SciCombinator

Discover the most talked about and latest scientific content & concepts.

A Forte, M Cipollaro and U Galderisi
Abstract
Human endometrium is a highly dynamic tissue, undergoing periodic growth and regression at each menstrual cycle. Endometriosis is a frequent chronic pathological status characterized by endometrial tissue with an ectopic localization, causing pelvic pain and infertility and a variable clinical presentation. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation in approximately 1.0% of affected women, with the involvement of multiple pathways of development. Increasing evidence supports a key contribution of different stem/progenitor cell populations not only in the cyclic regeneration of eutopic endometrium, but also in the pathogenesis of at least some types of endometriosis. Evidence has arisen from experiments in animal models of disease through different kinds of assays (including clonogenicity, the label-retaining cell approach, the analysis of undifferentiation markers), as well as from descriptive studies on ectopic and eutopic tissue samples harvested from affected women. Changes in stem cell populations in endometriotic lesions are associated with genetic and epigenetic alterations, including imbalance of miRNA expression, histone and DNA modifications and chromosomal aberrations. The present short review mainly summarizes the latest observations contributing to the current knowledge regarding the presence and the potential contribution of stem/progenitor cells in eutopic endometrium and the aetiology of endometriosis, together with a report of the most recently identified genetic and epigenetic alterations in endometriosis. We also describe the potential advantages of single cell molecular profiling in endometrium and in endometriotic lesions. All these data can have clinical implications and provide a basis for new potential therapeutic applications.
Tweets*
3
Facebook likes*
5
Reddit*
0
News coverage*
1
Blogs*
0
SC clicks
1
Concepts
Cell, Chromosome, Gene, Histone, Endometriosis, DNA, Menstrual cycle, Endometrium
MeSH headings
Animals, DNA, Down-Regulation, Endometriosis, Endometrium, Epigenesis, Genetic, Female, Histones, Humans, Menstruation, MicroRNAs, Ovarian Neoplasms, RNA, Messenger, Stem Cells, Up-Regulation
comments powered by Disqus

* Data courtesy of Altmetric.com