Discover the most talked about and latest scientific content & concepts.

Concept: Carotid artery dissection


There are no reliable data from randomised trials to decide whether anticoagulants or antiplatelet agents are better to prevent further thromboembolic events after cervical arterial dissection. Most neurologists favour anticoagulants based on the underlying pathology and the likely course of acute post-dissection thromboembolism.

Concepts: Thrombosis, Antiplatelet drug, Vertebral artery dissection, Coronary artery dissection, Carotid artery dissection


Cervical artery dissection (CAD) and stroke are serious harms that are sometimes associated with cervical spinal manipulation therapy (cSMT). Because of the relative rarity of these adverse events, studying them prospectively is challenging. As a result, systematic review of reports describing these events offers an important opportunity to better understand the relation between adverse events and cSMT. Of note, the quality of the case report literature in this area has not yet been assessed.

Concepts: Myocardial infarction, Atherosclerosis, Blood pressure, Galen, Vertebral artery dissection, Coronary artery dissection, Pseudoaneurysm, Carotid artery dissection


For patients and health care providers who are considering spinal manipulative therapy of the neck, it is crucial to establish if it is a trigger for cervical artery dissection and/or stroke, and if it is, the magnitude of the risk.

Concepts: Health care, Health care provider, Medicine, Vertebral column, Vertebral artery dissection, Joint manipulation, Subclavian artery, Carotid artery dissection



Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS).

Concepts: Observational study, Stroke, Transient ischemic attack, Vertebral artery dissection, Carotid artery dissection


Cervical arterial dissection (CAD) is a common cause of stroke in young people under 55 years. It can occur spontaneously or subsequent to minor trauma or infection. The incidence is difficult to determine accurately as not all CAD progress to stroke. CAD is the most catastrophic adverse event associated with cervical manipulative therapy but it is rare. Early features of CAD can mimic a painful musculoskeletal presentation and a patient may present for treatment of neck pain and headache with a dissection in progress. Whether the manipulative technique is responsible for dissection or whether the diagnosis of CAD has been missed is unclear. Identification of individuals at risk, or early recognition of CAD could help expedite medical intervention and avoid inappropriate treatment.

Concepts: Greek loanwords, Pain, Acupuncture, Aortic dissection, Work in progress, Suffering, Vertebral artery dissection, Carotid artery dissection


Cervical artery dissection (CAD) is a common cause of stroke in young adults. There is controversy over whether anticoagulation is superior to antiplatelet therapy in preventing stroke in patients with CAD, although meta-analyses to date have not shown any difference between the two treatments.

Concepts: Biology, Myocardial infarction, Antiplatelet drug, Vertebral artery dissection, Coronary artery dissection, Carotid artery dissection


In a cohort of patients diagnosed with cervical artery dissection (CeAD), to determine the proportion of patients aged ≥60 years and compare the frequency of characteristics (presenting symptoms, risk factors, and outcome) in patients aged <60 vs ≥60 years.

Concepts: Disease, Medical terms, Greek loanwords, Symptoms, Symptom, Vertebral artery dissection, Coronary artery dissection, Carotid artery dissection


The purpose of this study was to determine the frequency of patients seen at a single institution who were diagnosed with a cervical vessel dissection related to chiropractic neck manipulation.

Concepts: Vertebral artery dissection, Chiropractic, Carotid artery dissection


Spinal manipulation has been associated with cervical arterial dissection and stroke but a causal relationship has been questioned by population-based studies. Earlier studies identified cases using International Classification of Diseases Ninth Revision (ICD-9) codes specific to anatomic stroke location rather than stroke etiology. We hypothesize that case misclassification occurred in these previous studies and an underestimation of the strength of the association. We also predicted that case misclassification would differ by patient age.

Concepts: Scientific method, Medicine, Causality, Experiment, Philosophy of science, Case, Vertebral artery dissection, Carotid artery dissection