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Concept: Berlin


This guideline is the result of a systematic literature review using the ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) methodology and a structured consensus conference held on 28 and 29 November 2012, in Berlin. It is a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the EU-funded network of excellence, the Global Allergy and Asthma European Network (GA(2) LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of delegates of 21 national and international societies. Urticaria is a frequent, mast cell-driven disease, presenting with wheals, angioedema, or both. The life-time prevalence for acute urticaria is approximately 20%. Chronic spontaneous urticaria and other chronic forms of urticaria do not only cause a decrease in quality of life, but also affect performance at work and school and, as such, are members of the group of severe allergic diseases. This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying its causes, eliciting factors and pathomechanisms. In addition, it outlines evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS).

Concepts: Angioedema, Berlin, Urticaria, Immune system, European Union, Medicine, Asthma, Allergy



National Cancer Control Plans (NCCPs) often describe structural requirements for high quality cancer care. During the fourth European Roundtable Meeting (ERTM) participants shared learnings from their own national setting to formulate best practice in optimizing communication strategies between parties involved in clinical cancer registries, cancer centers and guideline groups.

Concepts: Cancer, Best practice, Berlin, European Union, Germany, Quality assurance, Quality control, Management


Emmanuelle Charpentier is a French microbiologist, geneticist and biochemist. She is a Director at the Max Planck Institute for Infection Biology in Berlin, Honorary Professor at Humboldt University, Visiting Professor at Umeå University and recipient of an Alexander von Humboldt Professorship. Prior to her current appointments, she worked at several other institutions in Germany, Sweden, Austria, the US and France. Emmanuelle Charpentier’s research on a bacterial immune system laid the foundation for the ground-breaking CRISPR-Cas9 genome engineering technology. She has received numerous prestigious awards and distinctions, and is an elected member of several renowned academies of sciences. She is co-founder of CRISPR Therapeutics and ERS Genomics.

Concepts: Otto Hahn, Max Planck, Bacteria, Berlin, Max Planck Society, Humboldt University of Berlin, Alexander von Humboldt, Germany


Scientific injury data in men’s professional team handball injuries are rare and even less scientific information exists on injury prevention. In 2011, Germany’s national second team handball league was restructured by merging the existing two regional leagues into one league. This study evaluates the injury patterns in professional team handball and compares the injury rates between the first and second league before and after the restructure.

Concepts: Czech Republic, Injury, Berlin, Denmark, Team handball, Accident, Germany


 In recent decades, guideline-based therapy of myocardial infarction has led to a considerable reduction in myocardial infarction mortality. However, there are relevant differences in acute care and the extent of infarction mortality. The objective of this survey was to analyze the current care situation of patients with acute myocardial infarction in the region of northeast Germany (Berlin, Brandenburg and Mecklenburg-Vorpommern).

Concepts: Berlin, German reunification, Atherosclerosis, Brandenburg, States of Germany, Germany, East Germany, Myocardial infarction


On page 650, the institutional affiliation of Dr. Werner J.D. Ouwendijk was incorrectly listed as Freie Universitaet Berlin. It should instead be Erasmus MC, Rotterdam, The Netherlands.

Concepts: Erasmus University Rotterdam, Netherlands, European Union, Charité, Berlin, Humboldt University of Berlin, Free University of Berlin, Rotterdam


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Concepts: West Germany, Berlin, European Union, Germany


The heart of this article is the transmission of selected chapters from the Japanese bacteriologist Taichi Kitashima’s (1870-1956) autobiographical memoirs (in Japanese, Jiden) published in 1955, in which Kitashima reports on his stay in Marburg in a very personal and subjective way. Like other Japanese physicians of his generation, Kitashima spent several years in Germany in order to work with the serum researcher Emil von Behring and continued his education there. The contact came through Kitashima’s teacher Shibasaburô Kitasato, who had worked with Behring in Berlin on questions of immunology. The memoir gives insight into Behring’s laboratory work and his relation to his “subordinates”. The editors investigate to what extent Kitashima’s assessment, made from a distance of fifty years, of his stay in Germany as “wasted time” was accurate, given the advantages that arose from having been part of a vibrant European scientific community, including encounters in the Pasteur Institute in Paris, and why he cultivated his contacts with Germany and the Behring family during National Socialism.

Concepts: Virus, Berlin, Germany, Diary, Memoir, Louis Pasteur, Autobiography, Emil Adolf von Behring


Stanford acute type A aortic dissection (ATAAD) is a potentially lethal condition. Epidemiology studies show a statistical incidence in Europe of approximately 2-16 cases/100,000 inhabitants/year. In Germany, the estimated incidence (here subsumed under “thoracic aortic dissection” with 4.63 cases/100,000 inhabitants/year) is mainly extracted from medical death certificates by the German Federal Statistical Office. The prehospital incidence of ATAAD deaths is largely unknown. Since patients often die in the pre-hospital setting, the incidence of ATAAD is therefore likely to be higher than current estimates.

Concepts: Brandenburg, European Union, East Germany, Emergency medical services, Berlin, Epidemiology, Germany, Aortic dissection