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E Casado, VM Garcia, JJ Sánchez, MT Gómez Del Pulgar, J Feliu, J Maurel, B Castelo, J Moreno Rubio, RA López, MÁ García-Cabezas, E Burgos, J de Castro, C Belda-Iniesta, M López-Gómez, C Gómez-Raposo, F Zambrana, M Sereno, C Fernández-Martos, P Vázquez, JC Lacal, M González-Barón and P Cejas
Abstract
Management of locally advanced rectal cancer (RC) consists of neoadjuvant chemoradiotherapy (CRT) with fluoropyrimidines, followed by total mesorectal excision. We sought to evaluate the expression of selected genes, some of which were derived from a previous undirected SAGE (serial analysis of gene expression)-based approach, before and after CRT, to identify mechanisms of resistance.
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Concepts
Transcription, Cancer, Serial analysis of gene expression, Total mesorectal excision, Colorectal cancer, Molecular biology, Gene, Gene expression
MeSH headings
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