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Concept: Acute uric acid nephropathy

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Dual-urate lowering therapy (ULT) with xanthine oxidase inhibitor and uricosuric medications is a treatment option for severe gout. Uricosurics can cause hyperuricosuria, a risk factor for nephrolithiasis and acute uric acid nephropathy. The aims of this study were to simulate the relation between suboptimal drug adherence and efficacy, and to quantify the risk of hyperuricosuria in gout patients receiving mono and dual-ULTs.

Concepts: Gout, Uric acid, Hyperuricemia, Xanthine oxidase, Xanthine, Hyperuricosuria, Uricosuric, Acute uric acid nephropathy