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V Ivanov, D Coso, B Chetaille, B Esterni, D Olive, T Aurran-Schleinitz, JM Schiano, AM Stoppa, F Broussais-Guillaumot, D Blaise and R Bouabdallah
Abstract
ABSTRACT Initial clinical trials demonstrated that lenalidomide monotherapy has a significant activity against some subtypes of lymphoma, but in diffuse large B-cell lymphoma (DLBCL) its activity is limited. Combination of lenalidomide with rituximab may be a promising therapeutic strategy. We retrospectively analyzed clinical outcomes in 17 relapsed/refractory (R/R) DLBCL patients, treated with lenalidomide, 25 mg/d for 21/28 days and rituximab, 375 mg/m(2) on day 7 of every lenalidomide cycle, for a maximum of 12 months. The ORR was 41.2% with 35.3% CR, while median response duration was 26.5 months at a median follow-up of 24.9 months. Two CR patients relapsed after 4 and 27 months of CR, and other 4 are actually in CR at +13,+23+24 and +29 months. The estimated 24-months OS was 45% and PFS was 38%. Adverse events were manageable and mostly included thrombocytopenia and neutropenia. Lenalidomide-rituximab is active in R/R DLBCL with important percentage of continuous CR.
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Concepts
T-cell lymphoma, Rituximab, B cell, Clinical trial, B-cell lymphoma, Types of cancer, Diffuse large B cell lymphoma, Lymphoma
MeSH headings
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