Upregulation of Trefoil Factor 3 (TFF3) After Rectal Cancer Chemoradiotherapy Is an Adverse Prognostic Factor and a Potential Therapeutic Target.
International journal of radiation oncology, biology, physics | 21 Apr 2012
E Casado, VM Garcia, JJ Sánchez, MT Gómez Del Pulgar, J Feliu, J Maurel, B Castelo, J Moreno Rubio, RA López, MÁ García-Cabezas, E Burgos, J de Castro, C Belda-Iniesta, M López-Gómez, C Gómez-Raposo, F Zambrana, M Sereno, C Fernández-Martos, P Vázquez, JC Lacal, M González-Barón and P Cejas
Management of locally advanced rectal cancer (RC) consists of neoadjuvant chemoradiotherapy (CRT) with fluoropyrimidines, followed by total mesorectal excision. We sought to evaluate the expression of selected genes, some of which were derived from a previous undirected SAGE (serial analysis of gene expression)-based approach, before and after CRT, to identify mechanisms of resistance.
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