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Concept: American football


Improving hydration is a strategy commonly used by clinicians to prevent overeating with the goal of promoting a healthy weight among patients. The relationship between weight status and hydration, however, is unclear. Our objective was to assess the relationship between inadequate hydration and BMI and inadequate hydration and obesity among adults in the United States.

Concepts: United States, United Kingdom, Poverty in the United States, U.S. state, American football, Ice hockey, Promoting adversaries


CCL11, a protein previously associated with age-associated cognitive decline, is observed to be increased in the brain and cerebrospinal fluid (CSF) in chronic traumatic encephalopathy (CTE) compared to Alzheimer’s disease (AD). Using a cohort of 23 deceased American football players with neuropathologically verified CTE, 50 subjects with neuropathologically diagnosed AD, and 18 non-athlete controls, CCL11 was measured with ELISA in the dorsolateral frontal cortex (DLFC) and CSF. CCL11 levels were significantly increased in the DLFC in subjects with CTE (fold change = 1.234, p < 0.050) compared to non-athlete controls and AD subjects with out a history of head trauma. This increase was also seen to correlate with years of exposure to American football (β = 0.426, p = 0.048) independent of age (β = -0.046, p = 0.824). Preliminary analyses of a subset of subjects with available post-mortem CSF showed a trend for increased CCL11 among individuals with CTE (p = 0.069) mirroring the increase in the DLFC. Furthermore, an association between CSF CCL11 levels and the number of years exposed to football (β = 0.685, p = 0.040) was observed independent of age (β = -0.103, p = 0.716). Finally, a receiver operating characteristic (ROC) curve analysis demonstrated CSF CCL11 accurately distinguished CTE subjects from non-athlete controls and AD subjects (AUC = 0.839, 95% CI 0.62-1.058, p = 0.028). Overall, the current findings provide preliminary evidence that CCL11 may be a novel target for future CTE biomarker studies.

Concepts: Brain, Death, Cognition, Neurology, Dementia, Cerebrospinal fluid, Receiver operating characteristic, American football


Visit nearly any official website for a brand-name drug available in the United States and, mixed in with links to prescribing and safety information, you’ll find links to drug “coupons,” including copayment-assistance programs and monthly savings cards. Most offers are variations on “Why pay more? With the [drug] savings card, you can get [drug] for only $18 per prescription if eligible” or “Get a free 30-capsule trial of [drug] with your doctor’s prescription and ask your doctor if [drug] is right for you.” Why do manufacturers offer drug coupons? Are they good for patients in the long run? Are they . . .

Concepts: United States, United States Constitution, U.S. state, Medical prescription, American football


Home fires account for 85% of fire deaths in the United States, the majority in 1- or 2-family homes lacking fire sprinklers. Since 1978, however, a grassroots movement has successfully promoted more than 360 local ordinances mandating sprinklers in all new residential construction, including 1- and 2-family homes. The homebuilding industry has responded by seeking state preemption of local authority, a strategy previously used by other industries concerned about protecting their profits. From 2009 through 2011, 13 states adopted laws eliminating or limiting local authority over residential fire sprinklers. This study of the residential sprinkler movement adds to our understanding of grassroots public health movements and provides additional evidence that preemption can have a negative impact on public health and safety. (Am J Public Health. Published online ahead of print August 15, 2013: e1-e8. doi:10.2105/AJPH.2013.301317).

Concepts: United States, U.S. state, Occupational safety and health, Massachusetts, American football, Construction, Local government, Fire sprinkler


The goal of this research was to identify the fraction of deaths attributable to diabetes in the United States.

Concepts: United States, Poverty in the United States, U.S. state, American football, Humid subtropical climate, Ice hockey


Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject’s death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (rs = 0.59, P = .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular-rotational acceleration-deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients.

Concepts: Psychology, Brain, Spearman's rank correlation coefficient, Cognition, Cerebral cortex, Mesencephalon, Autopsy, American football



Recurrent hamstring injuries are a major problem in sports such as football. The aim of this paper was to use a clinical example to describe a treatment strategy for the management of recurrent hamstring injuries and examine the evidence for each intervention. A professional footballer sustained five hamstring injuries in a relatively short period of time. The injury was managed successfully with a seven-point programme-biomechanical assessment and correction, neurodynamics, core stability, eccentric strengthening, an overload running programme, injection therapies and stretching/relaxation. The evidence for each of these treatment options is reviewed. It is impossible to be definite about which aspects of the programme contributed to a successful outcome. Only limited evidence is available in most cases; therefore, decisions regarding the use of different treatment modalities must be made by using a combination of clinical experience and research evidence.

Concepts: Time, Game theory, Association football, American football, Chess, Football, Professional sports, Columbus, Ohio


The purpose of this study was to investigate the relationship between physical workload and injury risk in elite youth football players.

Concepts: American football


How much does a fumble affect the probability of winning an American football game? How balanced should your offense be in order to increase the probability of winning by 10%? These are questions for which the coaching staff of National Football League teams have a clear qualitative answer. Turnovers are costly; turn the ball over several times and you will certainly lose. Nevertheless, what does “several” mean? How “certain” is certainly? In this study, we collected play-by-play data from the past 7 NFL seasons, i.e., 2009-2015, and we build a descriptive model for the probability of winning a game. Despite the fact that our model incorporates simple box score statistics, such as total offensive yards, number of turnovers etc., its overall cross-validation accuracy is 84%. Furthermore, we combine this descriptive model with a statistical bootstrap module to build FPM (short for Football Prediction Matchup) for predicting future match-ups. The contribution of FPM is pertinent to its simplicity and transparency, which however does not sacrifice the system’s performance. In particular, our evaluations indicate that our prediction engine performs on par with the current state-of-the-art systems (e.g., ESPN’s FPI and Microsoft’s Cortana). The latter are typically proprietary but based on their components described publicly they are significantly more complicated than FPM. Moreover, their proprietary nature does not allow for a head-to-head comparison in terms of the core elements of the systems but it should be evident that the features incorporated in FPM are able to capture a large percentage of the observed variance in NFL games.

Concepts: Statistics, College football, American football, National Football League, American Football League, Super Bowl, Oakland Raiders, NFL on CBS