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Concept: Derivative


Politicians world-wide frequently promise a better life for their citizens. We find that the probability that a country will increase its per capita GDP (gdp) rank within a decade follows an exponential distribution with decay constant λ = 0.12. We use the Corruption Perceptions Index (CPI) and the Global Competitiveness Index (GCI) and find that the distribution of change in CPI (GCI) rank follows exponential functions with approximately the same exponent as λ, suggesting that the dynamics of gdp, CPI, and GCI may share the same origin. Using the GCI, we develop a new measure, which we call relative competitiveness, to evaluate an economy’s competitiveness relative to its gdp. For all European and EU countries during the 2008-2011 economic downturn we find that the drop in gdp in more competitve countries relative to gdp was substantially smaller than in relatively less competitive countries, which is valuable information for policymakers.

Concepts: European Union, Radioactive decay, Probability theory, Derivative, Exponential growth, Exponential function, Competitiveness, Global Competitiveness Report


SUMMARY: Pathview is a novel tool set for pathway based data integration and visualization. It maps and renders user data on relevant pathway graphs. Users only need to supply their data and specify the target pathway. Pathview automatically downloads the pathway graph data, parses the data file, maps and integrates user data onto the pathway, and renders pathway graphs with the mapped data. Although built as a stand-alone program, Pathview may seamlessly integrate with pathway and functional analysis tools for large-scale and fully automated analysis pipelines. AVAILABILITY: The package is freely available under the GPLv3 licence through Bioconductor and R-Forge. It is available at and at CONTACT:

Concepts: Mathematics, Integral, Vector space, Derivative, Functional analysis


We have conducted a population-based study of pleural mesothelioma patients with occupational histories and measured asbestos lung burdens in occupationally exposed workers and in the general population. The relationship between lung burden and risk, particularly at environmental exposure levels, will enable future mesothelioma rates in people born after 1965 who never installed asbestos to be predicted from their asbestos lung burdens.

Concepts: Cancer, Metastasis, Lung cancer, Cancer staging, Pleural effusion, Derivative, Mesothelioma, Asbestos


In 2007, the province of British Columbia implemented incentive payments to primary care physicians for the provision of comprehensive, continuous, guideline-informed care for patients with 2 or more chronic conditions. We examined the impact of this program on primary care access and continuity, rates of hospital admission and costs.

Concepts: Medicine, Hospital, Physician, Calculus, Derivative, Provinces and territories of Canada, Canada, British Columbia


This article describes a community-engaged study with the Los Angeles House and Ball scene in which the perspectives of the leaders of these communities are captured to better understand how the House and Ball communities may protect or increase its members' risks for HIV infection. Data were collected through in-depth interviews with House parents (N = 26). This study identified key features of both support (e.g., family and support, acceptance, and validation and recognition) and risk (e.g., members' struggles to maintain status in the Ballroom scene, sex work, substance use, danger of becoming too involved in the Ball community, and perception and stigma of the Ballroom scene within the larger gay community) within these communities. Findings are discussed in relation to framing how to leverage the supportive aspects of the House and Ball communities to design relevant HIV-prevention interventions.

Concepts: HIV, Infectious disease, Risk, Parent, Derivative, Community, Support, Ball culture


Legitimate opioid use is associated with an increased risk of long-term opioid use and possibly misuse in adults. The objective of this study was to estimate the risk of future opioid misuse among adolescents who have not yet graduated from high school.

Concepts: Opioid, Adolescence, High school, Derivative, Graduation, High School Musical, Arbitrage


Reoperation for failing stentless aortic valve replacement is a technically demanding procedure that has traditionally been tackled in one of two ways: either root replacement or the more conservative option of implanting a stented valve within the valve. We sought to determine the relative operative risks, follow-up status and medium to long-term survival of these two methods.

Concepts: Derivative, Left ventricle, Aortic valve, Valve, Valve Corporation, Aortic valve replacement, Aortic insufficiency


Localization microscopy relies on computationally efficient Gaussian approximations of the point spread function for the calculation of fluorophore positions. Theoretical predictions show that under specific experimental conditions, localization accuracy is significantly improved when the localization is performed using a more realistic model. Here, we show how this can be achieved by considering three-dimensional (3-D) point spread function models for the wide field microscope. We introduce a least-squares point spread function fitting framework that utilizes the Gibson and Lanni model and propose a computationally efficient way for evaluating its derivative functions. We demonstrate the usefulness of the proposed approach with algorithms for particle localization and defocus estimation, both implemented as plugins for ImageJ.

Concepts: Mathematics, Biology, Function, Microscope, Derivative, Microscopy, Continuous function, Point spread function


An approximate expression for Henry’s function, describing the electrophoretic mobility of a spherical colloidal particle in the limit of low surface potentials, is developed through a physical analogy to a colloidal particle with a linearly slipping surface (i.e. satisfies the Navier slip condition). The resulting expression reproduces Henry’s function with a relative error of no more than 0.1%. This approach is generalized for the electrophoretic mobility of a particle regardless of surface potential though necessary data for rigorous testing is lacking.

Concepts: Function, Colloid, Topology, Derivative, Numerical analysis, Potential, Colloidal chemistry, Zeta potential


With a view to development of novel sialidase inhibitors, mimetics of the natural inhibitor Neu5Ac2en have been prepared in which a phosphonate group replaces the sialic acid glycerol side chain. Different hex-4-en derivatives adopt half-chair conformations that place the glycosyl phosphonate in an equatorial position. For the α-L-threo-hex-4-en derivative this conformation is equivalent to that of Neu5Ac2en, and opposite to that seen for alkyl O-glycosides with the same overall stereochemistry.

Concepts: Tertiary structure, Stereochemistry, Calculus, Vector space, Derivative, Conformation, Conformational isomerism, Cyclohexane conformation