Discover the most talked about and latest scientific content & concepts.

Concept: Cardiomegaly


-Left ventricular (LV) hypertrophy (LVH, high LV mass) is traditionally classified as concentric or eccentric based on LV relative wall thickness. We evaluated the prediction of subsequent adverse events in a new 4-group LVH classification based on LV dilatation (high LV end-diastolic volume [EDV] index) and concentricity (LVM/EDV((2/3))) in hypertensive patients.

Concepts: Geometry, Cardiomegaly, Aortic insufficiency, Hypertension, Ventricular hypertrophy, Left ventricular hypertrophy, Cardiology


Growth differentiation factor 11 and/or its homologue growth differentiation factor 8 (GDF11/8) reverses age-related cardiac hypertrophy and vascular ageing in mice. We investigated whether GDF11/8 associates with cardiovascular outcomes, left ventricular hypertrophy (LVH), or age in humans.

Concepts: Mitral valve, Cardiomegaly, Circulatory system, Blood, Ventricular hypertrophy, Heart, Left ventricular hypertrophy, Cardiology


High plasma concentration of fibroblast growth factor 23 (FGF23) is a risk factor for left ventricular hypertrophy (LVH) in adults with CKD, and induces myocardial hypertrophy in experimental CKD. We hypothesized that high FGF23 levels associate with a higher prevalence of LVH in children with CKD.

Concepts: Growth factor, Chemistry, Growth factors, Cardiomegaly, Cardiology, Fibroblast growth factor, Ventricular hypertrophy, Left ventricular hypertrophy


Frontal QRS-T angle is a novel marker of myocardial repolarization, and an increased frontal QRS-T angle associated with adverse cardiac outcomes. Non-dipper hypertension is also associated with adverse cardiac outcomes. This study aimed to investigate the relationship between frontal QRS-T angle and non-dipper status in hypertensive patients without left ventricular hypertrophy (LVH).

Concepts: Heart disease, Cardiomegaly, Myocardial infarction, Ventricular hypertrophy, Heart, Hypertension, Cardiology, Left ventricular hypertrophy


It is widely accepted that successful lowering of blood pressure (BP) in patients with hypertension leads to regression of left ventricular hypertrophy (LVH). However, whether differences exist among pharmacological BP-lowering therapies is debated. In this report, we discuss these differences in light of recent literature and the position of extant practice guidelines.

Concepts: Ventricle, Blood, Cardiomegaly, Blood pressure, Ventricular hypertrophy, Cardiology, Hypertension, Left ventricular hypertrophy


Left ventricular hypertrophy (LVH) is often encountered in clinical practice, and it is a risk factor for cardiac mortality and morbidity. Determination of the etiology and disease severity is important for the management of patients with LVH. The aim of this review is to show the remarkable progress in cardiac imaging and its importance in clinical practice.

Concepts: The Canon of Medicine, Cardiomegaly, Ventricular hypertrophy, Differential diagnosis, Epidemiology, Medical terms, Cardiology, Left ventricular hypertrophy


Data on left ventricular hypertrophy (LVH) in patients with renal artery stenosis (RAS) and its regression following renal revascularization are scanty. We performed a meta-analysis to provide comprehensive information on this clinically relevant issue.

Concepts: Kidney, Cardiomegaly, Hypertension, Ventricular hypertrophy, Renal artery, Renal artery stenosis, Cardiology, Left ventricular hypertrophy


Left ventricular hypertrophy (LVH) is very common in hemodialysis patients and an independent risk factor for mortality in this population. The myocardial remodeling underlying the LVH can affect ventricular repolarization causing abnormalities in QT interval.

Concepts: Cardiomegaly, Ventricular hypertrophy, Cardiac electrophysiology, QT interval, Left ventricular hypertrophy, Psychometrics, Cardiology


Electrocardiogram (ECG) is commonly used clinically due to convenience, but its accuracy is insufficient for left ventricular hypertrophy (LVH) diagnosis. In this study, we attempted to improve diagnostic accuracy of LVH by establishing models with ECG parameters.

Concepts: Cardiomegaly, Ventricular hypertrophy, Electrocardiography, Ventricular fibrillation, Left ventricular hypertrophy, Cardiology


Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy (LVH). However, clinical signs can be subtle and differentiation from other causes of LVH is challenging.

Concepts: Hypertrophy, Medical terms, Cardiomyopathy, Cardiomegaly, Ventricular hypertrophy, Cardiology, Left ventricular hypertrophy, Hypertrophic cardiomyopathy