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Concept: Actuarial science


To examine the associations between the regular consumption of spicy foods and total and cause specific mortality.

Concepts: Cohort study, Longitudinal study, Cohort, Epidemiology, Demography, Actuarial science, Spice


Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews missed several studies and additional studies have since been published. We therefore conducted a systematic review and meta-analysis of nut consumption and risk of cardiovascular disease, total cancer, and all-cause and cause-specific mortality.

Concepts: Medicine, Epidemiology, Disease, Infectious disease, Death, Senescence, Demography, Actuarial science


 To examine the role of psychological distress (anxiety and depression) as a potential predictor of site specific cancer mortality.

Concepts: Anxiety, Psychology, Cohort study, Cohort, Epidemiology, Actuarial science


 To evaluate associations between different definitions of prediabetes and the risk of cardiovascular disease and all cause mortality.

Concepts: Medicine, Epidemiology, Actuarial science


 To conduct a systematic review and meta-analysis of cohort studies of body mass index (BMI) and the risk of all cause mortality, and to clarify the shape and the nadir of the dose-response curve, and the influence on the results of confounding from smoking, weight loss associated with disease, and preclinical disease.

Concepts: Medicine, Epidemiology, Death, Demography, Obesity, Actuarial science, Mass, Body mass index


 To evaluate the association between migraine and incident cardiovascular disease and cardiovascular mortality in women.

Concepts: Epidemiology, Actuarial science


Rock and pop fame is associated with risk taking, substance use and premature mortality. We examine relationships between fame and premature mortality and test how such relationships vary with type of performer (eg, solo or band member) and nationality and whether cause of death is linked with prefame (adverse childhood) experiences.

Concepts: Cohort study, Longitudinal study, Death, Demography, Actuarial science, Rock music, David Bowie, Fame


OBJECTIVE: Low-carbohydrate diets and their combination with high-protein diets have been gaining widespread popularity to control weight. In addition to weight loss, they may have favorable short-term effects on the risk factors of cardiovascular disease (CVD). Our objective was to elucidate their long-term effects on mortality and CVD incidence. DATA SOURCES: MEDLINE, EMBASE, ISI Web of Science, Cochrane Library, and for relevant articles published as of September 2012. Cohort studies of at least one year’s follow-up period were included. REVIEW METHODS: Identified articles were systematically reviewed and those with pertinent data were selected for meta-analysis. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) for all-cause mortality, CVD mortality and CVD incidence were calculated using the random-effects model with inverse-variance weighting. RESULTS: We included 17 studies for a systematic review, followed by a meta-analysis using pertinent data. Of the 272,216 people in 4 cohort studies using the low-carbohydrate score, 15,981 (5.9%) cases of death from all-cause were reported. The risk of all-cause mortality among those with high low-carbohydrate score was significantly elevated: the pooled RR (95% CI) was 1.31 (1.07-1.59). A total of 3,214 (1.3%) cases of CVD death among 249,272 subjects in 3 cohort studies and 5,081 (2.3%) incident CVD cases among 220,691 people in different 4 cohort studies were reported. The risks of CVD mortality and incidence were not statistically increased: the pooled RRs (95% CIs) were 1.10 (0.98-1.24) and 0.98 (0.78-1.24), respectively. Analyses using low-carbohydrate/high-protein score yielded similar results. CONCLUSION: Low-carbohydrate diets were associated with a significantly higher risk of all-cause mortality and they were not significantly associated with a risk of CVD mortality and incidence. However, this analysis is based on limited observational studies and large-scale trials on the complex interactions between low-carbohydrate diets and long-term outcomes are needed.

Concepts: Scientific method, Epidemiology, Clinical trial, Medical statistics, Risk, Evidence-based medicine, Actuarial science, Relative risk


 To determine whether atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men.

Concepts: Medicine, Epidemiology, Disease, Heart, Atrial fibrillation, Actuarial science


Leisure time physical activity reduces the risk of premature mortality, but the years of life expectancy gained at different levels remains unclear. Our objective was to determine the years of life gained after age 40 associated with various levels of physical activity, both overall and according to body mass index (BMI) groups, in a large pooled analysis.

Concepts: Death, Demography, Obesity, Actuarial science, Mass, Body mass index, Life expectancy, Personal life