United States, U.S. state, Tetanus, Pertussis, DPT vaccine, Diphtheria


 To identify and characterise non-specific immunological effects after routine childhood vaccines against BCG, measles, diphtheria, pertussis, and tetanus.

Concepts: Vaccine, Tetanus, Bacterial diseases, Pertussis, Diphtheria


Since October 2012, the combined tetanus toxoid, reduced diphtheria toxoid, acellular pertussis vaccine (Tdap) has been recommended in the United States during every pregnancy.

Concepts: Vaccine, United States, Tetanus, Tetanospasmin, Clostridium tetani, Pertussis, DPT vaccine, Diphtheria


Reduced-antigen-content tetanus, diphtheria, and acellular pertussis (Tdap) vaccine is recommended in many countries for boosting immunity in adolescents and adults. Although immunity to these antigens wanes with time, currently available Tdap products are not labeled for repeat administration in the United States.

Concepts: Immune system, Vaccine, Randomized controlled trial, United States, Tetanus, Pertussis, DPT vaccine, Diphtheria


The effectiveness of diphtheria, tetanus, and acellular pertussis (DTaP) vaccines wanes substantially after the 5(th) dose given at ages 4-6years, but has not been described following 5 doses of the same type of DTaP vaccine. We investigated waning effectiveness against pertussis in California over nearly 10years, which included large pertussis outbreaks, following 5 doses of GSK DTaP vaccines (DTaP3).

Concepts: Vaccine, Dose, Tetanus, Pertussis, Vaccines, DPT vaccine, Diphtheria, DTaP


In 2010, California experienced its largest pertussis epidemic in more than 60 years; a substantial burden of disease was noted in the 7- to 10-year-old age group despite high diphtheria, tetanus, and acellular pertussis vaccine (DTaP) coverage, indicating the possibility of waning protection.

Concepts: Infectious disease, Vaccine, Dose, Tetanus, Bacterial diseases, Pertussis, DPT vaccine, Diphtheria


Launched in 1974, the Expanded Program on Immunization (EPI) is estimated to prevent two-three million deaths annually from polio, diphtheria, tuberculosis, pertussis, measles, and tetanus. Additional lives could be saved through better understanding what influences adherence to the EPI schedule in specific settings.

Concepts: Cohort study, Infectious disease, Malaria, Vaccine, Tetanus, Bacterial diseases, Pertussis, Diphtheria


Non-toxigenic Corynebacterium diphtheriae strains are emerging as a major cause of severe pharyngitis and tonsillitis as well as invasive diseases such as endocarditis, septic arthritis, splenic abscesses and osteomyelitis. C. diphtheriae strains have been reported to vary in their ability to adhere and invade different cell lines. To identify the genetic basis of variation in the degrees of pathogenicity, we sequenced the genomes of four strains of C. diphtheriae (ISS 3319, ISS 4060, ISS 4746 and ISS 4749) that are well characterised in terms of their ability to adhere and invade mammalian cells.

Concepts: DNA, Gene, Genetics, Cell, Inflammations, Diphtheria, Corynebacterium, Corynebacterium diphtheriae