SciCombinator

Discover the most talked about and latest scientific content & concepts.

Concept: Corneal transplantation

169

Combination of riboflavin/UVA cross-linking (CXL) and excimer laser ablation is a promising therapy for treating corneal ectasia. The cornea is strengthened by cross-linking, while the irregular astigmatism is reduced by laser ablation. This study aims to compare the efficacy of excimer laser ablation on porcine corneas with and without cross-linking.

Concepts: Laser, Cornea, Corneal transplantation, Refractive surgery, Contact lens, LASIK, Excimer laser, Keratoconus

29

Immunologic graft rejection is one of the main causes of short and long-term graft failure in corneal transplantation. Steroids are the most commonly used immunosuppressive agents for postoperative management and prevention of corneal graft rejection. However, steroids delivered in eye drops are rapidly cleared from the surface of the eye, so the required frequency of dosing for corneal graft rejection management can be as high as once every 2h. Additionally, these eye drops are often prescribed for daily use for 1year or longer, which can result in poor patient compliance and steroid-related side effects. Here, we report a biodegradable nanoparticle system composed of Generally Regarded as Safe (GRAS) materials that can provide sustained release of corticosteroids to prevent corneal graft rejection following subconjunctival injection provided initially during transplant surgery. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing dexamethasone sodium phosphate (DSP) exhibited a size of 200nm, 8wt.% drug loading, and sustained drug release over 15days in vitro under sink conditions. DSP-loaded nanoparticles provided sustained ocular drug levels for at least 7days after subconjunctival administration in rats, and prevented corneal allograft rejection over the entire 9-week study when administered weekly. In contrast, control treatment groups that received weekly injections of either placebo nanoparticles, saline, or DSP in solution demonstrated corneal graft rejection accompanied by severe corneal edema, neovascularization and opacity that occurred in ≤4weeks. Local controlled release of corticosteroids may reduce the rate of corneal graft rejection, perhaps especially in the days immediately following surgery when risk of rejection is highest and when typical steroid eye drop administration requirements are particularly onerous.

Concepts: Immune system, Surgery, Immunology, Eye, Cornea, Organ transplant, Corneal transplantation, Transplantation medicine

28

: To report the short-term visual outcomes and complications of keratoprosthesis surgery as the primary penetrating corneal procedure for patients at high risk for conventional corneal transplantation.

Concepts: Ophthalmology, Corneal transplantation, Boston keratoprosthesis, Keratoprosthesis

27

To compare the visual outcomes and postoperative complications in patients undergoing penetrating keratoplasty (PKP) in 1 eye followed by Descemet membrane endothelial keratoplasty (DMEK) in their fellow eye.

Concepts: Comparison, Cornea, Corneal transplantation, Comparisons

27

To investigate the biomechanical and refractive behaviors of normal and keratoconic corneas based on three-dimensional anisotropic hyperelastic corneal models with two layers.

Concepts: Cornea, Corneal transplantation

26

To investigate pathomechanisms involved in graft detachment after Descemet’s membrane endothelial keratoplasty (DMEK) and its clinical implications.

Concepts: Corneal transplantation

23

Glaucoma is a well-known complication following corneal transplantation surgery. Traditional corneal transplantation surgery, specifically penetrating keratoplasty (PK), has been slowly replaced by the advent of new corneal transplantation procedures: primarily lamellar keratoplasties. There has also been an emergence of keratoprosthesis implants for eyes that are high risk of failure with PK. Consequently, there are different rates of glaucoma, pathogenesis, and potential treatment in the form of medical, laser or surgical therapy.

Concepts: Medicine, Surgery, Laser, Ophthalmology, Corneal transplantation, Boston keratoprosthesis

23

To report the failure rate of 2 graft preparation techniques for Descemet membrane endothelial keratoplasty (DMEK) and to evaluate how to minimize graft preparation failure.

Concepts: Corneal transplantation, Failure, Failure rate, Reliability engineering

23

To report a case of interface fluid syndrome after LASIK in a patient with Fuchs' corneal endothelial dystrophy treated with Descemet membrane endothelial keratoplasty (DMEK).

Concepts: Cornea, Ophthalmology, Corneal transplantation, Fuchs' dystrophy, Descemet's membrane

23

To analyze the incidence and clinical course of graft rejection episodes after Descemet membrane endothelial keratoplasty (DMEK).

Concepts: Immune system, Cornea, Corneal transplantation