SciCombinator

Discover the most talked about and latest scientific content & concepts.

Concept: According to Jim

168

Studies on bimatoprost were performed with two objectives: (i) to determine whether bimatoprost possesses hair growth-stimulating properties beyond eyelash hypertrichosis and (ii) to investigate the biodisposition of bimatoprost in skin for the first time. Bimatoprost, at the dose used clinically for eyelash growth (0.03%) and given once daily for 14 days, increased pelage hair growth in C57/black 6 mice. This occurred as a much earlier onset of new hair growth in shaved mice and the time taken to achieve complete hair regrowth, according to photographic documentation and visual assessment. Bimatoprost biodisposition in the skin was determined at three concentrations: 0.01%, 0.03% and 0.06%. Dose-dependent C(max) values were obtained (3.41, 6.74, 12.3 μg/g tissue), and cutaneous bimatoprost was well maintained for 24 h following a single dose. Bimatoprost was recovered from the skin only as the intact molecule, with no detectable levels of metabolites. Thus, bimatoprost produces hypertrichosis as the intact molecule.

Concepts: Skin, Tissue, According to Jim, Mouse, Hair follicle, Keratin, Facial hair, Hair removal

164

The clinical features of various facial deformities in Korean leprosy patients were evaluated according to the type of leprosy.

Concepts: According to Jim, Leprosy

141

The pathophysiology underlying very late drug-eluting stent (DES) thrombosis is not sufficiently understood. Using optical coherence tomography, we investigated characteristics of very late stent thrombosis (VLST) according to different onset times.

Concepts: Optics, Tomographic reconstruction, Stent, Tomography, According to Jim

140

To examine whether respondents to a survey of health and physical activity and potential determinants could be grouped according to the questions they missed, known as ‘item missing’.

Concepts: Scientific method, Observational study, Knowledge, According to Jim

136

Pubertal growth pattern differs according to age at pubertal growth spurt onset which occurs over a five years period (girls: 8-13 years, boys: 10-15 years). The need for more than one pubertal reference pattern has been proposed. We aimed to obtain five 1-year-age-interval pubertal patterns.

Concepts: Hypothalamus, Child, Childhood, Menstrual cycle, According to Jim, Pattern, Puberty, Menarche

48

To study how reproductive risks and perinatal outcomes are associated with postpartum depression treated in specialised healthcare defined according to the International Classification of Diseases (ICD)-10 codes, separately among women with and without a history of depression.

Concepts: Pregnancy, Childbirth, Obstetrics, According to Jim, Postpartum depression

46

Humans often evaluate sensory signals according to their reliability for optimal decision-making. However, how do we evaluate percepts generated in the absence of direct input that are, therefore, completely unreliable? Here, we utilize the phenomenon of filling-in occurring at the physiological blind-spots to compare partially inferred and veridical percepts. Subjects chose between stimuli that elicit filling-in, and perceptually equivalent ones presented outside the blind-spots, looking for a Gabor stimulus without a small orthogonal inset. In ambiguous conditions, when the stimuli were physically identical and the inset was absent in both, subjects behaved opposite to optimal, preferring the blind-spot stimulus as the better example of a collinear stimulus, even though no relevant veridical information was available. Thus, a percept that is partially inferred is paradoxically considered more reliable than a percept based on external input. In other words: Humans treat filled-in inferred percepts as more real than veridical ones.

Concepts: 2002 albums, Perception, Reliability, According to Jim, In the Absence of Truth, Absenteeism

33

The rate of contralateral prophylactic mastectomies (CPMs) continues to rise, although there is little evidence to support improvement in quality of life (QOL) with CPM. We sought to ascertain whether patient-reported outcomes and, more specifically, QOL differed according to receipt of CPM.

Concepts: Life, Quality, Quality of life, According to Jim, Quality-of-life index, Mastectomy, CPM

32

Progressive multifocal leukoencephalopathy (PML) is associated with natalizumab treatment. We quantified the risk of PML in patients with multiple sclerosis, according to the presence or absence of three risk factors: positive status with respect to anti-JC virus antibodies, prior use of immunosuppressants, and increasing duration of natalizumab treatment.

Concepts: Multiple sclerosis, According to Jim, Progressive multifocal leukoencephalopathy, Progressive lens, Natalizumab, Treatment of multiple sclerosis

31

Autologous bone marrow stem cell therapy is the greatest advance in the treatment of heart disease for a generation according to pioneering reports. In response to an unanswered letter regarding one of the largest and most promising trials, we attempted to summarise the findings from the most innovative and prolific laboratory.

Concepts: Bone, Stem cell, Bone marrow, Heart, Heart disease, Organ, According to Jim