Discover the most talked about and latest scientific content & concepts.

Concept: Acute accent


Aggressive diuretic therapy in a patient who is hospitalized for acute decompensated heart failure often leads to progressive renal dysfunction despite persistent congestion. The underlying mechanisms of this so-called acute cardiorenal syndrome are complex and not fully understood.(1),(2) As initial therapy in this setting, ultrafiltration as compared with diuretic therapy may result in a higher rate of sodium and volume removal, with greater weight loss and less frequent rehospitalizations.(3),(4) These findings have suggested that ultrafiltration can provide more effective relief of congestion than pharmacologic therapy can, particularly in the setting of cardiorenal compromise. Ultrafiltration may also reduce diuretic-induced . . .

Concepts: Medicine, Hospital, Heart failure, Diuretic, Acute accent, Acute decompensated heart failure


To determine the efficacy of high-dose antioxidants in the acute stage of central serous chorioretinopathy (CSC).

Concepts: Randomized controlled trial, Acute accent, Central serous retinopathy


The objective of the study is a comparative evaluation of flavone isolated from Mucuna pruriens and coumarin isolated from Ionidium suffruticosum was assessed for the hypolipidemic activity in rats fed with high fat diet. The acute toxicity study was found that flavone (M.pruriens) and coumarin (I.suffruticosum) are safe up to 100mg/kg, so one tenth of this dose (10mg/kg) was consider as a evaluation dose. High fat diet group of rats showed significant (p<0.001) elevation in plasma total and LDL-cholesterol, triglycerides and phospholipids. Administration of flavone (M. pruriens) and coumarin isolated from (I.suffruticosum) at the dose of 10mg/kg b.wt/day along with high fat diet significantly (p<0.001) prevented the rise in the plasma total and LDL-cholesterol, triglycerides and phospholipids than that of other extracts. However, treatment of coumarin isolated from (I.suffruticosum) had showed more cardio protective effect against hyperlipidemia than that of flavone (M.pruriens).

Concepts: Cholesterol, Fatty acid, Statin, Toxicology, Acute accent, Glycerol, Acute toxicity, Mucuna pruriens


Cannabis is commonly used to alleviate symptoms of negative affect. However, a paucity of research has examined the acute effects of cannabis on negative affect in everyday life. The current study provides a naturalistic account of perceived changes in symptoms of depression, anxiety, and stress as a function of dose and concentration of Δ9tetrahydrocannabinol (THC) and cannabidiol (CBD).

Concepts: Psychology, Cannabinoid receptor, Acute accent


Social cognition influences social interactions. Alcohol reportedly facilitates social interactions. However, the acute effects of alcohol on social cognition are relatively poorly studied.

Concepts: Psychology, Sociology, Cultural studies, Emotion, Acute accent, Emotions and culture, Social neuroscience


To determine whether multiparametric MRI data can provide insight into the acute and long-lasting neuronal sequelae after a concussion in adolescent athletes.

Concepts: Medical terms, Axon, Acute accent, Concussion


More than a decade of research has supported a robust consensus: Acute stress impairs memory retrieval. We aimed to determine whether a highly effective learning technique could strengthen memory against the negative effects of stress. To bolster memory, we used retrieval practice, or the act of taking practice tests. Participants first learned stimuli by either restudying or engaging in retrieval practice. Twenty-four hours later, we induced stress in half of the participants and assessed subsequent memory performance. Participants who learned by restudying demonstrated the typical stress-related memory impairment, whereas those who learned by retrieval practice were immune to the deleterious effects of stress. These results suggest that the effects of stress on memory retrieval may be contingent on the strength of the memory representations themselves.

Concepts: Psychology, Learning, Acute accent


The infectivity of the HIV-1 acute phase has been directly measured only once, from a retrospectively identified cohort of serodiscordant heterosexual couples in Rakai, Uganda. Analyses of this cohort underlie the widespread view that the acute phase is highly infectious, even more so than would be predicted from its elevated viral load, and that transmission occurring shortly after infection may therefore compromise interventions that rely on diagnosis and treatment, such as antiretroviral treatment as prevention (TasP). Here, we re-estimate the duration and relative infectivity of the acute phase, while accounting for several possible sources of bias in published estimates, including the retrospective cohort exclusion criteria and unmeasured heterogeneity in risk.

Concepts: Antiretroviral drug, HIV, AIDS, HIV/AIDS, Viral load, Scientific method, Cohort study, Acute accent


Optimal management of rectal prolapse requires multiple clinical considerations with respect to treatment options, particularly for surgeons who must counsel and give realistic expectations to rectal prolapse patients. Rectal prolapse outcomes are good with respect to recurrence. Although posterior rectopexy remains most popular in the United States, increasingly surgeons perform ventral rectopexy to repair rectal prolapse. Functional outcomes vary and are fair after rectal prolapse repair. Although incarceration with rectal prolapse is rare, it is potentially life threatening and requires immediate and effective measures to adequately address in the acute setting.

Concepts: United States, Surgery, Poverty in the United States, U.S. state, Spanish language, Acute accent, Rectal prolapse


Abstract This study investigated the acute effects of different sizes of paddles on the force-time curve during tethered swimming and swimming velocity in front-crawl stroke. Fourteen male swimmers (20.0 ± 3.7 years; 100-m best time: 53.70 ± 0.87 s) performed two 10-s maximal efforts in tethered swimming to obtain peak force, average force, impulse, rate of force development, stroke duration and time to peak force. Swimming velocity, stroke rate and stroke length were obtained from two 25-m maximal swims. Both tests were repeated in five conditions: free swimming, wearing small (280 cm (2) ), medium (352 cm (2) ), large (462 cm (2) ) and extra-large (552 cm (2) ) hand paddles. Compared to free swimming, paddles provided significant increases of peak force (medium: 11.5%, large: 16.7%, extra-large: 21.7%), impulse (medium: 15.2%, large: 22.4%, extra-large: 30.9%), average force (medium: 5.1%, large: 7.5%), rate of force development (extra-large: 11.3%), stroke duration (medium: 9.3%, large: 11.8%, extra-large: 18.5%), time to peak force (medium: 11.1%, large: 15.9%, extra-large: 22.1%), swimming velocity (medium: 2.2%, large: 3.2%, extra-large: 3.7%) and stroke length (medium: 9.0%, large: 9.0%, extra-large: 14.8%), while stroke rate decreased (medium: -6.2%, large: -5.5%, extra-large: -9.5%). It is concluded that medium, large and extra-large paddles influence the force-time curve and change swimming velocity, suggesting these sizes may be useful for force development in water.

Concepts: Time, Acute accent, Swimming, Human swimming